Suganya Selvarajah, Leslie H Tobler, Graham Simmons, Michael P Busch
AbstractPurpose of review-Host genetic factors influencing HCV transmission outcomes are incompletely defined. However, vast differences observed in rates of spontaneous clearance between individuals infected with the same parental HCV strain strongly indicate a role for genetic determinants in the host immune response to HCV. This review discusses genetic association studies, particularly those published in the past year, that show gene linkages with spontaneous and treatment-induced HCV clearance. The valua…
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