1998
DOI: 10.1001/archderm.134.11.1356
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Horse-Chestnut Seed Extract for Chronic Venous Insufficiency

Abstract: To assess the evidence for or against horse-chestnut seed extract (HCSE) as a symptomatic treatment of chronic venous insufficiency (CVI). Data Sources: Computerized literature searches were performed in MEDLINE, EMBASE, BIOSIS, CISCOM, and the Cochrane Library (all from their respective institution to December 1996). The search terms were "horse chestnut," "Aesculus hippocastanum," "escin," and "Rosskastanie" (German for "horse chestnut"). There were no restrictions on the language of publication. Study Selec… Show more

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Cited by 123 publications
(37 citation statements)
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References 16 publications
(24 reference statements)
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“…• ginkgo biloba for cerebral insufficiency [44] and dementias [45,46] • saw palmetto for benign prostate hyperplasia [47] • horse chestnut seed extract for primary varicosis [48] • peppermint oil for irritable bowel syndrome [49] Ginseng is a good example of a widely used HMP that is not backed up by convincing evidence of efficacy. It achieved retail sales of USD 96 million in the United States in 1998 as a BDS, placing it third in this category [50].…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…• ginkgo biloba for cerebral insufficiency [44] and dementias [45,46] • saw palmetto for benign prostate hyperplasia [47] • horse chestnut seed extract for primary varicosis [48] • peppermint oil for irritable bowel syndrome [49] Ginseng is a good example of a widely used HMP that is not backed up by convincing evidence of efficacy. It achieved retail sales of USD 96 million in the United States in 1998 as a BDS, placing it third in this category [50].…”
mentioning
confidence: 99%
“…The pharmacological activities of the Panax ginseng species range from stimulation of the central nervous system to modulation of the immune defense and anabolic effects [48]. The effects of Siberian ginseng are less well researched but claimed to be similar to those of Panax ginseng.…”
mentioning
confidence: 99%
“…70 HCSE, the focus of a Cochrane systematic review, has been shown to improve signs and symptoms of chronic venous insufficiency compared with placebo. 71 One trial suggested that HCSE may be as efficacious as compression therapy for symptom relief. 72 MPFF, like HCSE, has been shown to be effective at relieving the signs and symptoms of chronic venous insufficiency in randomized controlled trials.…”
Section: Topicmentioning
confidence: 99%
“…The HCSE was found to be superior to placebo and as effective as compression therapy in decreasing lower leg volume and leg circumference at the calf and ankle. Symptoms such as leg pain, pruritus, and feeling of fatigue and tenseness were also reduced (211). Side effects are uncommon, but gastrointestinal irritation and toxic nephropathy may occur (212).…”
Section: Herbal Preparationsmentioning
confidence: 99%