HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for reproduction

Rajagopalan, Sumati

doi:10.1038/cmi.2014.53

Cited by 80 publications

(57 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The expression of HLA-G, a proposed ligand for KIR2DL4 (47), at the maternal-fetal interface has led to the suggestion that KIR2DL4 is involved in the maintenance of pregnancy. It is postulated that this interaction leads to the activation of NK cells and the secretion of factors that promote vascular remodeling in the uterus (48,49). To this end, some groups have reported an interaction with HLA-G, whereas other investigations suggest that it does not (23,24).…”

Section: Discussionmentioning

confidence: 99%

The Structure of the Atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4

Moradi

Berry

Pymm

et al. 2015

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: KIR2DL4 is an important natural killer cell receptor with properties distinct from other KIRs. Results: The D0 domain of KIR2DL4 drove self-association of the receptor. Conclusion: Among KIRs, the self-association of KIR2DL4 is unique and a result of discrete differences in its D0 domain. Significance: The self-association of KIR2DL4 has implications for its unique signaling and function.

show abstract

Section: Discussionmentioning

confidence: 99%

The Structure of the Atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4

Moradi

Berry

Pymm

et al. 2015

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…HLA-E can combine with another type of inhibitory receptor on NK cells, NKG2A, which limits the killing activity of NK cells. HLA-G has a function similar to that of HLA-E. Further study found that HLA-G can also induce tolerance of DCs and induce NK cells to secrete cytokines and angiogenesis factors, thus showing polyfunctionality (LeMaoult et al, 2004;van der Meer et al, 2004;Li et al, 2009;Rajagopalan, 2014). At the surface of the second interface, the syncytial trophoblast cells do not express MHC molecules; therefore, they cannot induce an antigen specific response from maternal T cells (Moffett-King, 2002).…”

Section: The Education Of Decidual Nk Cellsmentioning

confidence: 99%

Decidual natural killer cells and the immune microenvironment at the maternal-fetal interface

Wei

2016

Sci. China Life Sci.

View full text Add to dashboard Cite

During early pregnancy, an orchestrated evolutionary maternal adaption toward tolerance of the semiallogeneic fetus is required to ensure decidualization and early embryo development. Remodeling of the immune system involves natural killer cells (NKs), macrophages, T cells and dendritic cells (DCs) altering the microenvironment in the deciduas. In particular, a unique population of NK cells with a CD56 bright CD16− phenotype in the decidua has been proposed to play a key role in the maternal adaptation to pregnancy. However, there is a tendency for pregnancy immunology to reflect transplantation immunology regarding the assumption that the maternal immune system should be suppressed. This tendency is misleading. We discuss how the immune system is formed in early deciduas and the interactions between maternal NK cells and fetal growth. We propose that the maternal immune response must not be fully suppressed and is even necessary for the local response of uterine NK cells. NK cells, decidua, fetal growth, the immune microenvironment Citation:Fu, B., and Wei, H. (2016). Decidual natural killer cells and the immune microenvironment at the maternal-fetal interface.

show abstract

“…In particular, most of previous studies on NK cells have focused on mouse splenic and human peripheral blood NK cells, which are circulating and referred to as conventional NK (cNK) cells (Sojka et al, 2014b). However, NK cells have recently been attracting attention for their heterogeneous subsets based on tissue distribution (Rajagopalan, 2014;Shi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Tissue-resident natural killer cells in the livers

Peng

Tian

2016

Sci. China Life Sci.

View full text Add to dashboard Cite

Nature killer (NK) cells are important lymphocytes of the innate immune system, well known for their pivotal roles in immune surveillance and defense against tumor and virus-infected cells. Current studies have revealed that NK cells are not a homogeneous population, but instead consist of distinct subsets with diverse characteristics. As an organ with predominant innate immunity, the liver is enriched with NK cells, among which two distinct NK cell subsets have recently been identified: conventional NK (cNK) cells and tissue-resident NK (trNK) cells. Liver trNK cells are markedly different from cNK cells in many aspects, representing a new lineage of innate lymphoid cell (ILC) family. Here, we summarize the phenotypic and functional features of liver trNK cells, and review current knowledge regarding developmental pathway of liver trNK cells. We also overview recent advances in human liver trNK cells and discuss the striking shared hallmarks of trNK cells in different tissues.

show abstract

HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for reproduction

Cited by 80 publications

References 68 publications

The Structure of the Atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4

The Structure of the Atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4

Decidual natural killer cells and the immune microenvironment at the maternal-fetal interface

Tissue-resident natural killer cells in the livers

Contact Info

Product

Resources

About