HLA matching in unrelated donor bone marrow transplantation

Charron, Dominique

doi:10.1097/00062752-199603060-00004

Cited by 17 publications

(6 citation statements)

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“…Many of the Burmese and Karen HLA haplotypes reconstructed in this study were also found in Thais, Vietnamese and other Asian populations. However, we found a significant difference in the five‐locus haplotype frequency of A*33‐C*03:02‐B*58‐DRB1*03‐DQB1*02 between the Burmese and Karen and the Northeast Thais , Thais‐Chinese , Khin and Singaporian Chinese . The B*58‐DRB1*13 haplotype (1.8%) was present in Karen, but not in the Burmese; whereas B*58‐DRB1*03 (1.8%) was present in Burmese, but not in the Karen (Table S8).…”

Section: Allele Frequencies Of Hla Class I and Class Ii In 170 Burmesmentioning

confidence: 59%

HLA alleles and haplotypes in Burmese (Myanmarese) and Karen in Thailand

et al. 2015

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This is the first report on human leukocyte antigen (HLA) allele and haplotype frequencies at three class I loci and two class II loci in unrelated healthy individuals from two ethnic groups, 170 Burmese and 200 Karen, originally from Burma (Myanmar), but sampled while residing in Thailand. Overall, the HLA allele and haplotype frequencies detected by polymerase chain reaction sequence-specific primer (PCR-SSP) at five loci (A, B, C, DRB1 and DRQB1) at low resolution showed distinct differences between the Burmese and Karen. In Burmese, five HLA-B*15 haplotypes with different HLA-A and HLA-DR/DQ combinations were detected with three of these not previously reported in other Asian populations. The data are important in the fields of anthropology, transplantation and disease-association studies.

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Section: Allele Frequencies Of Hla Class I and Class Ii In 170 Burmesmentioning

confidence: 59%

HLA alleles and haplotypes in Burmese (Myanmarese) and Karen in Thailand

et al. 2015

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“…It is our current policy to aim for an A/B/Cw/DRB1/B3/B5/DQB1-allele matched (CTLpnegative) donor. 24 Due to the extremely high rates of DPmismatches, 4,5,10,25 this locus is not taken into account. Between 1995 and 1998, this strategy identified 'fully matched' donors for 38.4% of the patients for whom a search was started.…”

Section: Discussionmentioning

confidence: 99%

“…Not unexpectedly, Cw was the incompatibility most frequently found in the other ABDR-matched pairs. 4,8,10,11 For 17 (19.8%) patients (average of 5.5, range 1-14 donors tested/patient), the best matched donor was A/B/DRB1/B3/B5-allele matched, Cw-incompatible. Fully HLA-A/B/DRB1/B3/B5-compatible donors with a single DRB3 mismatch were identified for four patients (4.6%) with an average of 8.3 donors tested/patient (range 2-10).…”

Section: Potential Donors Identified In 104 Consecutive Searchesmentioning

confidence: 99%

“…This is probably due to hidden HLA incompatibilities that are targets for alloreactive CTLs. Indeed, we 5,6,8 and others 7,[9][10][11][12] have shown that a large fraction of 'ABDR-matched' patient-donor combinations are in fact mismatched at the allelic level when histocompatibility typing techniques with a higher resolution power are applied. Patient/donor matching policies differ from country to country, and may even vary from one centre to another.…”

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confidence: 99%

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Bone marrow transplantation with unrelated donors: what is the probability of identifying an HLA-A/B/Cw/DRB1/B3/B5/DQB1-matched donor?

Tiercy

Bujan-Lose

Chapuis

et al. 2000

Bone Marrow Transplant

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“…This latter application of class I typing by SBT is becoming increasingly important. As the availability of an HLA-matched sibling donor is at the most 35% of patients requiring an allogeneic bone marrow transplant, unrelated donors are frequently used as alternative sources of bone marrow (30). In these cases, a complete matching at the class I loci may be critical for the engraftment.…”

Section: Discussionmentioning

confidence: 99%

HLA‐A typing: comparison between serology, the amplification refractory mutation system with polymerasee chain reaction and sequencing

Pera¹,

Delfino²,

Morabito³

et al. 1997

Tissue Antigens

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In this study we typed HLA-A polymorphisms by a new sequence-based typing (SBT) method, which involved one PCR reaction and four sequencing reactions covering exon 2 and exon 3. This method allowed complete identification of all known HLA-A alleles and revealed the presence of a new allele, named HLA-A*2608. We also introduced sequencing of exon 4 for some samples in order to discriminate the allelic pairs that are identical in exon 2 and 3, thus improving SBT resolution. Finally, we compared the results obtained by SBT with data obtained by serological typing and the amplification refractory mutation system (ARMS-PCR). Together, our results suggest that the SBT here described provides an optimal HLA-A typing technique that may be useful in selecting donor-recipient pairs in bone marrow transplantation between unrelated individuals.

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HLA matching in unrelated donor bone marrow transplantation

Cited by 17 publications

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HLA alleles and haplotypes in Burmese (Myanmarese) and Karen in Thailand

HLA alleles and haplotypes in Burmese (Myanmarese) and Karen in Thailand

Bone marrow transplantation with unrelated donors: what is the probability of identifying an HLA-A/B/Cw/DRB1/B3/B5/DQB1-matched donor?

HLA‐A typing: comparison between serology, the amplification refractory mutation system with polymerasee chain reaction and sequencing

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