Homogeneity in mitochondrial DNA control region sequences in Swedish subpopulations

Tillmar, Andreas; Coble, Michael D.; Wallerström, Thomas; Holmlund, Gunilla

doi:10.1007/s00414-009-0354-7

Cited by 18 publications

(27 citation statements)

References 29 publications

(38 reference statements)

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“…By examining the extent of damage in the ancient sequences, we were able to discriminate between genuine ancient DNA sequences and more recent contamination. Starting with 80 skeletal samples, we recovered authentic mtDNA sequences from 45 Norwegians from the Late Iron Age, contemporary with the Viking expansion. While it is important to remember that the individuals did not necessarily live at the same time, and could have been separated by several centuries, this is the single largest ancient DNA sample-set representing the past population of Norway.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial DNA variation in the Viking age population of Norway

Krzewińska

Bjørnstad

Skoglund

et al. 2015

Phil. Trans. R. Soc. B

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The medieval Norsemen or Vikings had an important biological and cultural impact on many parts of Europe through raids, colonization and trade, from about AD 793 to 1066. To help understand the genetic affinities of the ancient Norsemen, and their genetic contribution to the gene pool of other Europeans, we analysed DNA markers in Late Iron Age skeletal remains from Norway. DNA was extracted from 80 individuals, and mitochondrial DNA polymorphisms were detected by next-generation sequencing. The sequences of 45 ancient Norwegians were verified as genuine through the identification of damage patterns characteristic of ancient DNA. The ancient Norwegians were genetically similar to previously analysed ancient Icelanders, and to present-day Shetland and Orkney Islanders, Norwegians, Swedes, Scots, English, German and French. The Viking Age population had higher frequencies of K*, U*, V* and I* haplogroups than their modern counterparts, but a lower proportion of T* and H* haplogroups. Three individuals carried haplotypes that are rare in Norway today (U5b1b1, Hg A* and an uncommon variant of H*). Our combined analyses indicate that Norse women were important agents in the overseas expansion and settlement of the Vikings, and that women from the Orkneys and Western Isles contributed to the colonization of Iceland.

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Section: Discussionmentioning

confidence: 99%

Mitochondrial DNA variation in the Viking age population of Norway

Krzewińska

Bjørnstad

Skoglund

et al. 2015

Phil. Trans. R. Soc. B

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“…On the other hand, U5a2a was present in a Mesolithic population from Western Europe 7000 years ago, around its first appearance in Central Europe, 3 even though nowadays U5a2a is only found at very low frequencies in central and northern Europe. [37][38][39] Prehistoric European genetic context The contextualisation of the human remains of the Cave of Santimamiñe into the European prehistory is not a simple issue due to the different antiquity of these samples. Therefore, four individuals of Santimamiñe, which dated into a relatively narrow period of time, ranging from Chalcolithic to Bronze Age, were grouped together (SntBrCh) to study their phylogenetic link with other prehistoric European remains (Supplementary Dataset S3).…”

Section: Phylogenetic Historymentioning

confidence: 99%

Ancient mitochondrial lineages support the prehistoric maternal root of Basques in Northern Iberian Peninsula

et al. 2017

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The Basque population inhabits the Franco-Cantabrian region in southwest Europe where Palaeolithic human groups took refuge during the Last Glacial Maximum. Basques have been an isolated population, largely considered as one of the most ancient European populations and it is possible that they maintained some pre-Neolithic genetic characteristics. This work shows the results of mitochondrial DNA analysis of seven ancient human remains from the Cave of Santimamiñe in the Basque Country dated from Mesolithic to the Late Roman period. In addition, we compared these data with those obtained from a modern sample of Basque population, 158 individuals that nowadays inhabits next to the cave. The results support the hypothesis that Iberians might have been less affected by the Neolithic mitochondrial lineages carried from the Near East than populations of Central Europe and revealed the unexpected presence of prehistoric maternal lineages such as U5a2a and U3a in the Basque region. Comparison between ancient and current population samples upholds the hypothesis of continuity of the maternal lineages in the area of the Franco-Cantabrian region.

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“…On the other hand, the findings of a sizeable number of recent mtDNA studies in worldwide populations are indicative that the analysis of the entire mtDNA control region can yield higher values of the power of discrimination [8][9][10][11][12][13][14], which confers additional interest to mitochondrial genome from a forensic perspective. The present study is intended to characterize the diversity of the matrilineal lineages of the current population of Santa Catarina (Brazil) by analyzing the entire mitochondrial DNA control region.…”

Section: Introductionmentioning

confidence: 96%

Mitochondrial DNA diversity in a population from Santa Catarina (Brazil): predominance of the European input

et al. 2010

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The state of Santa Catarina (Brazil) is known to have represented a cultural crossroads in South America due to several historic migrations mainly from Europe and Africa. We set out to scrutinize whether the genetic imprint of these migrations could be traced through analysis of the matrilineal gene pool of the Catarinenses. The entire control region of the mitochondrial DNA was studied in 80 healthy and maternally unrelated individuals. The analysis of haplogroup distribution revealed that this population is extremely heterogeneous, showing the coexistence of matrilineal lineages with three different phylogeographic origins. European lineages are the most frequent due mainly to the impact of relatively recent migratory waves from Europe. In spite of this, Native American lineages and African lineages incorporated with the slave trade are also present in noticeable proportions. The strikingly high variability generated by intense gene flow is mirrored in a high sequence diversity (0.9930) and power of discrimination (0.9806). Thus, analysis of the entire mitochondrial DNA control region emerges as a valuable tool for forensic genetic purposes in this highly admixed population, an attribute common to several present-day Latin American populations.

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Homogeneity in mitochondrial DNA control region sequences in Swedish subpopulations

Cited by 18 publications

References 29 publications

Mitochondrial DNA variation in the Viking age population of Norway

Mitochondrial DNA variation in the Viking age population of Norway

Ancient mitochondrial lineages support the prehistoric maternal root of Basques in Northern Iberian Peninsula

Mitochondrial DNA diversity in a population from Santa Catarina (Brazil): predominance of the European input

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