HLA‐DRB1 and multiple sclerosis in Argentina

Patrucco, Liliana; Larriba, J.; Redal, María Ana; Rojas, Juan Ignacio; Argibay, Pablo; Cristiano, Edgardo

doi:10.1111/j.1468-1331.2008.02523.x

Cited by 26 publications

(22 citation statements)

References 12 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Caucasians, the HLA-DRB1∗1501 gene appears to confer most of the genetic susceptibility to MS [7]. Although Latin-American populations present singular genetic backgrounds, Argentinean MS patients show HLA class II gene frequencies similar to those observed in Caucasian populations [8]. In addition, genome-wide association studies have now revealed a large number of individual non-HLA genes modestly increasing MS risk [9].…”

Section: Discussionmentioning

confidence: 99%

Autoimmune Disease Prevalence in a Multiple Sclerosis Cohort in Argentina

Farez

Aguirre²,

Varela

et al. 2014

Multiple Sclerosis International

View full text Add to dashboard Cite

Background. Comorbid autoimmune diseases in MS patients have been studied extensively with controversial results. Moreover, no such data exists for Latin-American MS patients. Methods. We conducted a case-control study aimed to establish the prevalence of autoimmune disorders in a cohort of Argentinean MS patients. Results. There were no significant differences in autoimmune disease prevalence in MS patients with respect to controls. The presence of one or more autoimmune disorders did not increase risk of MS (OR 0.85, 95% CI 0.6–1.3). Discussion. Our results indicate absence of increased comorbid autoimmune disease prevalence in MS patients, as well as of increased risk of MS in patients suffering from other autoimmune disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Autoimmune Disease Prevalence in a Multiple Sclerosis Cohort in Argentina

Farez

Aguirre²,

Varela

et al. 2014

Multiple Sclerosis International

View full text Add to dashboard Cite

show abstract

“…Several genetic loci have been associated with MS or act as modifiers of disease progression, including HLA class II and the DR2 haplotype (HLADRB1 * 15, DQA1 * 01, DQB1 * 06) [92][93][94]. In addition, the IL-2 receptor and IL-7 receptor genes may also play roles in MS [95].…”

Section: Cd24 As a Genetic Modifier For Ms Riskmentioning

confidence: 99%

CD24: from a Hematopoietic Differentiation Antigen to a Genetic Risk Factor for Multiple Autoimmune Diseases

Tan

Zhao

Xiang

et al. 2015

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

The autoantibody is an essential characteristic of inflammatory disorders, including autoimmune diseases. Although the exact pathogenic mechanisms of these diseases remain elusive, accumulated evidence has implicated that genetic factors play important roles in autoimmune inflammation. Among these factors, CD24 was first identified as a heat-stable antigen in 1978 and first successfully cloned in 1990. Thereafter, its functional roles have been intensively investigated in various human diseases, especially autoimmune diseases and cancers. It is currently known that CD24 serves as a costimulatory factor of T cells that regulate their homeostasis and proliferation, while in B cells, CD24 is functionally involved in cell activation and differentiation. CD24 can enhance autoimmune diseases in terms of its protective role in the clonal deletion of autoreactive thymocytes. Furthermore, CD24 deficiency has been linked to mouse experimental autoimmune encephalomyelitis. Finally, CD24 genetic variants, including single-nucleotide polymorphisms and deletions, are etiologically relevant to autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus. Therefore, CD24 is a promising biomarker and novel therapeutic target for autoimmune diseases.

show abstract

“…It also raises new and intriguing questions regarding the interplay between environmental and genetic factors in MS. For example, the relative sibling risk ratio remains strikingly similar to that reported in other parts of the world, reflecting perhaps a similar genetic effect, with environmental factors somehow playing a greater role. Alternatively, although the Argentine population is composed mainly of Italian and Spanish immigrants, and HLA-DRB1 allele frequency in MS patients is similar to those reported in Caucasian populations [20], there is a potential role for native genes providing relative protection [21], a topic which needs to be addressed in future studies.…”

Section: Discussionmentioning

confidence: 79%