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Cited by 51 publications
(17 citation statements)
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References 30 publications
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“…It is reasonable that a dense cell population with a highly viable cell number could provide more integrin to elicit shrinkage force of collagen fiber and thus facilitate gel contraction. Normally, gel contraction was observed for a collagen concentration range of 0.5-2.0 mg/mL (Liu et al 1998;Wu et al 1996). Thus, it appeared unexpected that no significant contraction occurred at a high collagen concentration of 4.50 mg/mL.…”
Section: Discussionmentioning
confidence: 97%
See 1 more Smart Citation
“…It is reasonable that a dense cell population with a highly viable cell number could provide more integrin to elicit shrinkage force of collagen fiber and thus facilitate gel contraction. Normally, gel contraction was observed for a collagen concentration range of 0.5-2.0 mg/mL (Liu et al 1998;Wu et al 1996). Thus, it appeared unexpected that no significant contraction occurred at a high collagen concentration of 4.50 mg/mL.…”
Section: Discussionmentioning
confidence: 97%
“…Previously, the active interaction between collagen and the embedded cells was assumed to enhance cellular functions (Wu et al 1996;Yamada et al 2001) and, furthermore, high cell density culture was highly suggested to enhance cell viability and hepatocellular functions such as albumin and urea secretion and detoxification (Dvir-Ginzberg et al 2003). Nevertheless, in this paper, the non-correlation between gel contraction and cell activity was unexpectedly concluded as a result of the fact that cell viability as well as liver-specific functions per viable cell were lower in the gel entrapment cultures at higher cell densities regardless of the more severe gel contraction observed.…”
Section: Discussionmentioning
confidence: 99%
“…[59][60][61][62][63][64][65][66][67] Primary hepatocytes have been cultured using a number of techniques that aim to minimize the loss of liver-specific functions and maximize cell viability. Common approaches include 3D cultures and modification of culture media.…”
Section: Liver Tissue Modelsmentioning
confidence: 99%
“…This bioreactor was proposed as an attractive model for in vitro drug screenings by the authors [103] but has never been seen in further application. Another case was the well maintained phase I and II metabolic enzymes in BAL cultured with hepatocytes of spheroids [104,105] or disperse in gel entrapment [106]. The configuration of gel entrapped hepatocytes in BAL is shown in Fig.…”
Section: Membrane-based Cell Model In Drug Metabolismmentioning
confidence: 99%