How a Disrupted Clock may Cause a Decline in Learning and Memory

Colwell, Christopher S.

doi:10.1002/9781118467831.ch16

Cited by 1 publication

(1 citation statement)

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“…Although LA and body temperature were synchronized with each other, other internal rhythms might be desynchronized, suggesting a masking effect of light on LA and correlated body temperature, as previously mentioned. A lot of studies report the negative effect of body rhythms desynchrony on neuro-behavioural functions, especially during ageing, when the biological clock undergoes severe alterations [48,55]. In that case, weaker learning performances in T26 animals would rather be due to a potential internal desynchrony rather than to a cost of synchronization.…”

Section: Discussionmentioning

confidence: 99%

Physiological and cognitive consequences of a daily 26 h photoperiod in a primate:exploring the underlying mechanisms of the circadian resonance theory

Hozer

Pifferi

2020

Proc. R. Soc. B.

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The biological clock expresses circadian rhythms, whose endogenous period (tau) is close to 24 h. Daily resetting of the circadian clock to the 24 h natural photoperiod might induce marginal costs that would accumulate over time and forward affect fitness. It was proposed as the circadian resonance theory. For the first time, we aimed to evaluate these physiological and cognitive costs that would partially explain the mechanisms of the circadian resonance hypothesis. We evaluated the potential costs of imposing a 26 h photoperiodic regimen compared to the classical 24 h entrainment measuring several physiological and cognitive parameters (body temperature, energetic expenditure, oxidative stress, cognitive performances) in males of a non-human primate ( Microcebus murinus ), a nocturnal species whose endogenous period is about 23.5 h. We found significant higher resting body temperature and energy expenditure and lower cognitive performances when the photoperiodic cycle length was 26 h. Together these results suggest that a great deviation of external cycles from tau leads to daily greater energetic expenditure, and lower cognitive capacities. To our knowledge, this study is the first to highlight potential mechanisms of circadian resonance theory.

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Section: Discussionmentioning

confidence: 99%