Hormones and Their Interaction with the Pain Experience

Vincent, Katy; Tracey, Irene

doi:10.1177/204946370800200206

Cited by 57 publications

(34 citation statements)

References 20 publications

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“…However, these in turn have remarkable adverse effects, such as development of tolerance to opioids, which restricts further administration of these drugs. Regarding the role of steroid hormones in analgesia as a suitable alternative for opioids, the analgesic effects of spexin and the involvement of hippocampus in pain modulation . The present study was conducted to investigate the following two phases of the formalin test: (i) the effect of bilateral intrahippocampal CA3 (IHCA3) microinjection of spexin on pain sensitivity in ovariectomized rats; and (ii) the interaction of spexin IHCA3 microinjection and subcutaneous (s.c.) injection of progesterone on pain sensitivity in this animal model.…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of spexin and progesterone on pain sensitivity attenuation in ovariectomized rats

Moazen

Taherianfard

Ahmadi-Soleimani

et al. 2017

Clin Exp Pharma Physio

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Spexin is a central modulator of nociception. The aim of the present study was to investigate the effect of intra-hippocampal CA3 (IHCA3) injection of spexin and spexin-progesterone co-administration on pain sensitivity in ovariectomized rat. Thirty-five adult female rats were divided into five groups. Sham: the animals received injection of 0.5 μL ACSF by IHCA3. Experiments 1 and 2: the animals received injection of 0.5 μL of spexin bilaterally (10 and 30 nmol/rat respectively). Experiments 3 and 4: the animals received injection of 0.5 μL of spexin bilaterally (10 and 30 nmol/rat respectively) + subcutaneous (s.c.) injection of progesterone (5 mg/kg). Ovariectomy was performed in all groups to eliminate the effects of cyclic changes in the female rats. The formalin test (formalin 2.5%) was performed following the administration of spexin and progesterone. Results showed that bilateral injection of spexin in IHCA3 at both concentrations a significant (P < .05) decrease in the pain sensitivity in the two phases of formalin test. Similarly, the bilateral injection of spexin in IHCA3 at both concentrations following the s.c. injection of progesterone significantly (P < .05) decreases pain sensitivity in two phases of the formalin test. This pain attenuation due to the co-administration of spexin and progesterone was more potent than spexin-induced analgesia. According to the present results, spexin has a modulatory effect on pain sensitivity, which becomes more pronounced by progesterone administration.

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Section: Introductionmentioning

confidence: 99%

Synergistic effect of spexin and progesterone on pain sensitivity attenuation in ovariectomized rats

Moazen

Taherianfard

Ahmadi-Soleimani

et al. 2017

Clin Exp Pharma Physio

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“…This could be due to hormonal factors or difference in muscle mass because CK and BMI showed higher values in males. 16,26 Swallowing impairment is frequently observed in PMM, 27,28 in about 15% of Italian patients with PEO, 27 with females being affected more, probably because of more severe weakness, as already reported. 29 Dysphagia also seems to be a prominent feature in single deletion patients; compared with other genotypes, we found significant worst scores in the swallowing scale in single deletion patients, thus confirming that dysphagia is a canonical feature of this disorder.…”

Section: Discussionmentioning

confidence: 60%

Primary mitochondrial myopathy

et al. 2020

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ObjectiveTo determine whether a set of functional tests, clinical scales, patient-reported questionnaires, and specific biomarkers can be considered reliable outcome measures in patients with primary mitochondrial myopathy (PMM), we analyzed a cohort of Italian patients.MethodsBaseline data were collected from 118 patients with PMM, followed by centers of the Italian network for mitochondrial diseases. We used the 6-Minute Walk Test (6MWT), Timed Up-and-Go Test (x3) (3TUG), Five-Times Sit-To-Stand Test (5XSST), Timed Water Swallow Test (TWST), and Test of Masticating and Swallowing Solids (TOMASS) as functional outcome measures; the Fatigue Severity Scale and West Haven-Yale Multidimensional Pain Inventory as patient-reported outcome measures; and FGF21, GDF15, lactate, and creatine kinase (CK) as biomarkers.ResultsA total of 118 PMM cases were included. Functional outcome measures (6MWT, 3TUG, 5XSST, TWST, and TOMASS) and biomarkers significantly differed from healthy reference values and controls. Moreover, functional measures correlated with patients' perceived fatigue and pain severity. Patients with either mitochondrial or nuclear DNA point mutations performed worse in functional measures than patients harboring single deletion, even if the latter had an earlier age at onset but similar disease duration. Both the biomarkers FGF21 and GDF15 were significantly higher in the patients compared with a matched control population; however, there was no relation with severity of disease.ConclusionsWe characterized a large cohort of PMM by evaluating baseline mitochondrial biomarkers and functional scales that represent potential outcome measures to monitor the efficacy of treatment in clinical trials; these outcome measures will be further reinvestigated longitudinally to define the natural history of PMM.

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“…A bigger number of elderly patients with palliative care than adult patients because mostly elderly patients have more complex problems, such as physical problems affecting their abilities to do their daily activities independently, and mental problems making them feel panicked of their disease diagnosis. Therefore, the palliative care team(s) is needed to assist elderly patients and their families (Davies & Higginson, 2014;Pieretti et al, 2016;Vincent & Tracey, 2008).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Potential Drug Interaction of Analgesic in Cancer Patient Receiving Palliative Care in Dharmais Cancer Hospital

Sitepu¹,

Puspitasari²,

Azmi³

et al. 2020

psr

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Analgesics are mostly used in cancer patients receiving palliative care to improve the quality of life of patients. Besides analgesics, cancer patients receiving palliative care were also given other drugs in combination to overcome other symptoms of cancer, and this combination could potentially cause drug interactions. This study was aimed to analyze the potential of drug interactions with analgesics in cancer patients. The study design was cross-sectional with a retrospective method and descriptive study. The sample of this study was cancer palliative care patient's prescription at Dharmais Cancer Hospital in the period of January-December 2017. The sample analyzed in this study consisted of 273 prescriptions. This study found that there were 191 prescriptions (69.9%) of analgesics which potentially interacted with 316 interaction cases. Fentanyl and morphine with 61 cases (19.3%), morphine and gabapentin with 60 cases (18.9%) and morphine and amitriptyline with 33 cases (10.4%) were observed as the three most analgesics-other drugs interaction. Based on severity levels, there were 73.5% of major interaction, 26.3% of moderate interaction, and 0.2% of minor interaction. This study concluded that high occurrence of drug interactions was observed in analgesic drugs, therefore close monitoring is needed in cancer patient receiving palliative care.

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Hormones and Their Interaction with the Pain Experience

Abstract: • Sex steroid hormones have traditionally been thought to alter transcription; however, there is evidence that there are also non-genomic effects• Sex steroid hormones can have organisational effects from as early as in utero• The relationship between sex hormones and pain is complex

Cited by 57 publications

References 20 publications

Synergistic effect of spexin and progesterone on pain sensitivity attenuation in ovariectomized rats

Synergistic effect of spexin and progesterone on pain sensitivity attenuation in ovariectomized rats

Primary mitochondrial myopathy

Evaluation of Potential Drug Interaction of Analgesic in Cancer Patient Receiving Palliative Care in Dharmais Cancer Hospital

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