Hormonal therapy and depression: Are we overlooking an important therapeutic alternative?

Ancelin, Marie-Laure; Scali, Jacqueline; Ritchie, Karen

doi:10.1016/j.jpsychores.2006.12.019

Cited by 36 publications

(39 citation statements)

References 166 publications

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“…Similar findings have also been reported by other authors 22,23 and it seems that some women are more vulnerable than others to rapid and radical changes in steroid hormone levels 24,25 .…”

Section: Differences In Relation To Other Studiessupporting

confidence: 91%

Elucidating the selectivity of recombinant forms of Aleuria aurantia lectin using weak affinity chromatography

Bergström

Åström

Påhlsson

et al. 2012

Journal of Chromatography B

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Differences in prescription rates and odds ratios of antidepressant drugs in relation to individual hormonal contraceptives: A nationwide population-based study with age-specific analyses, 2012, European journal of contraception & reproductive health care, (17) Results The highest antidepressant OR in all age groups, particularly in the 16-19 years age group, related to medroxyprogesterone-only, followed by etonogestrel-only, levonorgestrel-only and ethinylestradiol/norelgestromin formulations. Oral contraceptives containing ethinylestradiol combined with lynestrenol or drospirenone had considerably higher ORs than other pills. ORs significantly lower than 1 were observed when ethinylestradiol was combined with norethisterone, levonorgestrel or desogestrel. ConclusionThe association between use of hormonal contraceptives and antidepressant drugs varies considerably within both the combined hormonal contraceptive and the progestin-only groups.3

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“…Similar findings have also been reported by other authors 22,23 and it seems that some women are more vulnerable than others to rapid and radical changes in steroid hormone levels 24,25 .…”

Section: Differences In Relation To Other Studiessupporting

confidence: 91%

Elucidating the selectivity of recombinant forms of Aleuria aurantia lectin using weak affinity chromatography

Bergström

Åström

Påhlsson

et al. 2012

Journal of Chromatography B

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“…113 Black cohosh and St. John’s wort have demonstrated short-term benefits for perimenopausal depression, 113 whereas light therapy, S-adenosylmethionine, and folate have shown benefits for major depression in women. 135 A healthy lifestyle of exercise and a diet limited in caffeine may improve mood symptoms. 79,135 …”

Section: Premenstrual Exacerbation Of Preexisting Mental Health Disormentioning

confidence: 99%

“…135 A healthy lifestyle of exercise and a diet limited in caffeine may improve mood symptoms. 79,135 …”

Section: Premenstrual Exacerbation Of Preexisting Mental Health Disormentioning

confidence: 99%

Menstrual cycle-related exacerbation of disease

Pinkerton¹,

Guico-Pabia²,

Taylor³

2010

American Journal of Obstetrics and Gynecology

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Exacerbation of common medical and mental health disorders at specific phases of the menstrual cycle is a prevalent phenomenon. Although the precise cause is unclear, studies implicate complex interactions between the immune and neuroendocrine systems. The menstrual cycle also is a trigger for the onset of depressive disorders, including premenstrual dysphoric disorder, a disorder specific to the luteal phase of the menstrual cycle, and depression associated with the transition to menopause. This article discusses common mental health problems exacerbated by the menstrual cycle, with a particular focus on premenstrual dysphoric disorder and perimenopausal depression. Throughout the reproductive lifespan, routine screening and assessment for the presence of common psychiatric disorders are critical for accurate diagnosis and provision of effective treatment. Management options include referral or consultation with a primary care provider or psychiatrist; treatment options for premenstrual dysphoric disorder and perimenopausal depression include pharmacotherapy with antidepressant agents and/or psychotherapy. Hormones may be helpful.

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“…Hormones such as estradiol, prolactin and cortisol peak during the last few weeks of pregnancy, followed by a drastic drop in levels following delivery and into the early postpartum period (Abou-Saleh et al, 1998;Ancelin et al, 2007). The rate of change in the hormone levels that occurs from pre-pregnancy to post-delivery is considered a key determinant in the increase in depressive symptoms and risk of PPMD (Ancelin, Scali, and Ritchie, 2007;Bloch, Daly, and Rubinow, 2003;Soares et al, 2008). Similarly, the `cytokine hypothesis of depression' states that both the etiology and pathophysiology of depression are linked to dysregulation of inflammatory cytokines (Maes, 1994).…”

Section: Introductionmentioning

confidence: 99%

Changes in sleep quality, but not hormones predict time to postpartum depression recurrence

Okun

Luther

Prather

et al. 2011

Journal of Affective Disorders

139

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Background-Poor sleep quality, dysregulation of hormones and increased inflammatory cytokines are all associated with risk for postpartum major depression (PPMD). We evaluated change over time in sleep quality and hormones during the first 17-weeks postpartum, as well as a single cytokine measure, and their association with PPMD recurrence.Methods-Participants were pregnant women (N = 56), with past histories of MDD/PPMD but not depressed in their current pregnancy. The Pittsburgh Sleep Quality Index (PSQI) and blood samples were collected 8 times during the first 17 weeks postpartum. Estradiol, prolactin and cortisol, and a single measure of IL-6 were assayed. Recurrence was determined by two consecutive 21-item Hamilton Rating Scale for Depression (HRSD) scores ≥ 15 and clinician interview.Results-In analyses of time to PPMD recurrence, poor sleep quality, but none of the hormones, was associated with PPMD recurrence (p < .05) after controlling for medication assignment. With every one point increase in PSQI scores across time, a woman's risk for recurrence increased by Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Conflict of Interest Dr. Wisner's time was supported by National Institute of Mental Health grants MH R01 60335 and MH R01 53735. Dr. Wisner is a member of the speakers' bureau for GlaxoSmithKline and has received grant support from Pfizer, funding from Wyeth to study desmethylvenlafaxine for postpartum depression is pending. No pharmaceutical companies were involved in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript. Drs. Okun, Perel, and Wisniewski and Mrs. Luther and Prather report no competing interests. Dr. Okun's time was supported by NR 08103.Disclosure Statement This is not an industry supported study. Dr. Wisner received a donation from Novo-Gyne of transdermal placebo patches for an NIMH funded study of estradiol patch for postpartum depression treatment. Dr. Wisner also serves on an Advisory Board for Eli Lilly Corporation. The remaining authors have indicated no biomedical financial interests or other conflicts of interest. approximately 25% There was no significant association between PSQI scores and IL-6 concentrations in early postpartum (χ 2 = 0.98, p = .32). NIH Public AccessConclusions-Poor sleep quality across the first 17 weeks post delivery increases the risk for recurrent PPMD among women with a history of MDD. Changes in the hormonal milieu were not associated with recurrence. Further exploration of the degree to...

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Hormonal therapy and depression: Are we overlooking an important therapeutic alternative?

Cited by 36 publications

References 166 publications

Elucidating the selectivity of recombinant forms of Aleuria aurantia lectin using weak affinity chromatography

Elucidating the selectivity of recombinant forms of Aleuria aurantia lectin using weak affinity chromatography

Menstrual cycle-related exacerbation of disease

Changes in sleep quality, but not hormones predict time to postpartum depression recurrence

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