HLA-DRB1 and -DQB1 loci in three west African ethnic groups: Genetic relationship with sub-Saharan African and European populations

Human leukocyte antigen–A, –B, and –DRB1 allele and haplotype frequencies in the Mozambican population: A blood donor–based population study

“…Based on the haplotypes frequencies, most two-and three-locus HLA haplotype in the blood donors were HLA-A*30-B*42 (7.4%), HLA-A*30-DRB1*03 (6.6%), HLA-B*42-DRB1*03 (5.4%), HLA-A*30-B*42-DRB1*03 (4.9%), and HLA-A*02-B*58-DRB1*11 (4.1%). Although our results need confirmation by additional studies with greater number of participants [8], the predominant three haplotypes HLA-A-B-DRB1 frequencies are in accordance with the haplotypes previously reported in the sub-Saharan population [8,9,19].…”

“…Allele frequencies data for other sub-Saharan African populations were obtained from the previous studies: Kenyans (Nandi and Luo) [8], South Africans (Zulu and Vanda) [8,9], Ugandans [14], Zambians [8], Botswanians [15], Congolese from Democratic Republic of Congo (Bantu) [9], Ethiopians (Oromo) [9], and Zimbabweans (Shona) [9]. [20].…”

“…In addition, few studies have been conducted in populations from the sub-Saharan area [8 -10]. In fact, only four populations have been extensively studied in subSaharan Africa: the Zulu from South Africa [11], the Luo from Kenya [8], the Fulani from Burkina Faso [9], and the Maltasa Berber from the city of Nador, Marroco [10].…”

Absence of the human CYP2C8*3 allele in Ugandan children exposed to Plasmodium falciparum malaria

“…This requires further investigation in other parts of the continent to assess the presence of the allele. Moreover, the link between CYP2C8*3 and pfmdr1 should be tested in countries where the Caucasoid component is strong and malaria numbers are still enough to perform this association, as in all countries where Fulani ethnic group is present since there is a Caucasoid contribution in their gene pool (Modiano et al, 2001;Lulli et al, 2009). The possible confounding effect of age was calculated by binary logistic regression (BLR) OR (95% confidence interval).…”

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

“…This result provides a clear indication of the dominant role of diet over the variables mentioned above in shaping the microbial composition of the gut. Studies on the genetic variability between Mossi and Europeans showed polymorphisms in the major histocompatibility complex (MHC) genes (14), but no significant differences in the expression of key genes regulating immune function such as TGFβ, TGFβR, CTLA4, and FOXP3, suggesting a functional similarity (15). Also, the two populations are different for many other variables such as sanitation, hygiene, geography, and climate.…”