Host Prdx6 contributing to the intracellular survival of Brucella suis S2 strain

Wang, Lulu; Chen, Xiaofeng; Hu, Pan; Lu, Shiying; Fu, Bao‐Quan; Li, Yansong; Zhai, Fei-Fei; Ju, Dan-Di; Zhang, Shijun; Shui, Yi-Ming; Chang, Jiang; Ma, Xiaolong; Su, Bing; Zhou, Yu; Liu, Zengshan; Ren, Hong-Lin

doi:10.1186/s12917-019-2049-8

Cited by 7 publications

(5 citation statements)

References 27 publications

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“…The role played by the host protein peroxiredoxin 6 (Prdx6) in Brucella S2 vaccine strain persistence has been investigated in a RAW264.7 murine macrophage model, showing a correlation between the intracellular concentration of the protein and the bacterium; the higher it gets, the more the intracellular survival of the B. suis S2 strain and contrarily its depletion leads to reduction in the B. suis S2 strain load, respectively [84].…”

Section: Survival Replication and The Induced Molecular Response In V...mentioning

confidence: 99%

The advances of the Chinese Brucella suis strain 2 vaccine

Jiang

Feng

et al. 2023

Animal Research and One Health

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Brucellosis, a worldwide crucial zoonotic disease, poses global socioeconomic risks to the system by threatening human health and animal reproduction. In recent years, with the increase of animal husbandry, animal brucellosis has become a remarkable health issue in China. To prevent and control the spread of brucellosis, Brucella suis live strain S2 vaccine has been licensed as a multivalent vaccine against the three major zoonotic Brucella species, for example, Brucella melitensis (small ruminants), Brucella abortus (bovids), and B. suis (swine). Following this process, the country enforced control measures based upon B. suis S2 vaccination, which reduced the disease burden in 2022 to 0.66% in the livestock population. The aim of this paper is to review and discuss the biological properties of the S2 vaccine and its wide use in vaccination programs of China, highlighting oral vaccination advantages, validation, and standardization of this vaccine as well as the progress of the S2 vaccination program achieved in the national control of the three zoonotic Brucella species.

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Section: Survival Replication and The Induced Molecular Response In V...mentioning

confidence: 99%

The advances of the Chinese Brucella suis strain 2 vaccine

Jiang

Feng

et al. 2023

Animal Research and One Health

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“…Brucella flagellin is also crucial for immune evasion and lacks the distinctive characteristic identified by toll-like receptor-5 (TLR5) ( 114 ). In addition, host peroxiredoxin 6 (Prdx6), a bifunctional protein with peroxidase and phospholipase activities, has a function in Brucella infection by increasing the intracellular survival of the B. suis S2 strain ( 115 ).…”

Section: Immunitymentioning

confidence: 99%

Brucellae as resilient intracellular pathogens: epidemiology, host–pathogen interaction, recent genomics and proteomics approaches, and future perspectives

Dawood,

Elrashedy,

Nayel

et al. 2023

Front. Vet. Sci.

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Brucellosis is considered one of the most hazardous zoonotic diseases all over the world. It causes formidable economic losses in developed and developing countries. Despite the significant attempts to get rid of Brucella pathogens in many parts of the world, the disease continues to spread widely. Recently, many attempts proved to be effective for the prevention and control of highly contagious bovine brucellosis, which could be followed by others to achieve a prosperous future without rampant Brucella pathogens. In this study, the updated view for worldwide Brucella distribution, possible predisposing factors for emerging Brucella pathogens, immune response and different types of Brucella vaccines, genomics and proteomics approaches incorporated recently in the field of brucellosis, and future perspectives for prevention and control of bovine brucellosis have been discussed comprehensively. So, the current study will be used as a guide for researchers in planning their future work, which will pave the way for a new world without these highly contagious pathogens that have been infecting and threatening the health of humans and terrestrial animals.

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“…CLEC12A [352], KLRG1 [353], NLRP12 [354], PECAM1 [355], ICAM3 [356], PIM1 [357], EEF1A1 [358], MPEG1 [359], CCR4 [360], CX3CR1 [361], EOMES (eomesodermin) [362], LYZ (lysozyme) [363], CD244 [364], GNLY (granulysin) [365], ZAP70 [366], FOXO3 [367], CD28 [368], GPX1 [369], TLR1 [370], PRDX6 [371], TLR6 [370], C5AR2 [372], LRRK2 [373], CCL5 [374], ETS1 [375], SH2D1A [376], CCR3 [377], GZMA (granzyme A) [378], CD48 [379], LTB (lymphotoxin beta) [380], THEMIS (thymocyte selection associated) [381], PICALM (phosphatidylinositol binding clathrin assembly protein) [382], PTAFR (platelet activating factor receptor) [383], BSG (basigin (Ok blood group)) [384], ALOX5 [385], VIM (vimentin) [386], CD1D [387], TNFSF4 [388], CORO1A [389], TAL1 [390], ICAM2 [391], TLR4 [392], FLNA (filamin A) [393], CCR7 [394], DPP4 [395], NLRC4 [396], TLR2 [397], CSF1R [398], LGALS1 …”

Section: Mirna-hub Gene Regulatory Network Constructionmentioning

confidence: 99%

Comprehensive analysis of next-generation sequencing data in COVID-19 and its secondary complications

Vastrad¹,

Vastrad²

2022

Preprint

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The ongoing pandemic of coronavirus disease 2019 (COVID-19) has made a serious public health threat globally. To discover key molecular changes in COVID-19 and its secondary complications, we analyzed next-generation sequencing (NGS) data of COVID-19. NGS data (GSE163151) was screened and downloaded from the Gene Expression Omnibus database (GEO). Differentially expressed genes (DEGs) were identified in the present study, using DESeq2 package in R programming software. Gene ontology (GO) and pathway enrichment analysis were performed, and the protein-protein interaction (PPI) network, module analysis, miRNA-hub gene regulatory network and TF-hub gene regulatory network were established. Subsequently, receiver operating characteristic curve (ROC) analysis was used to validate the diagonostics valuesof the hub genes. Firstly, 954 DEGs (477 up regulated and 477 down regulated) were identified from the four NGS dataset. GO enrichment analysis revealed enrichment of DEGs in genes related to the immune system process and multicellular organismal process, and REACTOME pathway enrichment analysis showed enrichment of DEGs in the immune system and formation of the cornified envelope. Hub genes were identified from the PPI network, module analysis, miRNA-hub gene regulatory network and TF-hub gene regulatory network. Furthermore, the ROC analysis indicate that COVID-19 and its secondary complications with following hub genes, namely, RPL10, FYN, FLNA, EEF1A1, UBA52, BMI1, ACTN2, CRMP1, TRIM42 and PTCH1, had good diagnostics values. This study identified several genes associated with COVID-19 and its secondary complications, which improves our knowledge of the disease mechanism.

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Host Prdx6 contributing to the intracellular survival of Brucella suis S2 strain

Cited by 7 publications

References 27 publications

The advances of the Chinese Brucella suis strain 2 vaccine

The advances of the Chinese Brucella suis strain 2 vaccine

Brucellae as resilient intracellular pathogens: epidemiology, host–pathogen interaction, recent genomics and proteomics approaches, and future perspectives

Comprehensive analysis of next-generation sequencing data in COVID-19 and its secondary complications

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