Hopkins syndrome: T2-weighted high intensity of anterior horn on spinal MR imaging

Arita, Jiro; Nakae, Yoichiro; Miyata, Hiroshi; Maekawa, Kihei

doi:10.1016/0887-8994(95)00181-e

Cited by 22 publications

(10 citation statements)

References 14 publications

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“…Also, these lesions have been described with Hopkins syndrome, a poliomyelitis-like illness manifesting flaccid paralysis of an extremity in the recovery stage after an asthmatic attack. A patient with Hopkins syndrome had T2 hyperintensity of the left anterior horn in the cervical spinal cord [21].…”

Section: Enterovirusesmentioning

confidence: 99%

Imaging of Topographic Viral CNS Infections

Rumboldt

2008

Neuroimaging Clinics of North America

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Section: Enterovirusesmentioning

confidence: 99%

Imaging of Topographic Viral CNS Infections

Rumboldt

2008

Neuroimaging Clinics of North America

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“…Onset is over a day or two, with few cases over a number of hours. The few reports of neuroimaging in Hopkins’s syndrome suggest consistently abnormal findings in the anterior part of the spinal cord on T 2 weighted sequences,16 17 as is seen in poliomyelitis 10. Electrophysiology in Hopkins’s syndrome demonstrates an abnormality consistent with anterior horn cell damage.…”

Section: Discussionmentioning

confidence: 97%

Rapid onset transverse myelitis in adolescence: implications for pathogenesis and prognosis

Wilmshurst

Walker

Pohl

1999

Archives of Disease in Childhood

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Five adolescents with transverse myelitis were reviewed. All presented with a rapid onset paralysis of the lower limbs and impairment of bladder control. The maximum disability developed between 10 minutes and six hours. There was no history of trauma, asthma, or prodromal illness. Investigations failed to demonstrate a vascular cause. Extensive spinal cord abnormalities were observed on magnetic resonance imaging. Electrophysiological investigations, performed in four cases, were all consistent with anterior horn cell damage. In all five adolescents there was poor recovery. The underlying pathogenesis of this rapid onset condition remains a subject of debate. Similarities with both transverse myelitis and fibrocartilaginous emboli are evident, widening the spectrum of conditions within the transverse myelitis umbrella. These observations suggest that in rapid onset "transverse myelitis" the combination of extensive hyperintensity on spinal cord neuroimaging with electrophysiological evidence of anterior horn cell involvement might have adverse prognostic significance.

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“…O ataque de asma, junto com o uso de corticóides, pode servir como gatilho para que vírus neurotrópi-cos invadam o corno anterior da medula, causando lesão em metâmeros específicos 2,8 . Kyllerman descreveu um caso de SH em menino de sete anos, no qual foi isolado Herpes vírus tipo I no LCR, durante a fase aguda da doença 9 .…”

Section: Discussionunclassified

Síndrome de Hopkins no diagnóstico diferencial das paralisias flácidas na infância: aspectos clínicos e neurofisiológicos. Relato de caso

Nora

Gomes

Ammar

et al. 2003

Arq. Neuro-Psiquiatr.

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INTRODUÇÃO: A síndrome de Hopkins (SH) é caracterizada por monoplegia ou diplegia, decorrente de lesão no corno anterior da medula, que se segue a um ataque agudo de asma, ocorre geralmente em crianças e sua etiologia ainda não está definida. Há 34 casos descritos no mundo, sendo este o primeiro relato na América do Sul e durante o primeiro ano de vida. CASO: Criança internada aos 4 meses de idade com quadro de sibilância e insuficiência respiratória. Cerca de 3 dias após melhora do quadro respiratório, observou-se perda de força nos membros inferiores. Teve alta hospitalar com regressão do quadro respiratório mantendo a paraparesia. Reinternada aos 9 meses de idade por novo quadro de broncoespasmo, demonstrando paralisia flácida assimétrica (E>D) e atrofia nos membros inferiores. EXAME NEUROLÓGICO: força e reflexos miotáticos normais nos membros superiores, arreflexia miotática nos membros inferiores e sensibilidade preservada. Exames de líquor, ressonância magnética de coluna lombossacra e potencial evocado somatossensitivo dos membros inferiores: normais. BIÓPSIA MUSCULAR: Grupamento de fibras. A eletroneuromiografia demonstrou sinais de lesão do neurônio motor do corno anterior da medula nos metâmeros lombossacros. CONCLUSÃO: A Síndrome de Hopkins, apesar de rara, deve ser lembrada no diagnóstico diferencial de paralisias flácidas, quando houver concomitância com asma.

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Hopkins syndrome: T2-weighted high intensity of anterior horn on spinal MR imaging

Cited by 22 publications

References 14 publications

Imaging of Topographic Viral CNS Infections

Imaging of Topographic Viral CNS Infections

Rapid onset transverse myelitis in adolescence: implications for pathogenesis and prognosis

Síndrome de Hopkins no diagnóstico diferencial das paralisias flácidas na infância: aspectos clínicos e neurofisiológicos. Relato de caso

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