Homocysteine, folic acid and vitamin B12 levels in maternal and umbilical cord plasma and homocysteine levels in placenta in pregnant women with pre-eclampsia

Acılmıs, Yurdanur Gurcay; Dıkensoy, Ebru; Kutlar, Ali Irfan; Balat, Özcan; Cebesoy, Fatma Bahar; Öztürk, Ebru; Çiçek, Hülya; Pençe, Sadrettin

doi:10.1111/j.1447-0756.2010.01317.x

Cited by 57 publications

(50 citation statements)

References 21 publications

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“…The authors conclude that the levels of homocysteine are significantly higher in the group of women with severe preeclampsia as compared with the groups of women with mild preeclampsia and those with normal pregnancy, suggesting that the increased homocysteine levels may be associated with the severity of preeclampsia. They also consider that elevated homocysteine levels do not appear to be accompanied by folic acid and vitamin B12 deficiency (24). A similar homocysteine pattern was also observed in our study.…”

Section: Discussionsupporting

confidence: 77%

“…absence of biological plausibility; therefore, they consider that the association of hyperhomocysteinemia and preeclampsia cannot be explained by the current literature data (23). In contrast to the study by Mignini et al (23), a more recent report by Acilmis et al (24) offers an explanation of the obscurities related to hyperhomocysteinemia and pregnancy by differentiating severe and mild preeclampsia. They monitored the levels of homocysteine, folic acid and vitamin B12 in three groups of pregnant women, i.e.…”

Section: Discussioncontrasting

confidence: 50%

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Maternal and umbilical homocysteine in preeclampsia

Bobić

Habek

2016

Period Biol

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Background and purpose: Were to assess the association between homocysteine levels and development of preeclampsia, to determine homocysteine levels in fetal circulation, to differentiate homocysteine levels in mild and severe preeclampsia and to compare homocysteine levels in pregnant women with preeclampsia with homocysteine levels measured in the same group of women six months after delivery. Material and methods: IntroductIon Since the 1990s, homocysteine has been associated with disorders of the fetomaternal unit (1). Studies on recurrent abortions also found clear association between elevated homocysteine levels and the risk of abortion (2,3). Later on, Vollset et al. (4) found the levels of homocysteine to be associated with the prevalence of preeclampsia, preterm delivery, low birth weight, intrauterine growth restriction (IUGR), stillbirth, congenital malformations and abruptio placentae. The association of mild hyperhomocysteinemia with cardiovascular disease and related mortality was demonstrated in a number of studies (5-11).Hyperhomocysteinemia alters vascular morphology, stimulates inflammation, activates endothelium and blood clotting cascade, and inhibits fibrinolysis. Hyperhomocysteinemia results in the loss of endothelial antithrombin function and induction of a procoagulant setting (9,12). The pathogenetic action of homocysteine also includes interference with the nitric oxide (NO) system (homocysteine reduces NO bioavailability by interfering with its synthesis), activation of transcrip- (13,14). The aims of the study were to assess the association between elevated homocysteine levels and development of preeclampsia; to determine homocysteine levels in fetal circulation; to differentiate homocysteine levels in mild and severe preeclampsia; and to compare homocysteine levels in pregnant women with preeclampsia with homocysteine levels measured in the same group of women six months after delivery. methodsThe study included 55 pregnant women with verified milde preeclampsia (blood pressure measured on two occasions at least 4 h apart ≥140/90 mm Hg after 20 th week of gestation, and positive proteinuria) and severe preeclampsia (blood pressure ≥160/110 mm Hg, proteinuria ≥++). Control group consisted of 50 healthy pregnant women, as approved by the Ethics Committee of the Osijek University Hospital. All pregnant women are taking folate supplements and vitamins, including B6 and B12 during pregnancy and puerperium (Elevit®, Bayer, Germany). In both preeclampsia and control group, homocysteine levels were measured after at least 12-h fasting. Umbilical blood homocysteine levels were determined in the same groups of women after delivery, during third stage. In the group of women with preeclampsia, blood homocysteine was also determined six months after delivery. Homocysteine levels were determined by the FPIA (fluorescence polarization immunoassay) technology on an AxSYM device (Abbott Laboratories) using reagents of the same manufacturer . According to Khong and Hague (15), hyperhomocyst...

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Section: Discussionsupporting

confidence: 77%

Section: Discussioncontrasting

confidence: 50%

Maternal and umbilical homocysteine in preeclampsia

Bobić

Habek

2016

Period Biol

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“…Blood concentrations of homocysteine are determined by various dietary factors, including folic acid and vitamin B 12 , by alteration in physiology, such as renal impairment, and by variation in the activity of enzymes in the various pathways as a result of genetic polymorphisms, some of which are commonly found in the population. Hyperhomocysteinemia has been associated with vascular disease, although whether it is cause or effect is still a matter of debate.…”

Section: Discussionmentioning

confidence: 99%

“…11 Acilmis et al concluded that maternal and fetal serum homocysteine levels were found to be significantly higher in severe pre-eclampsia group compared to mild pre-eclampsia and control groups suggesting that elevated serum levels of homocysteine might be associated with severity of pre-eclampsia. 12 It has been hypothesized that in vitro, homocysteine enhances spontaneous contractions of myometrium. Applying the same it has been postulated that high homocysteine in early pregnancy leads to preterm labour.…”

Section: Discussionmentioning

confidence: 99%

Correlation of serum homocysteine levels and pregnancy outcome: the dilemma continues

Jaiswal

Agrawal

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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“…For example, in several studies, women with preeclampsia had significantly higher homocysteine concentrations than normotensive pregnant women; however, no significant differences were found in serum or plasma vitamin B-12 concentrations between groups (86-88). Among patients with severe preeclampsia in Greece (blood pressure: $170/110 mm Hg) and Turkey (blood pressure: $160/110 mm Hg), only homocysteine concentrations were significantly higher, compared with normotensive pregnant women (P < 0.001 and P < 0.05, respectively) (86,87). In addition, in a cohort Gestational diabetes.…”

Section: Literature Reviewmentioning

confidence: 99%

Vitamin B-12 and Perinatal Health

Finkelstein

Layden

Stover

2015

Advances in Nutrition

133

104

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Vitamin B-12 deficiency (<148 pmol/L) is associated with adverse maternal and neonatal outcomes, including developmental anomalies, spontaneous abortions, preeclampsia, and low birth weight (<2500 g). The importance of adequate vitamin B-12 status periconceptionally and during pregnancy cannot be overemphasized, given its fundamental role in neural myelination, brain development, and growth. Infants born to vitamin B-12-deficient women may be at increased risk of neural tube closure defects, and maternal vitamin B-12 insufficiency (<200 pmol/L) can impair infant growth, psychomotor function, and brain development, which may be irreversible. However, the underlying causal mechanisms are unknown. This review was conducted to examine the evidence that links maternal vitamin B-12 status and perinatal outcomes. Despite the high prevalence of vitamin B-12 deficiency and associated risk of pregnancy complications, few prospective studies and, to our knowledge, only 1 randomized trial have examined the effects of vitamin B-12 supplementation during pregnancy. The role of vitamin B-12 in the etiology of adverse perinatal outcomes needs to be elucidated to inform public health interventions. Adv Nutr 2015;6:552-63.

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Homocysteine, folic acid and vitamin B12 levels in maternal and umbilical cord plasma and homocysteine levels in placenta in pregnant women with pre-eclampsia

Cited by 57 publications

References 21 publications

Maternal and umbilical homocysteine in preeclampsia

Maternal and umbilical homocysteine in preeclampsia

Correlation of serum homocysteine levels and pregnancy outcome: the dilemma continues

Vitamin B-12 and Perinatal Health

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