Hormone-induced tumor flare

Long-term inhibitory effect of the orally active and pure antiestrogen EM-800 on the growth of human breast cancer xenografts in nude mice

“…Such an estrogenic action of tamoxifen in breast cancer in women is well supported by the tumor flare observed at start of therapy (Clarysse, 1985) as well as by the withdrawal response observed following arrest of tamoxifen in patients who progress under tamoxifen therapy (Howell et al, 1992).…”

Long-term inhibitory effect of the orally active and pure antiestrogen EM-800 on the growth of human breast cancer xenografts in nude mice

“…Such an estrogenic action of tamoxifen in breast cancer in women is well supported by the tumor flare observed at start of therapy (Clarysse, 1985) as well as by the withdrawal response observed following arrest of tamoxifen in patients who progress under tamoxifen therapy (Howell et al, 1992).…”

Flare hypercalcemia after letrozole in a patient with liver metastasis from breast cancer: a case report

“…This reaction comprises two different manifestations: tumor flare and flare hypercalcemia [2]. The former includes an increase in swelling, erythema, itching, or pain in soft-tissue metastasis, the development of new lesions, an increase of tumor markers and an increase in skeletal pain in patients with bone metastasis.…”

“…As for rechallenge of the offending drug, it is usually suggested that, if necessary, tamoxifen be resumed temporarily at a lower dosage in tamoxifen-induced hypercalcemia. This is because tumor regression could occur after the flare reaction subsides and the survival of patients with tamoxifen-induced hypercalcemia is reported to be longer than that of patients with spontaneous hypercalcemia [1,2,8,15]. This strategy also appears to apply to AIs [12].…”

Temozolomide‐induced flare in high‐grade gliomas: a new clinical entity

“…In these tumour types, the flare response is due to the oestrogenic effects of tamoxifen and the short-term effects of luteinizing hormone releasing hormone agonists in prostate cancer. [1][2][3] Some evidence exists suggesting that a flare response is associated with an improved prognosis. 3,5 There are few reports of chemotherapy inducing such a flare response, although individual cases have been described.…”

“…Hormone therapy for metastatic breast cancer and prostate cancer may rarely result in an exacerbation of symptoms, particularly pain from bone metastases. In these tumour types, the flare response is due to the oestrogenic effects of tamoxifen and the short‐term effects of luteinizing hormone releasing hormone agonists in prostate cancer 1−3 . Some evidence exists suggesting that a flare response is associated with an improved prognosis 3,5 …”

Long-term inhibitory effect of the orally active and pure antiestrogen EM-800 on the growth of human breast cancer xenografts in nude mice

“…Such an estrogenic action of tamoxifen in breast cancer in women is well supported by the tumor flare observed at start of therapy (Clarysse, 1985) as well as by the withdrawal response observed following arrest of tamoxifen in patients who progress under tamoxifen therapy (Howell et al, 1992).…”

Flare hypercalcemia after letrozole in a patient with liver metastasis from breast cancer: a case report

“…This reaction comprises two different manifestations: tumor flare and flare hypercalcemia [2]. The former includes an increase in swelling, erythema, itching, or pain in soft-tissue metastasis, the development of new lesions, an increase of tumor markers and an increase in skeletal pain in patients with bone metastasis.…”

“…As for rechallenge of the offending drug, it is usually suggested that, if necessary, tamoxifen be resumed temporarily at a lower dosage in tamoxifen-induced hypercalcemia. This is because tumor regression could occur after the flare reaction subsides and the survival of patients with tamoxifen-induced hypercalcemia is reported to be longer than that of patients with spontaneous hypercalcemia [1,2,8,15]. This strategy also appears to apply to AIs [12].…”

Temozolomide‐induced flare in high‐grade gliomas: a new clinical entity

“…In these tumour types, the flare response is due to the oestrogenic effects of tamoxifen and the short-term effects of luteinizing hormone releasing hormone agonists in prostate cancer. [1][2][3] Some evidence exists suggesting that a flare response is associated with an improved prognosis. 3,5 There are few reports of chemotherapy inducing such a flare response, although individual cases have been described.…”

“…Hormone therapy for metastatic breast cancer and prostate cancer may rarely result in an exacerbation of symptoms, particularly pain from bone metastases. In these tumour types, the flare response is due to the oestrogenic effects of tamoxifen and the short‐term effects of luteinizing hormone releasing hormone agonists in prostate cancer 1−3 . Some evidence exists suggesting that a flare response is associated with an improved prognosis 3,5 …”

Long-term inhibitory effect of the orally active and pure antiestrogen EM-800 on the growth of human breast cancer xenografts in nude mice

“…Such an estrogenic action of tamoxifen in breast cancer in women is well supported by the tumor flare observed at start of therapy (Clarysse, 1985) as well as by the withdrawal response observed following arrest of tamoxifen in patients who progress under tamoxifen therapy (Howell et al, 1992).…”

Flare hypercalcemia after letrozole in a patient with liver metastasis from breast cancer: a case report

“…This reaction comprises two different manifestations: tumor flare and flare hypercalcemia [2]. The former includes an increase in swelling, erythema, itching, or pain in soft-tissue metastasis, the development of new lesions, an increase of tumor markers and an increase in skeletal pain in patients with bone metastasis.…”

“…As for rechallenge of the offending drug, it is usually suggested that, if necessary, tamoxifen be resumed temporarily at a lower dosage in tamoxifen-induced hypercalcemia. This is because tumor regression could occur after the flare reaction subsides and the survival of patients with tamoxifen-induced hypercalcemia is reported to be longer than that of patients with spontaneous hypercalcemia [1,2,8,15]. This strategy also appears to apply to AIs [12].…”

Temozolomide‐induced flare in high‐grade gliomas: a new clinical entity

“…In these tumour types, the flare response is due to the oestrogenic effects of tamoxifen and the short-term effects of luteinizing hormone releasing hormone agonists in prostate cancer. [1][2][3] Some evidence exists suggesting that a flare response is associated with an improved prognosis. 3,5 There are few reports of chemotherapy inducing such a flare response, although individual cases have been described.…”

“…Hormone therapy for metastatic breast cancer and prostate cancer may rarely result in an exacerbation of symptoms, particularly pain from bone metastases. In these tumour types, the flare response is due to the oestrogenic effects of tamoxifen and the short‐term effects of luteinizing hormone releasing hormone agonists in prostate cancer 1−3 . Some evidence exists suggesting that a flare response is associated with an improved prognosis 3,5 …”