Hospitalization for hypoglycaemia in people with diabetes in Denmark, 1997–2017: Time trends in incidence and HbA_1c and glucose‐lowering drug use before and after hypoglycaemia

Abstract

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Medication-Related Hospital Admissions and Emergency Department Visits in Older People with Diabetes: A Systematic Review

“…Overall, this review shows that hypoglycaemia-related hospitalisations or ED visits have declined since 2015. Although the trends in hospitalisations or ED visits seem to portray a similar pattern, there was considerable diversity in incidence rates between countries, with the lowest incidence rate (22 events per 100,000 people in 2017) being reported in Denmark [45]. Various studies that also observed the trend in antidiabetic drug use during the time found a decrease in the use of medications that have a high contribution to hypoglycaemia incidents [34,46,48].…”

“…Ultimately, 35 studies met the pre-defined inclusion criteria , of which 8 studies were identified through citation analysis. Studies were published between 2005 and 2023 and conducted mainly in the United States (US) (n = 7) [24,26,36,42,47,49,52], Italy (n = 6) [23,29,31,33,41,53], Korea (n = 4) [30,38,48,55], Denmark (n = 2) [45,46], Germany (n = 2) [25,43], Greece (n = 2) [22,28], Japan (n = 2) [37,56], Portugal (n = 2) [35,44], Taiwan (n = 2) [32,50], Malta (n = 1) [51], Pakistan (n = 1) [27], France (n = 1) [54], Spain (n = 1) [39], Thailand (n = 1) [40], and the United Kingdom (UK) (n = 1) [34].…”

“…In terms of study orientation, the majority were retrospective studies (n = 29), with study designs varying from analytical cross-sectional (n = 16) [22,24,[29][30][31]33,35,40,43,48,[50][51][52][53]55,56], cohort (n = 10) [25,26,32,34,36,41,42,46,47,49], prevalence (descriptive crosssectional) (n = 6) [23,27,37,39,44,54], to case-control (n = 3) [28,38,45]. Most studies (60%) were rated as being high quality (Tables S4-S7) [23,24,30,32,[35][36][37][38][39][40][41][43][44]…”

“…The included studies used objective criteria obtained from medical records (n = 18) [22,23,[27][28][29]31,33,[35][36][37]39,44,47,[49][50][51]53,54,56], administrative databases (n = 12) [24,26,30,32,38,42,43,45,46,48,55], patients' registries (n = 4) [25,34,40,52] or a combination of sources (n = 1) [41] to identify patients, their characteristics, and the study outcomes. The outcomes observed, hospital admissions and/or ED visits, were predominantly recorded using the International Classification of Diseases 10th Revision (ICD-10) (n = 14) [30,34,36,42,43,[45][46][47][48][49]52,[54][55]…”

“…Of the 35 included studies, 25 (71.4%) reported on the events, while the remaining 10 (28.6%) reported on trends in hospitalisation or ED visits between 1996 and 2019 in patients with mean ages ranging from 60.5 ± 14.2 to 84.7 ± 4.3 years. The trends in medication-related hospitalisations or ED visits were reported as incidence (events per person-years) [43,45,46,48,49,52,55], annual percent change [34] and percentage [36,44]. Of the majority of studies reporting the trends as incidence in the type 2 diabetes population during the early 2000s [43,46,48,49,55], values ranged between 356 and 1100 events per 100,000 person-years.…”