HLA markers and lymphocytotoxins in lichen planus

HLA antigens in patients with lichen planus

“…the HLA B 8 antigen has been detected with increased f r cquenC} . Saurat ( 11) reported similar findings in patients with lichen planus. This antigen was not found with increased f r equency among the patients in the current study.…”

“…When the available data on HLA tissue typing of patients with lichen planus are pooled ( the group of patients of Saurat et al ( 11), those of Lowe, Cud worth & Woodrow (7), and the group presented here) a total of I 89 patients and 2 858 controls have been examined (Table IV). The most marked devia tions were seen for HLA-A 3 (present in 33-54 % of the patients and 26-30 % of the controls).…”

Familial Lichen planus

“…HLA-A3 was found in 54% of a group of 57 nonfamilial LP patients compared with a control fre quency of 30% [18]. Subsequent studies, however, did not demonstrate statistically significant differences from con trols [ 19,20] and failed to find this HLA in FLP [8,16]. In a group of 72 nonfamilial LP patients [21] HLA DR1, which is in linkage disequilibrium with A3, was found to be more frequent (56%) compared with normal controls (25%).…”

Analysis of HLA antigens in Japanese with oral lichen planus

“…B 7 in familial LP (20), and B 8 in OLP (21). On the other hand, other studies reported no stich associations (22)(23)(24). Becker (1985) studied HLA-DR 1 to DR 7 antigens as well as Class 1 antigens in 21 Germans with OLP.…”