"Hot cross bun" sign in HIV-related progressive multifocal leukoencephalopathy

Yadav, Ravi; Ramdas, Mahendra; Karthik, Naveen; Kulkarni, Girish Baburao; Rose, Dawn; Kumar, M Veerendra; Nagaraja, D

doi:10.4103/0028-3886.79149

Cited by 18 publications

(22 citation statements)

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“…Moreover, our patient had predominant involvement of posterior fossa structures similar to the findings reported by others. [3,4] No specific treatment is available for PML in HIV patients currently; however, early administration of highly active anti-retroviral therapy (HAART) is recommended to prevent this dreaded complication. …”

Section: Department Of Neurology Sawai Man Singh Medical College Jamentioning

confidence: 99%

′Hot-cross bun′ and ′inverse trident sign′ in progressive multifocal leukoencephalopathy with HIV seropositivity

2014

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Section: Department Of Neurology Sawai Man Singh Medical College Jamentioning

confidence: 99%

′Hot-cross bun′ and ′inverse trident sign′ in progressive multifocal leukoencephalopathy with HIV seropositivity

2014

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“…HCB sign has also been described in spinocerebellar ataxia types 2 and 3,9 in a variant of Creutzfeldt-Jakob disease10 and in a case of severe Parkinsonian syndrome associated with cerebellar and brainstem dysfunction owing to presumed vasculitis 11. Yadav et al 12 reported HIV-related progressive multifocal leucoencephalopathy as a rare cause of HCB sign in two of their patients. To the best of our knowledge HCB sign in CTX has not been reported so far in the literature as seen in our patient.…”

Section: Discussionmentioning

confidence: 96%

‘Hot cross bun’ sign in a case of cerebrotendinous xanthomatosis: a rare neuroimaging observation

et al. 2013

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We report a 25-year-old young man presenting with cognitive decline, pancerebellar features, spastic quadriparesis, bilateral cataract (operated) and tendo-Achilles swelling (xanthoma). The CT of the head showed bilateral cerebellar hypodensities. There were bilateral cerebellar hypointensities involving dentate nuclei on T1-weighted images with corresponding hyperintensities on T2-weighted MRI. Additionally, an interesting MRI finding-'hot cross bun' appearance was seen in pons which has not been reported in the literature so far. Biopsy from tendo-Achilles confirmed xanthoma. He was treated with chenodeoxycholic acid following which he showed improvement in cognition and weakness.

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“…[34] Muqit et al .,[5] in 2001 described a patient with parkinsonism due to presumed vasculitis with HCB sign on MRI. HCB sign has been reported in two patients with HIV-related PML from India by Yadav et al .,[6] [Table 1]. The HCB appearance in PML is probably due to the damage and subsequent gliosis of the cerebellar connections and pontocerebellar fibers in the pons due to viral infection [Table 2] (Lists imaging differentiating features of PML from MSA and SCA).…”

Section: Discussionmentioning

confidence: 99%