HLA-DQB1 and HLA-DPB1 genotypes in severe preeclampsia

Honda, Keisuke; Takakuwa, Koichi; Hataya, Isao; Yasuda, Masako; Kurabayashi, Takumi; Tanaka, Kenichi

doi:10.1016/s0029-7844(00)00918-2

Cited by 11 publications

(7 citation statements)

References 25 publications

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“…But they concluded that HLA-DQB1*0503 may be a marker in high blood pressures in pregnancy ( 21 ). In another study, Honda et al investigated the relationship of HLA-DQB1 and HLA-DPB1 to severe pregnancies and their data suggested that women who have the allele HLA-DQB1*04 might be susceptible to preeclampsia ( 22 ). Moreover, Ooki et al carried out an experiment in order to probe HLA class II alleles among couples with severe preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Relationship between human leukocyte antigen (HLA)-DQA10102/HLA-DQB10602 polymorphism and preeclampsia

Mohammadi

Farazmandfar

Shahbazi

2017

IJRM

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Background: Preeclampsia is a condition associated with systemic disorders in the mother and the fetus. However, the exact causes of preeclampsia are unknown, but several genetics and environmental factors play role in development of this disease. Major histocompatibility complex role is very important during pregnancy through which the fetus is not rejected by mother's immune system. Objective: In this study, we investigated the relationship of the human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism with preeclampsia. Materials and Methods: Genomic DNA of 181 pregnant women with a history of preeclampsia as the case group and 228 pregnant women with no history of preeclampsia as the controls were extracted. The HLA-DQA1*0102/HLA-DQB1*0602 polymorphisms of all DNA samples were identified by the SSP-PCR method. Frequencies difference of variables between case and control groups were calculated by Chi-square test. The ethnic origin of the participants in this study was extracted from their medical records. Results: There was a significant association between preeclampsia and Sistani ethnic group (p=0.031). Moreover, there was a significant association between preeclampsia and frequencies of allele HLA-DQB1*0602 (p<0.001), and genotypes of heterozygote (+0102/-0602) (p<0.001) and negative homozygote (-0102/-0602) (p=0.005). There also was an association between allele HLA-DQB1*0602 and preeclampsia in Fars ethnic group (p=0.028). Conclusion: It seems that immune incompatibility may have an important role in preeclampsia predisposition. According to our results, the lack of locus HLA-DQB1*0602 may be a risk factor for preeclampsia.

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Section: Discussionmentioning

confidence: 99%

Relationship between human leukocyte antigen (HLA)-DQA10102/HLA-DQB10602 polymorphism and preeclampsia

Mohammadi

Farazmandfar

Shahbazi

2017

IJRM

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“…Few publications have addressed the relationship between HLA genotypes and gestation period. However, a recent study reports that DQB10201 non‐asp 57 correlates with abortion [11] and that the DQB104 allele is associated with pre‐eclampsia [12]. The relationship between gestation period and risk of developing T1D in childhood is controversial.…”

Section: Discussionmentioning

confidence: 99%

Length of gestation and gender are associated with HLA genotypes at risk for Type 1 diabetes (Italian DIABFIN 3)

Locatelli¹,

Buzzetti²,

Galgani³

et al. 2007

Diabetic Medicine

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“…On the other hand, a genetic basis for pre‐eclampsia has also been suggested (25, 27). Several studies have examined the possible association between HLA system and pathogenesis of pre‐eclampsia (3–5). Recently, the only polymorphic HLA class I antigen expressed on the interface of the fetal–maternal HLA‐C is taken into consideration.…”

Section: Discussionmentioning

confidence: 99%

“…Chromosomal exclusion mapping suggested a role for genes on chromosome 1, 3, 9, or 18 (1), and a genomewide scan of 15 affected pedigrees identified a candidate region on chromosome 4 (2). Candidate genes such as human leukocyte antigen (HLA)‐DR, HLA‐DRB1, HLA‐DQB1, HLA‐DPB1 and currently, the only known polymorphic HLA expressed on fetal trophoblast, HLA‐C, has also been studied (3–6). These studies indicated that various genes may predispose to the pathogenesis of pre‐eclampsia.…”

Section: Introductionmentioning

confidence: 99%

Maternal human leukocyte antigen‐G polymorphism is not associated with pre‐eclampsia in a Chinese Han population

et al. 2006

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Pre-eclampsia is a multisystem disorder of pregnancy and remains the leading cause of both maternal and fetal morbidity and mortality in many countries. Despite extensive studies, the underlying mechanisms still remain unknown. Besides its restricted expression in the tissues of placenta and its function in regulating immune suppression and in ensuring successful invasion of placental tissues into maternal deciduas, it has been postulated that HLA-G may play a role in modulation of immune tolerance at the fetal-maternal interface. Aberrant HLA-G expression may result in pregnancy disorders that are associated with poor invasion of extravillous cytotrophoblast into maternal spiral arteries, such as pre-eclampsia. Studies have shown that pre-eclampsia is largely under genetic control, but genetic mechanisms underlying the disorder have yet to be determined. In the current study, we focus on the potential role of HLA-G polymorphism in the pathogenesis of pre-eclampsia. Samples were obtained from Chinese Han primiparous women with pre-eclampsia and irrelative normal women, and case-matched placentas were genotyped for the HLA-G polymorphism in the exons 2, 3, and 4, and the 14-base-pair (bp) insertion/deletion polymorphism in the 3'-untranslated region of exon 8 was analyzed separately. The frequency of HLA-G polymorphism in these samples was not significantly different from those of normal controls, indicating that maternal HLA-G polymorphism is not associated with the risk for pre-eclampsia in this Chinese Han population. However, the maternal 14-bp insertion/deletion polymorphism is ethnically different.

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HLA-DQB1 and HLA-DPB1 genotypes in severe preeclampsia

Abstract: These data suggest that women who have the HLA-DQB1*04 allele might be susceptible to preeclampsia.

Cited by 11 publications

References 25 publications

Relationship between human leukocyte antigen (HLA)-DQA10102/HLA-DQB10602 polymorphism and preeclampsia

Relationship between human leukocyte antigen (HLA)-DQA10102/HLA-DQB10602 polymorphism and preeclampsia

Length of gestation and gender are associated with HLA genotypes at risk for Type 1 diabetes (Italian DIABFIN 3)

Maternal human leukocyte antigen‐G polymorphism is not associated with pre‐eclampsia in a Chinese Han population

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HLA-DQB1 and HLA-DPB1 genotypes in severe preeclampsia

Abstract: These data suggest that women who have the HLA-DQB1*04 allele might be susceptible to preeclampsia.

Cited by 11 publications

References 25 publications

Relationship between human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism and preeclampsia

Relationship between human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism and preeclampsia

Length of gestation and gender are associated with HLA genotypes at risk for Type 1 diabetes (Italian DIABFIN 3)

Maternal human leukocyte antigen‐G polymorphism is not associated with pre‐eclampsia in a Chinese Han population

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Product

Resources

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Relationship between human leukocyte antigen (HLA)-DQA10102/HLA-DQB10602 polymorphism and preeclampsia

Relationship between human leukocyte antigen (HLA)-DQA10102/HLA-DQB10602 polymorphism and preeclampsia