Hormonal Regulation of Renal Ornithine Decarboxylase Activity in the Rat<sup>1</sup>

Nicholson, Wendell E.; Levine, Jon H.; Orth, David N.

doi:10.1210/endo-98-1-123

Cited by 45 publications

(16 citation statements)

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“…The effects of somatotropin of varying degrees of purity tend to correlate inversely with the estimates of CRG in the untreated. A marked enhanc ement of CRG but less than in normal controls is re ported in experiments in which relatively little CRG was found in untreated [24,166] and little or none in those with significant untreated CRG [359,422,425]. The latter conclusion is supported by the observation of near-nor mal CRG in mice with congenital deficiency of prolactin and thyro-and somatotropin [39,237],…”

Section: Hormonesmentioning

confidence: 93%

“…The conflicting results might reflect varying degress of purity of extracts. The relative contribution of somatotropin alone to kidney size is measured by a K / B ratio 20% lower than normals in somatotropin-deficient mice [237], So matotropin, adrenocorticotropin and cortisol to a lesser extent, but not gonadotropins, thyrotropin or prolactin increased ornithine decarboxylase activity in hypophy sectomized rats [359].…”

Section: Hormonesmentioning

confidence: 99%

“…The results of replacement by one or more pituitary principles in UNX rats show no significant effects from adrenotropin [23,359], thyrotropin [359], thyroxine [422] or prolactin [24]. The effects of somatotropin of varying degrees of purity tend to correlate inversely with the estimates of CRG in the untreated.…”

Section: Hormonesmentioning

confidence: 99%

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Compensatory Growth and Other Growth Responses of the Kidney

Wesson

1989

Nephron

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Section: Hormonesmentioning

confidence: 93%

Section: Hormonesmentioning

confidence: 99%

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Compensatory Growth and Other Growth Responses of the Kidney

Wesson

1989

Nephron

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“…Therefore, it has been proposed that polyamines mediate some growth-promoting actions of GH. That the biosynthesis of the polyamines is not under the sole control of GH, however, is demonstrated by the rises in ODC activity caused by other hormonal factors (2,16).…”

Section: Introductionmentioning

confidence: 99%

Serum and Urine Polyamines in Normal and in Short Children

Rudman¹,

Kutner²,

Chawla³

et al. 1979

J. Clin. Invest.

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A B S T R A C T The serum and urine polyamines putrescine, spermidine, and spermine were measured in 112 normal subjects from 0 to 70 yr of age, and in three groups of short children from 7 to 20 yr: 21 growth hormone (GH) deficient patients, 20 normal variant short stature children, and 9 girls with 45, X Turner's syndrome. Urine polyamines were expressed as micromoles per gram of creatinine or per kilogram body weight, and serum polyamines were expressed as nanomoles per milliliter.In normals, the three polyamines were highest in urine and serum at birth. The mean levels declined progressively with age, the rate of change decreasing with age. The mean for the normal subjects, and its 95% confidence and prediction intervals, were estimated from birth to age 70 for each serum and urine polyamine.In GH-deficient children, serum and urine values were significantly lower (P < 0.05) than the agespecific normal values (with the exception of serum spermidine and spermine), averaging 25-55% below normal. This abnormality was corrected during 1 wk of treatment with human GH. In Turner's syndrome, serum and urine values were significantly reduced (P < 0.05), averaging 35-80% below age-specific normals. GH treatment had no corrective effect.In 6 of 20 normal variant short stature children, polyamine levels were significantly (P < 0.01) subnormal, averaging 50-80% below age-specific normals in both serum and urine. Treatment with GH had no corrective effect.These data show that levels of polyamines in serum and urine are correlated with linear growth primarily during the first decade of life. Subnormal polyamine levels are generally associated with growth retardation.

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“…Thus, high activity of ODC and increased SPD/SP are present in tissues of rapidly growing young animals (8,9), in regenerating rat liver (lo), in compensatory or adaptive hypertrophy of renal and cardiac tissue (2,3), and in various tumors (8). Moreover, the circadian variation in renal ODC activity may be attributed to physiologic fluctuations in plasma GH levels in rats (14). Evidence for such physiologic association between GH activity and polyamine synthesis has also been found in human fetuses.…”

Section: Discussionmentioning

confidence: 99%

Blood Cell Polyamines in Children with Short Stature in Reference to Growth Hormone Activity

et al. 1980

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SummaryThe molar ratio of two blood polyamines (spermidine to spermine) was investigated in 54 children with shortness of stature. The long-term reproducibility of this ratio was 9.0%. In children with no endocrine disturbances, the mean ratio was 0.97. In children with isolated growth hormone deficiency, it was 0.61, and in those with growth bormone and ACTH deficiency, it was 0.67, both significantly low values. The ratio showed a significant positive correlation with growth hormone response to insulin hypoglycemia (r = 0.58; P < 0.001) and with the nitrogen retention response to short-term growth hormone therapy (r = 0.45; P < 0.001). In contrast, no such correlation was present with cortisol response to hypoglycemia. SpeculationThe association of decreased growth hormone activity with decreased polyamhe synthesis in man agrees with data obtained in vitro and in animals. Growth hormone seems to be a direct regulator of the synthesis of polyamines, which have essential functions in cellular metabolism.Three polyamines, putrescine, spermidine (SPD), and spermine (SP), are associated with several biochemical events of tissue growth, including protein and nucleic acid synthesis and metabolism. The initial and rate-limiting enzyme in the synthesis of these axnines is ornithine decarboxylase (ODC). According to animal experiments, its activity in tissues appears to be influenced by growth hormone (GH) activity. The induction of ODC activity results in an accumulation of SPD and a consequent increase in the molar ratio of SPD to SP (SPD/SP) in tissues (8).We determined SPD/SP as an indirect measure of the rate of polyamine synthesis in blood cells (9) in a group of children with short stature, with or without evidence of impaired GH secretion, to assess the role of GH in human polyamine metabolism. SUBJECTS AND METHODS

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Hormonal Regulation of Renal Ornithine Decarboxylase Activity in the Rat¹

Cited by 45 publications

References 0 publications

Compensatory Growth and Other Growth Responses of the Kidney

Compensatory Growth and Other Growth Responses of the Kidney

Serum and Urine Polyamines in Normal and in Short Children

Blood Cell Polyamines in Children with Short Stature in Reference to Growth Hormone Activity

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Hormonal Regulation of Renal Ornithine Decarboxylase Activity in the Rat1

Cited by 45 publications

References 0 publications

Compensatory Growth and Other Growth Responses of the Kidney

Compensatory Growth and Other Growth Responses of the Kidney

Serum and Urine Polyamines in Normal and in Short Children

Blood Cell Polyamines in Children with Short Stature in Reference to Growth Hormone Activity

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Product

Resources

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Hormonal Regulation of Renal Ornithine Decarboxylase Activity in the Rat¹