HLA in alopecia areata

Kavak, Ayşe; Baykal, Can; Özarmağan, Güzin; Akar, Uğur

doi:10.1046/j.1365-4362.2000.00921.x

Cited by 59 publications

(55 citation statements)

References 17 publications

(24 reference statements)

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“…The increased frequencies of HLA-B*27 in our study was accordant to the result from Russian [20]. In other studies, the frequencies of HLA-A1, HLA-B62 in Turkey [9], -B*12 in Finland [10], was significantly increased in AA patients compared with controls. However, we did not find these alleles were related to AA.…”

Section: Discussionsupporting

confidence: 90%

“…No locus was merely related to early onset of AA. Kavak et al [9] found patients with juvenile onset AA showed increased HLA-Cw7 frequency, but we found the frequency of HLACw*0704 were raised in all patients no matter their onset ages. The Kuwaiti children with AA were observed to have a significant association with HLA-B21, -B40 and -B12 antigens [22], which were different from our results.…”

Section: Discussioncontrasting

confidence: 82%

“…Current research has focused on HLA type and immune function in alopecia patients [6,7]. It is thought that HLA status may potentiate development of the AA phenotype and exists ethic differences [8][9][10][11]. However, no report has been published about HLA alleles associated with AA in Chinese Hans.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Association of HLA class I alleles with aloplecia areata in Chinese Hans

Xiao¹,

Yang²,

Yan³

et al. 2006

Journal of Dermatological Science

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Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 82%

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Association of HLA class I alleles with aloplecia areata in Chinese Hans

Xiao¹,

Yang²,

Yan³

et al. 2006

Journal of Dermatological Science

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“…Genetic susceptibility to AA results in increased concordance rates in family members and twins, and frequent co-diagnosis with other autoimmune disorders, such as vitiligo and autoimmune thyroiditis. Genetic associations have been reported between AA and several human leukocyte antigen (HLA) genes (Colombe et al, 1995;Kavak et al, 2000;Akar et al, 2002;Entz et al, 2006;Petukhova et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Association between TAP1 gene polymorphisms and alopecia areata in a Korean population

Hk¹,

H²,

Bl³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The transporter 1 ATP-binding cassette sub-family B (MDR/ TAP) gene (TAP1) is located in the major histocompatibility complex class 18821 TAP1 polymorphisms and alopecia areata ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 18820-18827 (2015) II region, and forms a heterodimer that plays a key role in endogenous antigen presentation pathways. Investigation of polymorphisms identified in these loci has revealed an association with several autoimmune disorders. Alopecia areata (AA) is a common autoimmune disease resulting from T cell-induced damage to hair follicles. The present study documents for the first time a comparison between the allelic and genotypic frequencies of TAP1 single nucleotide polymorphisms (SNPs) in patients with AA and those of a control group, using a direct sequencing method. Our results suggest an association between a promoter SNP (rs2071480) and susceptibility to this disease.

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“…But the mechanism by which HLA-B54 is associated with these diseases has not been fully analyzed. Concerning the HLA-Cw7 antigen, no study has revealed an association between this antigen and any disease except for juvenile-onset alopecia areata [31]. It is said that the HLA-Cw7 antigen downregulates the function of non-MHC-restricted CD4+ T lymphocytes [32], but whether or not this antigen affects the pathogenesis of endometriosis is not clear at this stage.…”

Section: Discussionmentioning

confidence: 99%

Studies on the Human Leukocyte Antigen Class I Antigens in Japanese Patients with Macroscopically Diagnosed Endometriosis

Ishii¹,

Takakuwa²,

Adachi³

et al. 2002

Gynecol Obstet Invest

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An increasing number of reports suggest that endometriosis is associated with abnormal immune function, although the etiology of the disease remains undefined. The human leukocyte antigen system (HLA) is known to play a role in the etiology of a number of diseases. This study examines the possible association between the HLA system and endometriosis. Fifty-five patients diagnosed with endometriosis by laparoscopic examination were typed for HLA class I antigens – HLA-A, -B, and -C antigens – using the standard microlymphocytotoxity technique of Terasaki. The frequency of HLA-B 54 and that of HLA-Cw7 were significantly higher in the patient population than in the control population. No significant difference was found between the two groups in the frequencies of the other HLA-class I antigens. The results of this study may implicate the HLA system in the development of endometriosis.

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HLA in alopecia areata

Abstract: In HLA-alopecia areata association, ethnic differences may play a role.

Cited by 59 publications

References 17 publications

Association of HLA class I alleles with aloplecia areata in Chinese Hans

Association of HLA class I alleles with aloplecia areata in Chinese Hans

Association between TAP1 gene polymorphisms and alopecia areata in a Korean population

Studies on the Human Leukocyte Antigen Class I Antigens in Japanese Patients with Macroscopically Diagnosed Endometriosis

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