Hollow and degradable polyelectrolyte nanocapsules for protein drug delivery

Shu, Shujun; Sun, Chunyang; Zhang, Xinge; Wu, Zhongming; Wang, Zhen; Li, Chaoxing

doi:10.1016/j.actbio.2009.06.020

Cited by 81 publications

(54 citation statements)

References 28 publications

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“…[ 182 ] PLLA microparticles acted as adhesion points for anchorage-dependent cells, and the LbL shell in combination with the liquefi ed environment enhanced the diffusion of the molecules for cell survival - Figure 19 . [ 171,172 ] These systems may also be customized to host different cell types and microparticles.…”

Section: Reviewmentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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Particulate systems have been widely used as containers of drugs or cells with the purpose of releasing them in a particularThe search for more effi cient therapeutic strategies and diagnosis tools is a continuous challenge. Advances in understanding the biological mechanisms behind diseases and tissues regeneration have widened the fi eld of applications of particulate systems. Particles are no more just protective systems for the encapsulated drugs, but they play an active role in the success of the therapy. Moreover, particles have been explored for innovative purposes as templates for cells growth and as diagnostic tools. Until few years ago the most relevant parameters in particles formulation were the chemistry and the size. Currently, it is known that other physical characteristics can remarkably affect the performance of particulate systems. Particles with non-conventional shapes exhibit advantages due to the increasing circulation time in blood stream, less clearance by the immune system and more effi cient cell internalization and traffi cking. Creation of compartments has been found useful to control drug release, to tune the transport of substances across biological barriers, to supply the target with more than one bioactive agent or even to act as theranostic systems. It is expected that such complex shaped and compartmentalized systems improve the therapeutic outcomes and also the patient's compliance, acting as advanced devices that serve for simultaneous diagnosis and treatment of the disease, combining agents of very different features, at the same time. In this review, we overview and analyse the most recent advances in particle shape and compartmentalization and applications of newly designed particulate systems in the biomedical fi eld.

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Section: Reviewmentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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“…They undergo controllable volume changes in response to small variations in pH of the external environment, which facilitate drug delivery control. To date, pH-sensitive polyelectrolyte polymers based on hollow microcapsules prepared by the layer by layer (LBL) self-assembly of polyelectrolytes on colloidal particles have been extensively investigated [15][16][17][18][19][20][21][22][23]. Möhwald and co-workers prepared hollow poly(allylamine hydrochloride) and sodium poly(styrene sulfonate) (PAH/PSS) microcapsules and confirmed the controlled encapsulation and release of several kinds of species, such as dyes [18], enzymes [19], dextran [20] and DNA [21], from the capsules by changing the pH of the release medium.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous silica nanotubes coated with multilayered polyelectrolytes for pH-controlled drug release

et al. 2010

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“…Common examples of PEs include biologically important molecules like DNA, RNA and proteins [1][2][3] . PEs also find applications in industries such as chemical [4][5][6][7] , pharmaceutical [8][9][10][11] , food 12,13 etc. The mechanical and chemical properties of a PE depend on its conformational state, which could vary from being linear and extended to compact and collapsed.…”

Section: Introductionmentioning

confidence: 99%

Regimes of electrostatic collapse of a highly charged polyelectrolyte in a poor solvent

et al. 2017

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We perform extensive molecular dynamics simulations of a highly charged, collapsed, flexible polyelectrolyte chain in a poor solvent for the case when the electrostatic interactions, characterized by the reduced Bjerrum length B , are strong. We find the existence of several sub-regimes in the dependence of the gyration radius of the chain R g on B characterized by R g ∼ −γ B . In contrast to a good solvent, the exponent γ for a poor solvent crucially depends on the size and valency of counterions. To explain the different sub-regimes, we generalize the existing counterion fluctuation theory by including a more complete account of all possible volume interactions in the free energy of the polyelectrolyte chain. We also show that the presence of the condensed counterions modifies the effective attraction among the chain monomers and modulates the sign of the second virial coefficient in poor solvent conditions.

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Hollow and degradable polyelectrolyte nanocapsules for protein drug delivery

Cited by 81 publications

References 28 publications

Design Advances in Particulate Systems for Biomedical Applications

Design Advances in Particulate Systems for Biomedical Applications

Mesoporous silica nanotubes coated with multilayered polyelectrolytes for pH-controlled drug release

Regimes of electrostatic collapse of a highly charged polyelectrolyte in a poor solvent

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