Honey protects against chronic unpredictable mild stress induced- intestinal barrier disintegration and hepatic inflammation

Mehranfard, Nasrin; Yazdi, Azadeh; Sardooi, Asiye Rafiee; Shakerin, Zeinab; Ghasemi, Maedeh

doi:10.1007/s11033-020-05888-4

Cited by 9 publications

(5 citation statements)

References 46 publications

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“…Exposure to CUMS showed enhanced intestinal protein expression of NF-κB, a transcription factor that regulates a variety of biological processes such as inflammation and immune response. We observed that CUMS-induced activation of the NF-κB was associated with increased production of inflammatory cytokines [41]. Along with the tissue inflammation, an increase in acute phase inflammatory mediators, such as IL-6, TNF-α, and CRP in blood plasma, shows an inflammatory response in the circulation.…”

Section: Discussionmentioning

confidence: 82%

Combined Supplementation of Clostridium butyricum and Bifidobacterium infantis Diminishes Chronic Unpredictable Mild Stress-Induced Intestinal Alterations via Activation of Nrf-2 Signaling Pathway in Rats

Fatima

Altwaijry

Abulmeaty

et al. 2023

IJMS

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Exposure to long-term chronic unpredictable mild stress (CUMS) can cause redox imbalance and inflammation, which may affect the integrity of the gut barrier. The present study was conducted to investigate the effects of a probiotics bacterium mixture, including Clostridium butyricum (C. butyricum) and Bifidobacterium infantis (B. infantis), on the intestinal homeostasis in rats exposed to multiple low-intensity stressors for 28 days. The mechanism of CUMS-induced altered intestinal homeostasis was evaluated by focusing on the nuclear factor-E2-related factor-2 (Nrf-2) pathway. In contrast to the CUMS group, probiotic mixture supplementation significantly (p < 0.01) reversed the stress-induced elevated corticosterone level, protein and lipid oxidation, and increased enzymatic and non-enzymatic antioxidant levels, as well as upregulated Nrf-2/HO-1 pathway. Probiotics supplementation further significantly (p < 0.01) decreased the CUMS-induced inflammation, altered T-lymphocyte levels, and suppressed the protein expression of nuclear factor kappa B (NF-κB) in rat intestines. Improvement in histological changes and intestinal barrier integrity further validate the beneficial effects of probiotic mixtures on CUMS-induced altered intestinal morphology. In conclusion, our results suggest that the combination of C. butyricum and B. infantis significantly attenuated CUMS-induced oxidative stress, inflammation, and T-lymphocyte modulation by upregulating Nrf-2/HO-1 signaling and inhibiting NF-κB expression in rat intestine.

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Section: Discussionmentioning

confidence: 82%

Combined Supplementation of Clostridium butyricum and Bifidobacterium infantis Diminishes Chronic Unpredictable Mild Stress-Induced Intestinal Alterations via Activation of Nrf-2 Signaling Pathway in Rats

Fatima

Altwaijry

Abulmeaty

et al. 2023

IJMS

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“…Zinc has antioxidant proprieties [ 17 ] that help to reduce the concentration of reacting oxidative species (ROS); ROS contribute to the increase of inflammation and tissues damage [ 18 ] and their reduction is helpful to rapidly solve infection and inflammation. Honey [ 19 ] and tyndallized Lactobacillus [ 19 ] improve the systemic immune response acting on the gut flora and preserving the intestinal balance.…”

Section: Discussionmentioning

confidence: 99%

Single-Center-Single-Blinded Clinical Trial to Evaluate the Efficacy of a Nutraceutical Containing Boswellia Serrata, Bromelain, Zinc, Magnesium, Honey, Tyndallized Lactobacillus Acidophilus and Casei to Fight Upper Respiratory Tract Infection and Otitis Media

Volpe¹,

Luca

Lucia³

et al. 2022

Healthcare

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Some nutraceuticals have been studied as supportive treatment for fighting upper respiratory tract infection and middle ear disease. Our study aims at evaluating the effect of a specific oral supplementation in the treatment of pediatric otits media. The subjects were randomly assigned by the physician (single-blinded study) to one of three groups: Control Group (CG), Treatment Group 1 (TG1), or Treatment Group 2 (TG2). Both TG were treated with Flogostop Duo (for 20 days—TG1 or 30 days—TG2) in combination with the standard treatment, while CG underwent standard treatment only. The standard treatment was nasal aerosol with Fluticasone and Mucolytic, and nasal washing with hypertonic solution. All patients were analyzed by otoscopy, impedance, fibroscopy, and pure auditory test at the baseline (T0), after 20 days (T1) and 35 days (T2). 120 children were included in the study, 40 in the CG, 40 in the TG1, and 40 in the TG2. Both TG1 and TG2 presented statistically significant differences with respect to controls in otoscopy, impedance, fibroscopy, and PTA at T2. The otoscopy improved at T2 with statistically significant value only in TG2. The impedance and fibroscopy improved at T1 both in TG1 and TG2 compared to CG. A statistically significant improvement was observed in TG2 at T2 in comparison to both CG and TG1. Statistically significant differences were observed in PTA at T2 only compared with controls. This study confirmed the efficacy of nutraceutical as supporting therapy in the upper respiratory tract infection in children. In particular, the supplement containing Boswellia serrata and Bromelain, which are molecules with strong anti-inflammatory and pain-control capacities, could add the benefit without the adverse effects which are related to NSAID use.

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“…Pharmacologic molecules provide an undeniable therapeutic effect, but their use is a double-edged-sword due their toxicity; hence, the search for effective and "sustainable" interventions that have been tested in experimental models has been propelled. The potential therapeutic effects of non-pharmacologic molecules, including probiotics [91], amino acids [95], and natural antioxidants, against gut barrier disturbances under stress conditions have been tested [126,127]. However, clinical studies are necessary to demonstrate the efficacy of probiotics, honey, and herbal preparations in intestinal inflammatory diseases in humans.…”

Section: Perspectivesmentioning

confidence: 99%

“…Honey provides benefits in terms of alleviating stress effects on the gut barrier, as documented in mice who experienced chronic unpredictable mild stress. The findings indicated that, under stress conditions, honey increased the TJ complex and hepatic total antioxidant capacity (TAC) protection associated with the inhibition via the NFκB signal of oxidative markers like malondialdehyde, nitric oxide, nuclear factor (erythroid-derived 2)-like 2 (NrF2), and TNFα [127].…”

Section: Perspectivesmentioning

confidence: 99%

Role of Stress on Driving the Intestinal Paracellular Permeability

Molotla-Torres,

Guzmán-Mejía,

Godínez-Victoria

et al. 2023

CIMB

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The gut epithelium is a polarized monolayer that exhibits apical and basolateral membrane surfaces. Monolayer cell components are joined side by side via protein complexes known as tight junction proteins (TJPs), expressed at the most apical extreme of the basolateral membrane. The gut epithelium is a physical barrier that determinates intestinal permeability, referred to as the measurement of the transit of molecules from the intestinal lumen to the bloodstream or, conversely, from the blood to the gut lumen. TJPs play a role in the control of intestinal permeability that can be disrupted by stress through signal pathways triggered by the ligation of receptors with stress hormones like glucocorticoids. Preclinical studies conducted under in vitro and/or in vivo conditions have addressed underlying mechanisms that account for the impact of stress on gut permeability. These mechanisms may provide insights for novel therapeutic interventions in diseases in which stress is a risk factor, like irritable bowel syndrome. The focus of this study was to review, in an integrative context, the neuroendocrine effects of stress, with special emphasis on TJPs along with intestinal permeability.

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Honey protects against chronic unpredictable mild stress induced- intestinal barrier disintegration and hepatic inflammation

Cited by 9 publications

References 46 publications

Combined Supplementation of Clostridium butyricum and Bifidobacterium infantis Diminishes Chronic Unpredictable Mild Stress-Induced Intestinal Alterations via Activation of Nrf-2 Signaling Pathway in Rats

Combined Supplementation of Clostridium butyricum and Bifidobacterium infantis Diminishes Chronic Unpredictable Mild Stress-Induced Intestinal Alterations via Activation of Nrf-2 Signaling Pathway in Rats

Single-Center-Single-Blinded Clinical Trial to Evaluate the Efficacy of a Nutraceutical Containing Boswellia Serrata, Bromelain, Zinc, Magnesium, Honey, Tyndallized Lactobacillus Acidophilus and Casei to Fight Upper Respiratory Tract Infection and Otitis Media

Role of Stress on Driving the Intestinal Paracellular Permeability

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