Holothurians antifungal and antibacterial activity to human pathogens in the Persian Gulf

Mashjoor, Sakineh; Yousefzadi, Morteza

doi:10.1016/j.mycmed.2016.08.008

Cited by 23 publications

(17 citation statements)

References 22 publications

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“…However, in this study, H atra exerted no effect on any of the bacterial strains tested. Similar results have been reported by others 39 for Candida albicans, Pseudomonas aeruginosa, and K pneumoniae , but the extract has been reported to have an antibacterial effect against Staphylococcus epidermidis . The difference in results may be due the high fat content of the extract or a difference in extraction methods.…”

Section: Discussionsupporting

confidence: 90%

Susceptibility Assessment of Multidrug Resistant Bacteria to Natural Products

et al. 2020

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Objective: The aim of this study was to examine the effect of some natural compounds against multidrug-resistant bacteria. Methods: Forty-three bacterial strains were collected. Disc diffusion and minimum inhibitory concentration (MIC) tests were carried out for natural compounds including quercetin, Acacia nilotica, Syzygium aromaticum, and Holothuria atra. Scanning electron microscope analysis and bacterial DNA apoptosis assays were performed. Results: Staphylococcus aureus strains were resistant to imipenim, ampicillin, and penicillin. Most Escherichia coli strains were resistant to amoxicillin, clavulanat, and ampicillin. Finally, tigecycline was effective with Klebsiella pneumoniae and was resistant to all antibiotics. Only S aromaticum had an antibacterial effect on K pneumoniae. Most S aureus strains were sensitive to S aromaticum, A nilotica, and quercetin. All examined natural extracts had no effect on E coli. Holothuria atra had no effect on any of the strains tested. Minimum inhibitory concentration and minimum bactericidal concentration values for examined plants against S aureus were 6.25 to 12, 1.6 to 3.2, and 9.12 to 18.24 mg/mL, respectively. Syzygium aromaticum was active against K pneumoniae with an MIC of 12.5 mg/mL. Scanning electron microscope analysis performed after 24 and 48 hours of incubation showed bacterial strains with distorted shapes and severe cell wall damage. Syzygium aromaticum, quercetin, and A nilotica showed clear fragmentations of S aureus DNA. Conclusions: Current findings confirmed the beneficial effect of using natural products such as clove (S aromaticum), quercetin, and A nilotica as a promising therapy to overcome multidrug resistant bacteria.

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Section: Discussionsupporting

confidence: 90%

Susceptibility Assessment of Multidrug Resistant Bacteria to Natural Products

et al. 2020

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“…Saponins are phytochemicals, which can be found most in peas, soybeans and herbs. In this review, multiple studies reveal the potential antifungal activities against C. albicans in the presence of saponins [40,41,75,79,80,91,104,110,125,127]. However, in this review, the detailed mechanisms of action of saponins have not been well investigated.…”

Section: Active Compoundsmentioning

confidence: 99%

Herbal Extracts with Antifungal Activity against Candida albicans: A Systematic Review

Hsu

Sheth

Veses

2021

MRMC

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Background: In the era of antimicrobial resistance, fungal pathogens are not an exception. Several strategies, including antimicrobial stewardship programs and high throughput screening of new drugs are being implemented. Several recent studies have demonstrated effectiveness of plant compounds with antifungal activity. Objective: In this systematic review we examine the use of natural compounds as a possible avenue to fight fungal infections produced by Candida albicans, the most common human fungal pathogen. Method: Electronic literature searches were conducted through PubMed/MEDLINE, Cochrane, and Science Direct limited to the 5 years. A total of 131 articles were included with 186 plants extracts evaluated. Results: Although the majority of the natural extracts exhibited antifungal activities against C. albicans (both in vivo and in vitro), the strongest antifungal activity was obtained from Lawsonia inermis, Pelargonium graveolens, Camellia sinensis, Mentha piperita, and Citrus latifolia. Conclusion: The main components with proven antifungal activities were phenolic compounds such as gallic acid, thymol, and flavonoids (specially catechin), polyphenols such as tannins, terpenoids and saponins. The incorporation of nanotechnology enhances greatly the antifungal properties of these natural compounds. Further research is needed to fully characterize the composition of all herbal extracts with antifungal activity as well as the mechanisms of action of the active compounds.

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“…Holothurians have been attracting increasing interest for their high content of secondary metabolites with manifold potential applications, especially in the pharmaceutical field [2]. The biological potential of sea cucumbers ranges from antitumor to antimicrobial, anti-inflammatory and antiviral activities [3,4,5,6,7,8]. Moreover, it has been reported that sea cucumbers extracts may act as anticoagulant agents and inhibitors of hyperlipidemia [9,10].…”

Section: Introductionmentioning

confidence: 99%

Molecular Networking-Based Analysis of Cytotoxic Saponins from Sea Cucumber Holothuria atra

et al. 2019

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The saponin composition of a specimen of black sea cucumber, Holothuria atra collected in the Persian Gulf was studied by a combined approach including LC-MS/MS, Molecular Networking, pure compound isolation, and NMR spectroscopy. The saponin composition of Holothuria atra turned out to be more complex than previously reported. The most abundant saponins in the extract (1–4) were isolated and characterized by 1D- and 2D-NMR experiments. Compound 1 was identified as a new triterpene glycoside saponin, holothurin A5. The side chain of the new saponin 1, unprecedented among triterpene glycosides, is characterized by an electrophilic enone function, which can undergo slow water or methanol addition under neutral conditions. The cytotoxic activity of compounds 1–4, evaluated on the human cervix carcinoma HeLa cell line, was remarkable, with IC50 values ranging from 1.2 to 2.5 µg/mL.

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Holothurians antifungal and antibacterial activity to human pathogens in the Persian Gulf

Cited by 23 publications

References 22 publications

Susceptibility Assessment of Multidrug Resistant Bacteria to Natural Products

Susceptibility Assessment of Multidrug Resistant Bacteria to Natural Products

Herbal Extracts with Antifungal Activity against Candida albicans: A Systematic Review

Molecular Networking-Based Analysis of Cytotoxic Saponins from Sea Cucumber Holothuria atra

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