1991
DOI: 10.1001/archderm.127.1.64
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HLA-D locus associations in alopecia areata. DRw52a may confer disease resistance

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Cited by 28 publications
(18 citation statements)
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“…Major histocompatibility genes on chromosome 6p21 encoding HLA antigens have been shown to be a major determining loci for autoimmune diseases including AA. 26,27 HLA-DQB1*0301, DQB1*0202, DRB1*1104, and DQA1*0501 are strongly associated with AA. [28][29][30] HLA associations, including HLA-DRB1*1302 and DQB1*0604 with atopic dermatitis and HLA-DQB1*03 and HLA-DRB1*04 with autoimmune hypothyroidism (ie, Hashimoto thyroiditis), have been also reported.…”
Section: Discussionmentioning
confidence: 99%
“…Major histocompatibility genes on chromosome 6p21 encoding HLA antigens have been shown to be a major determining loci for autoimmune diseases including AA. 26,27 HLA-DQB1*0301, DQB1*0202, DRB1*1104, and DQA1*0501 are strongly associated with AA. [28][29][30] HLA associations, including HLA-DRB1*1302 and DQB1*0604 with atopic dermatitis and HLA-DQB1*03 and HLA-DRB1*04 with autoimmune hypothyroidism (ie, Hashimoto thyroiditis), have been also reported.…”
Section: Discussionmentioning
confidence: 99%
“…Certain haplotypes seem to be associated with predisposal of the individual towards autoimmunity. AA may have MHC class II restriction (61)(62)(63)(64)(65)(66)(67). Recently, AA has been shown to be associated with several MHC class II antigens, HLA-DQ3, DR4, and DR11.…”
Section: Circumstantial Evidence That Aa Is An Autoimmune Inflammatormentioning
confidence: 99%
“…Disease association studies, conducted in unrelated individuals with AA, have shown that there are signi®cant HLA associations between AA and alleles at both the HLA class I and the HLA class II loci (Kianto et al, 1977;Kuntz et al, 1977;Hacham-Zadeh et al, 1981;Averbakh and Pospelo, 1986;Frentz et al, 1986;Duvic et al, 1991;Welsh et al, 1994;Colombe et al, 1995). Genetic association studies assume that the disease locus and the selected markers will be tightly linked in the population.…”
Section: Discussionmentioning
confidence: 99%
“…The HLA-DQB1 genes in linkage disequilibrium with HLA-Dw11 were also signi®cantly increased (Morling et al, 1991;Welsh et al, 1994;Colombe et al, 1995). Genes that may protect against manifesting AA have also been suggested, e.g., HLADRw52 a (Duvic et al, 1991).…”
Section: Discussionmentioning
confidence: 99%
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