Hospitalization vs Outpatient Treatment of Young Febrile Infants: 10-Year Comparison

PCR-based diagnostics for infectious diseases: uses, limitations, and future applications in acute-care settings

“…Bacterial causes of meningitis can be highly aggressive but generally cannot be differentiated on a clinical basis from aseptic meningitis, a benign condition generally appropriate for outpatient management. 61 Culture methods often take several days to show positive results and are confounded by poor sensitivity or false-negative findings in patients receiving empiric antimicrobials. 62 One well developed assay, which has the potential to influence the management of patients in the acute-care setting, allows early and rapid diagnosis of diseases of viral cause.…”

Aetiology and Management of Children With Acute Fever of Unknown Origin

“…[114,119] However, there has been an increased trend towards the individualised approach and outpatient management using intramuscular ceftriaxone in the last decade. [140] The extent of definitive work-up for sepsis is another source of controversy. For example, lumbar puncture has been considered mandatory because meningitis complicates neonatal sepsis in up to one-third of babies, [19] whereas up to 15% of those with meningitis lack demonstrable bacteraemia, [130,141] and reliance on blood culture alone would limit the ability to identify the causative agent.…”