Hormonal basis during pregnancy for the onset of maternal behavior in the rat

Rosenblatt, Jay S.; Mayer, Anne D.; Giordano, Anthony L.

doi:10.1016/0306-4530(88)90005-4

Cited by 204 publications

(126 citation statements)

References 88 publications

Supporting

Mentioning

118

Contrasting

Unclassified

Order By: Relevance

“…In rats, the last days of pregnancy are accompanied by changes in levels of hormones, e.g., progesterone, prolactin and oxytocin, which may stimulate maternal behaviors irrespective of any physical changes associated with parturition (for a review, see Rosenblatt et al, 1988;Numan and Insel, 2003). Indeed, artificially subjecting virgin female rats to hormonal changes characteristic of pregnancy stimulates maternal responsiveness (Bridges, 1984;Fleming, 1986).…”

Section: Discussionmentioning

confidence: 99%

Role of pregnancy and parturition in induction of maternal behavior in prairie voles (Microtus ochrogaster)

Hayes

Vries

2007

Hormones and Behavior

View full text Add to dashboard Cite

In prairie voles (Microtus ochrogaster), most virgin females are infanticidal. To determine the onset of maternal responsiveness, female prairie voles were tested for maternal behavior as virgins and at different times throughout pregnancy. Female voles that were infanticidal as virgins by and large remained infanticidal throughout pregnancy. In contrast, about 30% of voles that were maternal as virgins became infanticidal during pregnancy. To test whether events associated with parturition facilitate the onset of maternal behavior, females had their litters delivered by Caesarean section within a day of expected delivery or were allowed to give birth naturally with sham surgery occurring shortly before or after birth. Females that gave birth naturally were fully maternal and did not attack unrelated pups, but females subjected to artificial delivery remained infanticidal. This suggests that events closely related to parturition are crucial for full development of maternal behavior in female prairie voles.

show abstract

Section: Discussionmentioning

confidence: 99%

Role of pregnancy and parturition in induction of maternal behavior in prairie voles (Microtus ochrogaster)

Hayes

Vries

2007

Hormones and Behavior

View full text Add to dashboard Cite

show abstract

“…New dams display a variety of physical behaviors such as nest building, crouching over pups, and pup retrieval, that were not displayed prior to pregnancy and parturition (Rosenblatt et al, 1988). Exercise in female rats (several days of voluntary wheelrunning) significantly increases BDNF mRNA and protein in the hippocampus, particularly in the CA3 and DG (Berchtold et al, 2001;Berchtold et al, 2002;Cotman and Berchtold, 2002).…”

Section: Multiparity Significantly Elevated Bdnf Concentration In Ca1mentioning

confidence: 99%

Effects of multiparity on recognition memory, monoaminergic neurotransmitters, and brain-derived neurotrophic factor (BDNF)

Macbeth

Scharfman

MacLusky

et al. 2008

Hormones and Behavior

View full text Add to dashboard Cite

Recognition memory and anxiety were examined in nulliparous (NP: 0 litters) and multiparous (MP: 5-6 litters) middle-aged female rats (12 months old) to assess possible enduring effects of multiparity at least 3 months after last litter was weaned. MP females performed significantly better than NP females on the non-spatial memory task, object recognition, and the spatial memory task, object placement. Anxiety as measured on the elevated plus maze did not differ between groups. Monoaminergic activity and levels were measured in prefrontal cortex, CA1 hippocampus, CA3 hippocampus, and olfactory bulb (OB). NP and MP females differed in monoamine concentrations in the OB only, with MP females having significantly greater concentrations of dopamine and metabolite DOPAC, norepinephrine and metabolite MHPG, and the serotonin metabolite 5-HIAA, as compared to NP females. These results indicate a long-term change in OB neurochemistry as a result of multiparity. Brain-derived neurotrophic factor (BDNF) was also measured in hippocampus (CA1, CA3, dentate gyrus), and septum. MP females had higher BDNF levels in both CA1 and septum; as these regions are implicated in memory performance, elevated BDNF may underlie the observed memory task differences. Thus, MP females (experiencing multiple bouts of pregnancy, birth, and pup rearing during the first year of life) displayed enhanced memory task performance, but equal anxiety responses, as compared to NP females. These results are consistent with previous studies showing long-term changes in behavioral function in MP, as compared to NP, rats, and suggest that alterations in monoamines and a neurotrophin, BDNF, may contribute to the observed behavioral changes.

show abstract

“…Our present results show that uterine distension induced expression of HspB1 mRNA and pSer 15 HspB1 protein levels at days 19 and 23, demonstrating the important role of distension or mechanical stress on the regulation of expression, regardless of the day in late pregnancy. However, the increased expression in the gravid horns was observed when circulating levels of progesterone and 17␤-estradiol were reported to be elevated in the rat at days 19 and 23, respectively (37). As a result, it was still possible that these steroids, as well as other contributions from the fetoplacental unit, could contribute to the observed increases in HspB1 expression during late pregnancy.…”

Section: Uterine Distension Induces Expression Of Hspb1 Mrna and Psermentioning

confidence: 78%

Distension of the uterus induces HspB1 expression in rat uterine smooth muscle

White

MacPhee

2011

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

Hormonal basis during pregnancy for the onset of maternal behavior in the rat

Cited by 204 publications

References 88 publications

Role of pregnancy and parturition in induction of maternal behavior in prairie voles (Microtus ochrogaster)

Role of pregnancy and parturition in induction of maternal behavior in prairie voles (Microtus ochrogaster)

Effects of multiparity on recognition memory, monoaminergic neurotransmitters, and brain-derived neurotrophic factor (BDNF)

Distension of the uterus induces HspB1 expression in rat uterine smooth muscle

Contact Info

Product

Resources

About