Hospitalised Malaysian children with pandemic (H1N1) 2009 influenza: clinical characteristics, risk factors for severe disease and comparison with the 2002-2007 seasonal influenza

Koh, Mia Tuang; Eg, Kah Peng; Loh, Soon Shan

doi:10.11622/smedj.2015146

Cited by 7 publications

(15 citation statements)

References 20 publications

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“…There is also another report that showed that absence of nasal congestion is associated with admission thinking of those with nasal congestion can be upper respiratory tract infection compared to young infant presented with fever, but no other focus infection will be hospitalized presumed bacterial sepsis. The most commonly infected ethnic groups were Malays (61.5%), Chinese (20.6%) and Indians (16%) which reflected in sampled ethnicity (Koh et al, 2016). Another paper showed that male gender is associated with hospitalization (Quach et al, 2003); similar to a few other papers showed that male was higher among positive influenza cases (Khor et al, 2012); Lin et al, 2012(Koh et al, 2016.…”

Section: Risk Factors and Influenza Virus Infection Among Childrenmentioning

confidence: 68%

“…The most commonly infected ethnic groups were Malays (61.5%), Chinese (20.6%) and Indians (16%) which reflected in sampled ethnicity (Koh et al, 2016). Another paper showed that male gender is associated with hospitalization (Quach et al, 2003); similar to a few other papers showed that male was higher among positive influenza cases (Khor et al, 2012); Lin et al, 2012(Koh et al, 2016. Non-modifiable such as gender and ethnicity contribute to the occurrence of influenza infection among children.…”

Section: Risk Factors and Influenza Virus Infection Among Childrenmentioning

confidence: 74%

“…Generally, influenza virus infection occurred throughout the year in tropical countries such as Malaysia with no clear seasonality (Sam, 2015). This is supported by Koh and colleagues whereby seasonality is less clear for influenza virus compared to the respiratory syncytial virus (RSV) which presented with an annual epidemic with a strong seasonal pattern (Koh et al, 2016). In 2005 -2009, influenza viruses were commonly isolated from May to August (Saat et al, 2010).…”

Section: Seasonalitymentioning

confidence: 94%

“…Many studies reported that influenza viruses in tropical countries such as Malaysia were found to be all year-round with higher occurrence in the middle of the year. Another study also mentioned that influenza cases reported no seasonality with peaking between November -January and May -July (Koh et al, 2016). There are usually few influenza virus strains (3 to 6) co-circulating simultaneously every year.…”

Section: Seasonalitymentioning

confidence: 99%

“…In Thailand, across all age groups between 2005 and 2008 have shown that influenza virus infection was associated with 10.4% of hospitalised pneumonia cases and the highest incidence was seen mainly in children under 5 years old and adults over 75 years old (Sam, 2015;Simmerman et al, 2009). Hospitalization rates for children below 5 years old with seasonal influenza were estimated to be 1.4 per 100,000 in the USA (Bourgeois et al, 2009), countries in Southeast Asia rates vary in different countries such as Singapore (0.7 -0.9) (Koh et al, 2016), Thailand (2.4) and Vietnam (3.9 -4.7) (Sam, 2015). The incidence of influenza-associated ALRI among children less than 6 months was roughly 1.6 times higher than children of 6 -11 months.…”

Section: The Burden Of Influenza In Childrenmentioning

confidence: 99%

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The Burden of Influenza Virus Infection among Children under 12 Years Old in Tropical Countries

Lim

Ibrahim

Hassan

et al. 2021

BJMS

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Every year influenza epidemic causes about 3 – 5 million severe respiratory infections and 250,000 to 500,000 deaths worldwide. Among them about 28,000 – 111,500 (11 – 22%) children under 5 years old die because of influenza-related acute lower respiratory tract infections. This review aims to explore the burden, risk factors and seasonality related to influenza virus infection among children under 5 years old in tropical countries. From 1st to 31st December 2020 literature search was done on PubMed and ScienceDirect databases using ‘influenza’ and other keywords such as paediatric, children, neurology complication and breastfeeding for articles published in the English language. About 10% of hospitalization with respiratory infections in children <18 years old are related to influenza. It is reported that about 11% – 26% of febrile illnesses among outpatients and 6 –14% of hospitalized patients with pneumonia were due to influenza virus. Global paediatric mortality estimates that death caused by influenza is highest among 1 – 12 months old children which is about 2.8% of all deaths. In Malaysia, there are no seasonal variations of influenza and the prevalence is higher during the middle of the year. Risk factors include male, age <12 months old and presented with seizure. Breastfeeding and vaccination for pregnant mothers can be beneficial for infants up to 6 months old. Influenza among the paediatric group is a significant health burden even in healthy children and are likely to be underdiagnosed. Vaccination can also be focused on pregnant mothers and children less than 12 years old.

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Section: Risk Factors and Influenza Virus Infection Among Childrenmentioning

confidence: 68%

Section: Risk Factors and Influenza Virus Infection Among Childrenmentioning

confidence: 74%

Section: Seasonalitymentioning

confidence: 94%

Section: Seasonalitymentioning

confidence: 99%

Section: The Burden Of Influenza In Childrenmentioning

confidence: 99%

See 3 more Smart Citations

The Burden of Influenza Virus Infection among Children under 12 Years Old in Tropical Countries

Lim

Ibrahim

Hassan

et al. 2021

BJMS

View full text Add to dashboard Cite

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Identification of Newly Emerging Influenza Viruses by Detecting the Virally Infected Cells Based on Surface Enhanced Raman Spectroscopy and Principal Component Analysis

et al. 2019

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Rapid diagnosis and quarantine of influenza virus mutant-infected people is critical to contain the fatal viral infection spread because effective antiviral drugs are normally not available. Conventional methods, however, cannot be used for the diagnosis because these methods need predefined labels, likely also unavailable for just emerging viruses. Here, we propose label-free identification of cells infected with different influenza viruses based on surface-enhanced Raman spectroscopy (SERS) and principal component analysis (PCA). Viral envelope proteins that are displayed on the surface of cells after infection of influenza viruses were targeted for this identification. Cells that expressed the envelope proteins of A/WSN/33 H1N1 or A/California/04/2009 H1N1 influenza viruses produced distinct SERS signals. Cells that displayed combinations of the envelope proteins from these two viral variants, an indication of emergence of a new virus, also generated characteristic SERS patterns. However, the cell’s own surface proteins often hindered the identification of virally infected cells by producing SERS peaks similar to viral ones. PCA of the obtained SERS patterns could effectively capture the virus-specific signal components from the jumbled SERS peaks. Our study demonstrates a potential of combination of SERS and PCA to identify newly emerging influenza viruses through sensing the cells infected with the viruses.

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Influenza and other respiratory viruses: standardizing disease severity in surveillance and clinical trials

Rath

Conrad

Myles

et al. 2017

Expert Review of Anti-infective Therapy

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Influenza-Like Illness is a leading cause of hospitalization in children. Disease burden due to influenza and other respiratory viral infections is reported on a population level, but clinical scores measuring individual changes in disease severity are urgently needed. Areas covered: We present a composite clinical score allowing individual patient data analyses of disease severity based on systematic literature review and WHO-criteria for uncomplicated and complicated disease. The 22-item ViVI Disease Severity Score showed a normal distribution in a pediatric cohort of 6073 children aged 0-18 years (mean age 3.13; S.D. 3.89; range: 0 to 18.79). Expert commentary: The ViVI Score was correlated with risk of antibiotic use as well as need for hospitalization and intensive care. The ViVI Score was used to track children with influenza, respiratory syncytial virus, human metapneumovirus, human rhinovirus, and adenovirus infections and is fully compliant with regulatory data standards. The ViVI Disease Severity Score mobile application allows physicians to measure disease severity at the point-of care thereby taking clinical trials to the next level.

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Hospitalised Malaysian children with pandemic (H1N1) 2009 influenza: clinical characteristics, risk factors for severe disease and comparison with the 2002-2007 seasonal influenza

Cited by 7 publications

References 20 publications

The Burden of Influenza Virus Infection among Children under 12 Years Old in Tropical Countries

The Burden of Influenza Virus Infection among Children under 12 Years Old in Tropical Countries

Identification of Newly Emerging Influenza Viruses by Detecting the Virally Infected Cells Based on Surface Enhanced Raman Spectroscopy and Principal Component Analysis

Influenza and other respiratory viruses: standardizing disease severity in surveillance and clinical trials

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