Hormonal changes induced by the pure antiandrogen flutamide in postmenopausal women with advanced breast cancer

Dehydroepiandrosterone Secretion in Healthy Older Men and Women: Effects of Testosterone and Growth Hormone Administration in Older Men

“…In gonadectomized men with advanced prostate cancer, androgen receptor blockade for 2 months significantly decreased basal and ACTH-stimulated serum DHEA and DHEAS concentrations (27). Similarly, in postmenopausal women, flutamide decreased serum DHEAS concentrations by 50% (28). Conversely, T administration in women increases ACTH-stimulated DHEA release (29).…”

Dehydroepiandrosterone Secretion in Healthy Older Men and Women: Effects of Testosterone and Growth Hormone Administration in Older Men

“…In gonadectomized men with advanced prostate cancer, androgen receptor blockade for 2 months significantly decreased basal and ACTH-stimulated serum DHEA and DHEAS concentrations (27). Similarly, in postmenopausal women, flutamide decreased serum DHEAS concentrations by 50% (28). Conversely, T administration in women increases ACTH-stimulated DHEA release (29).…”

Sex Differences in Adrenal Androgens

“…Studies using the relatively ''pure'' AR antagonist flutamide in postmenopausal women treated for advanced breast carcinoma showed a 50% decrease in circulating DHEAS. 97 Similarly, in gonadectomized men with prostatic carcinoma receiving both an antiandrogen and a gonadotropin-releasing hormone (GnRH) agonist, basal DHEA and DHEAS levels were reduced to 45 and 64% of control values after 60 days of treatment. 98 Similar decreases in DHEA and DHEAS were found in gonadectomized men receiving the same antiandrogen without GnRH agonist.…”

Flutamide

“…Decreases in circulating concentrations of the marker of adrenal androgen synthesis, dihydroepiandrosteronc sulphate and/or glucuronide, have been reported during long term flutamide administration in postmenopausal women (Secreto et al 1988) and castrated males (Brochu et al 1987).…”

Dehydroepiandrosterone Secretion in Healthy Older Men and Women: Effects of Testosterone and Growth Hormone Administration in Older Men

“…In gonadectomized men with advanced prostate cancer, androgen receptor blockade for 2 months significantly decreased basal and ACTH-stimulated serum DHEA and DHEAS concentrations (27). Similarly, in postmenopausal women, flutamide decreased serum DHEAS concentrations by 50% (28). Conversely, T administration in women increases ACTH-stimulated DHEA release (29).…”

Sex Differences in Adrenal Androgens

“…Studies using the relatively ''pure'' AR antagonist flutamide in postmenopausal women treated for advanced breast carcinoma showed a 50% decrease in circulating DHEAS. 97 Similarly, in gonadectomized men with prostatic carcinoma receiving both an antiandrogen and a gonadotropin-releasing hormone (GnRH) agonist, basal DHEA and DHEAS levels were reduced to 45 and 64% of control values after 60 days of treatment. 98 Similar decreases in DHEA and DHEAS were found in gonadectomized men receiving the same antiandrogen without GnRH agonist.…”

Flutamide

“…Decreases in circulating concentrations of the marker of adrenal androgen synthesis, dihydroepiandrosteronc sulphate and/or glucuronide, have been reported during long term flutamide administration in postmenopausal women (Secreto et al 1988) and castrated males (Brochu et al 1987).…”

Dehydroepiandrosterone Secretion in Healthy Older Men and Women: Effects of Testosterone and Growth Hormone Administration in Older Men

“…In gonadectomized men with advanced prostate cancer, androgen receptor blockade for 2 months significantly decreased basal and ACTH-stimulated serum DHEA and DHEAS concentrations (27). Similarly, in postmenopausal women, flutamide decreased serum DHEAS concentrations by 50% (28). Conversely, T administration in women increases ACTH-stimulated DHEA release (29).…”

Sex Differences in Adrenal Androgens

“…Studies using the relatively ''pure'' AR antagonist flutamide in postmenopausal women treated for advanced breast carcinoma showed a 50% decrease in circulating DHEAS. 97 Similarly, in gonadectomized men with prostatic carcinoma receiving both an antiandrogen and a gonadotropin-releasing hormone (GnRH) agonist, basal DHEA and DHEAS levels were reduced to 45 and 64% of control values after 60 days of treatment. 98 Similar decreases in DHEA and DHEAS were found in gonadectomized men receiving the same antiandrogen without GnRH agonist.…”

Flutamide

“…Decreases in circulating concentrations of the marker of adrenal androgen synthesis, dihydroepiandrosteronc sulphate and/or glucuronide, have been reported during long term flutamide administration in postmenopausal women (Secreto et al 1988) and castrated males (Brochu et al 1987).…”