Host Lipid Manipulation by Intracellular Bacteria: Moonlighting for Immune Evasion

Challagundla, Naveen; Phadnis, Deepti; Gupta, Aakriti; Agrawal-Rajput, Reena

doi:10.1007/s00232-023-00296-8

Cited by 1 publication

(1 citation statement)

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“…In the mice macrophages, Salmonella typhimurium promoted its intracellular replication through the up-regulation of host glycolysis and a decrease in host serine synthesis process, which would provide carbon sources for bacteria and increase the production of bacterial virulence factors [17]. Host lipids can be hijacked by bacteria to meet their energy needs or to hide themselves from the host cell [18]. Notably, the potential regulatory tandem of inflammatory response and amino acid metabolism, such as the biosynthesis of phenylalanine, tyrosine, and tryptophan and the metabolism of phenylalanine, has important functions in adaptive and innate immunity [19].…”

Section: Discussionmentioning

confidence: 99%

Different Immune Responses of Hemocytes from V. parahaemolyticus-Resistant and -Susceptible Shrimp at Early Infection Stage

Du,

Li,

2024

Biology

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Vibrio parahaemolyticus is one of the main causative agents leading to acute hepatopancreatic necrosis disease, the severe bacterial disease that occurs during shrimp aquaculture. Hemocytes play important roles during Vibrio infection. Previously, we found that there were few differentially expressed genes (DEGs) between hemocytes from V. parahaemolyticus-resistant and -susceptible shrimp before infection. We considered that there should be different immune responses between them after a pathogen infection. Here, the transcriptome data of hemocytes from V. parahaemolyticus-resistant and -susceptible shrimp before and after a pathogen infection were compared. The results showed that there were 157 DEGs responsive to infection in V. parahaemolyticus-resistant shrimp, while 33 DEGs in V. parahaemolyticus-susceptible shrimp. DEGs in V. parahaemolyticus-resistant shrimp were mainly related to immune and glycolytic processes, while those in V. parahaemolyticus-susceptible shrimp were mainly related to metabolism, with only two DEGs in common. A further analysis of genes involved in glucose metabolism revealed that GLUT2, HK, FBP, and PCK1 were lowly expressed while PC were highly expressed in hemocytes of the V. parahaemolyticus-resistant shrimp, indicating that glucose metabolism in shrimp hemocytes was related to a V. parahaemolyticus infection. After the knockdown of PC, the expression of genes in Toll and IMD signaling pathways were down-regulated, indicating that glucose metabolism might function through regulating host immunity during V. parahaemolyticus infection. The results suggest that the immune responses between V. parahaemolyticus-resistant and -susceptible shrimp were apparently different, which probably contribute to their different V. parahaemolyticus resistance abilities.

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Section: Discussionmentioning

confidence: 99%