HLA in bullous pemphigoid

Localization of the human gene for 230-kDal bullous pemphigoid autoantigen (BPAG1) to chromosome 6pter→q15

“…Within this region, the HLA gene cluster is located at 6p21.3. Recent studies have indicated the association of BP with the HLA-DR5 haplotype (Seignalet et al, 1987), which is not incon sistent with our gene mapping data, although some other stud ies have suggested negative correlation between BP and HLA haplotypes (Ahmed et al. 1977(Ahmed et al.…”

Histocompatibility Antigens (Hla) in Dermatology

“…Although no one would use HLA typing for specific diagnostic purposes, it may be helpful in distinguishing differences between diseases. Unlike pemphigus, HLA typing is normal in pemphigoid (Ahmed et al, 1977), except in cicatricial ocular pemphigoid in which there is an increased incidence of B12 and possibly A3 (Mondino, Brown & Robin, 1978). HLA-B8 occurs in about 85% of patients with dermatitis herpetiformis (Katz et al, 1977;Buckley et al, 1983) but DR3 is probably the antigen primarily associated with the disease (Pehamberger, Holubar & Mayr, 1981).…”

IGHV3-Associated Restriction Fragment Length Polymorphisms Confer Susceptibility to Bullous Pemphigoid

“…In any case, it is pertinent to note that the polymorphism of the IGHV3 subgroup that encodes many autoantibodies [21] has been found to be associated with various autoimmune diseases including pemphigus vulgaris [19]. Thus, susceptibility locus might be present in the IGHV genes and participate in the development of BP in association with HLA genes [4] and IGK locus [12].…”

“…In this regard, many studies have focused on genes encoding molecules of the immunoglobulin (Ig) gene superfamily, i.e., genes of the human leukocyte antigens, Ig and T cell receptor complexes. The role of the major histocompatibility complex (MHC), in particular MHC class II genes, in the susceptibility to many autoimmune diseases is demonstrated [3] and BP was shown to be associated with HLA-DQB1*0301 [4,5]. Analysis of the role of Ig gene polymorphisms in the susceptibility to autoimmune diseases has involved both the heavy (H)-and light (L)-chain loci [6][7][8].…”