Host miRNAs are involved in hormonal regulation of HaSNPV‐triggered climbing behaviour in <i>Helicoverpa armigera</i>

Zhang, Songdou; An, Shiheng; Hoover, Kelli; Li, Zhen; Li, Xiangrui; Liu, X.; Shen, Zhizhang; Fang, Haibo; Ros, V.I.D.; Zhang, Qingwen

doi:10.1111/mec.14457

Cited by 36 publications

(32 citation statements)

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“…In H. armigera , 20E and JH are involved in the control of climbing behaviors of single nucleopolyhedrovirus ( HaSNPV ) infected larvae. Methoprene treatment decreases expression of Br-C Z2 and increases expression of these miRNAs miR-8 and miR-429 which could target Br-C Z2 ( Zhang S. et al, 2018 ), implying the miRNA-mediated crosstalk between 20E and JH.…”

Section: Microrna Regulations On Sesquiterpenoidsmentioning

confidence: 99%

Diversity of Insect Sesquiterpenoid Regulation

Tsang

Law

et al. 2020

Front. Genet.

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Insects are arguably the most successful group of animals in the world in terms of both species numbers and diverse habitats. The sesquiterpenoids juvenile hormone, methyl farnesoate, and farnesoic acid are well known to regulate metamorphosis, reproduction, sexual dimorphism, eusociality, and defense in insects. Nevertheless, different insects have evolved with different sesquiterpenoid biosynthetic pathway as well as products. On the other hand, non-coding RNAs such as microRNAs have been implicated in regulation of many important biological processes, and have recently been explored in the regulation of sesquiterpenoid production. In this review, we summarize the latest findings on the diversity of sesquiterpenoids reported in different groups of insects, as well as the recent advancements in the understanding of regulation of sesquiterpenoid production by microRNAs.

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Section: Microrna Regulations On Sesquiterpenoidsmentioning

confidence: 99%

Diversity of Insect Sesquiterpenoid Regulation

Tsang

Law

et al. 2020

Front. Genet.

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“…Furthermore, involvement of Pigment-dispersing factors (PDFs) widely distributed and coexisted with per in insect optic lobes and brain are found to be actively involved in regulating the locomotor activity in drosophila and cricket, Teleogryllus commodus 34 , 35 as well as in various complex behavioral and physiological traits in insect including geotaxis 36 , circadian phase shifting 37 , 38 and in regulation of ecdysone biosynthesis via G-protein couple receptors and also through extracellular Ca 2+ mediated pathways 39 , 40 . In this context, significant differential regulation of per gene, alteration of circadian rhythm, significant upregulation of extracellular Ca 2+ and guanine nucleotide-binding proteins and positive phototactic response of larvae during tree-top disease may have indicated the possible involvement of PDFs thereby regulating 20-hydroxyecdysone (20E), which was found to be a major inducing factor of tree top disease 16 , 41 .…”

Section: Resultsmentioning

confidence: 99%

Phototransduction and circadian entrainment are the key pathways in the signaling mechanism for the baculovirus induced tree-top disease in the lepidopteran larvae

Bhattarai

et al. 2018

Sci Rep

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The tree-top disease is an altered behavioral state, displayed by baculovirus-infected lepidopteran larvae, and characterized by climbing to an elevated position before death. The detailed molecular mechanism underlying this phenomenal behavior change has not been reported yet. Our study focused on the transcriptomic changes in the host larvae due to baculovirus infection from pre-symptomatic to tree-top disease stage. Enrichment map visualization of the gene sets grouped based on the functional annotation similarity revealed 34 enriched pathways in signaling mechanism cluster during LdMNPV induced tree-top disease in third instar Lymantria dispar asiatica larvae. Directed light bioassay demonstrated the positively phototactic larvae during tree-top disease and the gene expression analysis showed altered rhythmicity of the host’s core circadian genes (per and tim) during the course of infection emphasizing the role of Circadian entrainment and Phototransduction pathways in the process, which also showed maximum interactions (>50% shared genes with 24 and 23 pathways respectively) among other signaling pathways in the enrichment map. Our study provided valuable insights into different pathways and genes, their coordinated response and molecular regulation during baculovirus infection and also improved our understanding regarding signaling mechanisms in LdMNPV induced tree-top disease.

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“…Instead, the climbing behaviour appeared to be moultingrelated. Using RNAi and exogenous hormone treatment, a recent report showed that 20-hydroxyecdysone (20E), a substrate of EGT, inhibited virus-induced tree-top disease in HearNPVinfected larvae [61]. One possible explanation is that the higher 20E hormone titre may trigger apolysis, leading to an immobilized state of larvae and death at lower positions.…”

Section: (B) Enhanced Locomotory Activity and Virus Disseminationmentioning

confidence: 99%

Cross-talking between baculoviruses and host insects towards a successful infection

Wang

2019

Phil. Trans. R. Soc. B

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Baculoviridae is a family of large DNA viruses that infect insects. They have been extensively used as safe and efficient biological agents for the control of insect pests. As a result of coevolution with their hosts, baculoviruses developed unique life cycles characterized by the production of two distinctive virion phenotypes, occlusion-derived virus and budded virus, which are responsible for mediating primary infection in insect midgut epithelia and spreading systemic infection within infected insects, respectively. In this article, advances associated with virus -host interactions during the baculovirus life cycle are reviewed. We mainly focus on how baculoviruses exploit versatile strategies to overcome diverse host barriers and establish successful infections. For example, in the midgut, baculoviruses encode enzymes to degrade peritrophic membranes and use a series of per os infectivity factors to initiate primary infection. A viral fibroblast growth factor is expressed to attract tracheoblasts that spread the virus for systemic infection. Baculoviruses use different strategies to suppress host defence systems, including apoptosis, melanization and RNA interference. Additionally, baculoviruses can manipulate host physiology and induce 'tree-top disease' for optimal virus replication and dispersal. These advances in our understanding of baculoviruses will greatly inform the development of more effective baculoviral pesticides.This article is part of the theme issue 'Biotic signalling sheds light on smart pest management'.

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Host miRNAs are involved in hormonal regulation of HaSNPV‐triggered climbing behaviour in Helicoverpa armigera

Cited by 36 publications

References 50 publications

Diversity of Insect Sesquiterpenoid Regulation

Diversity of Insect Sesquiterpenoid Regulation

Phototransduction and circadian entrainment are the key pathways in the signaling mechanism for the baculovirus induced tree-top disease in the lepidopteran larvae

Cross-talking between baculoviruses and host insects towards a successful infection

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