HLA Typing for Class I and Class II Antigens in Iraqi Patients with Behçet’s Disease (Sporadic and Familial Cases)

Al-Joofy, Ikbal Kh.; Muslih, Raad K.; Mousawy, Khalida M.; Al-Waiz, Makram M.

doi:10.1007/0-306-48382-3_42

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…So wheather this is applicable to our condition is to be elucidated. A gain these results support what is reported in our further study (3) , that hyperproteniemia & hypoalbuminemia associated with higher rate of joint involvement occurrence in BD (3) .…”

Section: Resultssupporting

confidence: 92%

“…From 70 patients with Behcet's disease 38 patient have HLA-B51(5) allel as well presented in table 1. In agreement with few studies done by other workers (4) , significant increase in T.S.P., with significant decrease of S.A. was clearly observed This hyperprotenemia may be caused by an increase in concentration of specific polyclonal immunoglobulins as a result of infections, yet, B-cell activation with polyclonal antibodies production in those patients was clearly observed (3) . On the other hand ,hypoalbuminemia, is well accepted marker in many diseases & in most instances is due to many factors (7,8) , primarily the increase in catabolism following tissue damage of inflammation, with impaired synthesis or reduced absorption of amino acids caused by malabsorption syndromes or malnutrition (7,8) .…”

Section: Resultssupporting

confidence: 92%

“…Behcet's disease (BD) is considered as a chronic multi-systemic inflammatory disorder with mysterious aetio-pathegenesis (1,2,3) . Several biochemical abnormalities which in one way or another might play a role in the pathogenesis of this disease (3,4) . Whereas HLA B51(5) molecules by themselves could be responsible in BD (5,6) .…”

Section: Introductionmentioning

confidence: 99%

“…Protein most often measured specifically, its function include control of fluid distribution between plasma, & the extracellular compartment, and binding with consequent inactivation of many endogenous & exogenous substances (7,8) while globulin play crucial role in the transport, storage, defence, blood clotting, maintenance of osmotic pressure, and other functions (7,8) . Several reports denote that hypoalbuminemia, and hypergama-globulinemia could be observed in BD patients (3,6) . This study was designed to measure serum total protein, albumin, globulin, and to elucidate the role of these biochemical elements in the pathogenesis of this disease in Iraqi patients…”

mentioning

confidence: 99%

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Changes in serum levels of Total protein , Albumin and Globulin in patients with Behcet's Disease.

Ikbal¹,

Raad²,

Khalida³

2005

AJPS

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In order to have an idea about some of biochemical changes which might play a role in the pathogenesis of Behcet's disease. Estimation of serum total protein, albumin, globulin and HLA typing were carried out in 70 patients with Behcets disease using colorematric, mathematic & microlymphocytotoxicity tests respectively, compared with 35 patients with recurrent oral ulcers, and 35 healthy control group.Hyperproteinemia, hyperglobulinemia with hypoalbuminemia were observed in those patients in comparison to control groups

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Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Changes in serum levels of Total protein , Albumin and Globulin in patients with Behcet's Disease.

Ikbal¹,

Raad²,

Khalida³

2005

AJPS

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HLA–B51/B5 and the risk of Behçet's disease: A systematic review and meta‐analysis of case–control genetic association studies

Menthon

LaValley

Maldini

et al. 2009

Arthritis & Rheumatism

406

231

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Objective To quantify by meta-analysis the genetic effect of the HLA–B5 or HLA–B51 (HLA–B51/B5) allele on the risk of developing Behçet’s disease (BD) and to look for potential effect modifiers. Methods Relevant studies were identified using the PubMed Medline database and manual searches of the literature. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by using the random-effects model. Subgroup meta-analyses and meta-regression analyses were undertaken to investigate the effects of selected study-level parameters on the pooled OR. Heterogeneity was assessed using the I2 statistic. Pooled results were used to calculate population-attributable risks (PAR) for BD in relationship to HLA–B51/B5. Results A total of 4,800 patients with BD and 16,289 controls from 78 independent studies (published 1975–2007) were selected. The pooled OR of HLA–B51/B5 allele carriers to develop BD compared with noncarriers was 5.78 (95% CI 5.00–6.67), with moderate between-study heterogeneity (I2 = 61%). The subgroup analyses stratifying studies by geographic locations (Eastern Asia, Middle East/North Africa, Southern Europe, Northern/Eastern Europe) yielded consistent OR ranges (5.31–7.20), with I2 ranges of 52–70%. Univariate random-effects meta-regression indicated the percentage of male BD cases (P = 0.008) as a source of heterogeneity. The PAR within the various geographic areas were estimated at 32–52%. Conclusion The strength of the association between BD and HLA–B51/B5, and its consistency across populations of various ethnicities, lends further support to this allele being a primary and causal risk determinant for BD. Variations according to sex support an interaction of this allele with BD characteristics.

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Étude d’association des antigènes HLA classe I avec la maladie de Behçet dans le Sud tunisien

Kamoun

Mahfoudh

Frigui

et al. 2012

Pathologie Biologie

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HLA Typing for Class I and Class II Antigens in Iraqi Patients with Behçet’s Disease (Sporadic and Familial Cases)

Cited by 4 publications

References 5 publications

Changes in serum levels of Total protein , Albumin and Globulin in patients with Behcet's Disease.

Changes in serum levels of Total protein , Albumin and Globulin in patients with Behcet's Disease.

HLA–B51/B5 and the risk of Behçet's disease: A systematic review and meta‐analysis of case–control genetic association studies

Étude d’association des antigènes HLA classe I avec la maladie de Behçet dans le Sud tunisien

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