HLA common and well‐documented alleles in China

Abstract

The American Society for Histocompatibility and Immunogenetics HLA common and well‐documented (CWD) catalog, CWD 2.0.0 catalog and European Federation for Immunogenetics (EFI) CWD catalog have been published, which are useful for improving the accuracy of HLA genotyping in laboratories. Here, we studied the Chinese HLA CWD catalog. A total of 812 211 unrelated volunteer donors from the China Marrow Donor Program (CMDP) were analyzed. Six hundred seventy‐six alleles at the HLA‐A, ‐B, ‐C, ‐DRB1, and ‐DQB1 loci were defined as CWD alleles in the Chinese population, including 159 common and 517 well‐documented alleles. The distribution of HLA alleles in the Chinese CWD catalog is different from that in the EFI CWD catalog. Thirty‐two percent (215/676) of CWD alleles in the Chinese CWD catalog are shared with those in the EFI CWD catalog. Fifty‐six percent (380/676) of alleles in the Chinese CWD catalog are not found in the EFI CWD catalog, while 655 alleles in the EFI CWD catalog are neither common nor well‐documented alleles in the Chinese CWD catalog. The Chinese CWD catalog described in this study may help to improve high‐resolution histocompatibility testing for CMDP‐accredited laboratories in China. However, to accommodate an increasing number of HLA alleles, this Chinese CWD catalog should be regularly updated.

Identification of the novel HLA‐C*03:365 allele in a Chinese bone marrow donor

“…According to the latest version of the IPD‐IMGT/HLA Database release 3.34 version (2018‐10), a total of 20 088 alleles for HLA loci have been found in populations from around the world, including 4374 alleles for HLA‐C locus. It was reported that 125 common and well documented (CWD) HLA‐C alleles were found in the Chinese population from the database of the China Marrow Donor Program (CMDP) . In this report, we describe the identification of the new allele HLA‐C*03:365 , which has been found in a Chinese bone marrow donor.…”

Identification of the novel HLA‐B*40:357 allele by polymerase chain reaction sequence‐based typing

“…It was reported that the top three most frequent alleles in HLA‐B locus were HLA‐B*40:01 , B*46:01 and B*58:01 with the frequency of 14.08%, 12.20% and 8.50%, respectively in the Zhejiang Han population, China . According to the data of the Chinese Marrow Donor Program Database (CMDP), the HLA‐B*40:01 allele is common in the Chinese Han population . Here, we describe a novel allele HLA‐B*40:357 , which differs from HLA‐B*40:01 by one nucleotide substitution.…”

Characterization of the novel HLA‐B*46:01:23 allele in a Chinese bone marrow donor

“…The HLA molecule shows particularly high levels of polymorphism, and the distributions of HLA alleles and haplotypes are varied among different populations. According to the HLA common and well‐documented alleles in China, HLA‐B*46:01 is a common allele in the Chinese population. It was reported that the frequency of the HLA‐B*46:01 allele was 11.87% in the Zhejiang Han population, China .…”