Host Factors, UV Radiation, and Risk of Uveal Melanoma

Sun exposure predicts risk of ocular melanoma in Australia

“…The lack of evidence in our study of an association between choroid and ciliary body melanoma and ambient solar radiation at the birthplace or accumulated over all places of residence contrasts with the quite strong, but not completely consistent, associations of ocular melanoma with birth 2 or long-term residence 3 in southern parts of the United States (Table IV). There is, however, little evidence from studies of incidence of eye cancer or ocular melanoma by latitude to support these latter observations.…”

“…No previous study has compared men and women with respect to associations of total or occupational sun exposure with ocular melanoma. We found little or no evidence, as did previous studies, [1][2][3][4] that time outdoors on nonworking days, on holidays or in specific recreational activities influenced risk of ocular melanoma; there was little difference between men and women in this respect. Perhaps sun exposure is more relevant to ocular melanoma when more continuous, as in exposure on working days, than when intermittent, as in recreational activities.…”

Sun exposure predicts risk of ocular melanoma in Australia

“…The lack of evidence in our study of an association between choroid and ciliary body melanoma and ambient solar radiation at the birthplace or accumulated over all places of residence contrasts with the quite strong, but not completely consistent, associations of ocular melanoma with birth 2 or long-term residence 3 in southern parts of the United States (Table IV). There is, however, little evidence from studies of incidence of eye cancer or ocular melanoma by latitude to support these latter observations.…”

“…No previous study has compared men and women with respect to associations of total or occupational sun exposure with ocular melanoma. We found little or no evidence, as did previous studies, [1][2][3][4] that time outdoors on nonworking days, on holidays or in specific recreational activities influenced risk of ocular melanoma; there was little difference between men and women in this respect. Perhaps sun exposure is more relevant to ocular melanoma when more continuous, as in exposure on working days, than when intermittent, as in recreational activities.…”

Incidence of ocular melanoma in Australia from 1990 to 1998

“…Incidence varied by region of birth in our series. Migrants to Australia from Southern Europe had the lowest incidence of all migrants from Europe, a finding consistent with the significantly lower risk in people of Southern European ancestry than all other ancestries in a U.S. case‐control study 27. In our incidence survey, people born in Asia had the lowest rates of ocular melanoma.…”

Ambient ultraviolet radiation and ocular melanoma incidence in the United States, 2000−2019

“…Our null results for total ocular melanoma were consistent with two studies each that reported no relationships with latitude and modelled UVR exposure for all ocular melanoma [10,14]. A number of studies of uveal melanoma also reported no relationship for surrogates of solar UVR exposure (e.g., modelled ambient UVR [11,13], occupational sun exposure [15], sun exposure during vacation [12], eye protection [19], and others [9,13]). However, other UVR surrogates did point to a suggestive positive association with risks of uveal melanoma for higher occupational sun exposure [19] and lack of eye protection [9,13].…”

Sun exposure predicts risk of ocular melanoma in Australia

“…The lack of evidence in our study of an association between choroid and ciliary body melanoma and ambient solar radiation at the birthplace or accumulated over all places of residence contrasts with the quite strong, but not completely consistent, associations of ocular melanoma with birth 2 or long-term residence 3 in southern parts of the United States (Table IV). There is, however, little evidence from studies of incidence of eye cancer or ocular melanoma by latitude to support these latter observations.…”

“…No previous study has compared men and women with respect to associations of total or occupational sun exposure with ocular melanoma. We found little or no evidence, as did previous studies, [1][2][3][4] that time outdoors on nonworking days, on holidays or in specific recreational activities influenced risk of ocular melanoma; there was little difference between men and women in this respect. Perhaps sun exposure is more relevant to ocular melanoma when more continuous, as in exposure on working days, than when intermittent, as in recreational activities.…”

Incidence of ocular melanoma in Australia from 1990 to 1998

“…Incidence varied by region of birth in our series. Migrants to Australia from Southern Europe had the lowest incidence of all migrants from Europe, a finding consistent with the significantly lower risk in people of Southern European ancestry than all other ancestries in a U.S. case‐control study 27. In our incidence survey, people born in Asia had the lowest rates of ocular melanoma.…”

Ambient ultraviolet radiation and ocular melanoma incidence in the United States, 2000−2019

“…Our null results for total ocular melanoma were consistent with two studies each that reported no relationships with latitude and modelled UVR exposure for all ocular melanoma [10,14]. A number of studies of uveal melanoma also reported no relationship for surrogates of solar UVR exposure (e.g., modelled ambient UVR [11,13], occupational sun exposure [15], sun exposure during vacation [12], eye protection [19], and others [9,13]). However, other UVR surrogates did point to a suggestive positive association with risks of uveal melanoma for higher occupational sun exposure [19] and lack of eye protection [9,13].…”

Sun exposure predicts risk of ocular melanoma in Australia

“…The lack of evidence in our study of an association between choroid and ciliary body melanoma and ambient solar radiation at the birthplace or accumulated over all places of residence contrasts with the quite strong, but not completely consistent, associations of ocular melanoma with birth 2 or long-term residence 3 in southern parts of the United States (Table IV). There is, however, little evidence from studies of incidence of eye cancer or ocular melanoma by latitude to support these latter observations.…”

“…No previous study has compared men and women with respect to associations of total or occupational sun exposure with ocular melanoma. We found little or no evidence, as did previous studies, [1][2][3][4] that time outdoors on nonworking days, on holidays or in specific recreational activities influenced risk of ocular melanoma; there was little difference between men and women in this respect. Perhaps sun exposure is more relevant to ocular melanoma when more continuous, as in exposure on working days, than when intermittent, as in recreational activities.…”

Incidence of ocular melanoma in Australia from 1990 to 1998

“…Incidence varied by region of birth in our series. Migrants to Australia from Southern Europe had the lowest incidence of all migrants from Europe, a finding consistent with the significantly lower risk in people of Southern European ancestry than all other ancestries in a U.S. case‐control study 27. In our incidence survey, people born in Asia had the lowest rates of ocular melanoma.…”

Ambient ultraviolet radiation and ocular melanoma incidence in the United States, 2000−2019

“…Our null results for total ocular melanoma were consistent with two studies each that reported no relationships with latitude and modelled UVR exposure for all ocular melanoma [10,14]. A number of studies of uveal melanoma also reported no relationship for surrogates of solar UVR exposure (e.g., modelled ambient UVR [11,13], occupational sun exposure [15], sun exposure during vacation [12], eye protection [19], and others [9,13]). However, other UVR surrogates did point to a suggestive positive association with risks of uveal melanoma for higher occupational sun exposure [19] and lack of eye protection [9,13].…”