Hla‐b27 in mexican patients with ankylosing spondylitis

Fraga, Ana; Gorodezky, Clara; Lavalle, C; Castro‐Escobar, L. E.; Magaña, L; Escobar‐Gutiérrez, Alejandro

doi:10.1002/art.1780220315

Cited by 17 publications

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Multiple studies show a lower frequency of HLA-B27 in Latin America: for example, in 68% to 80% of Mexican patients 32,35 and 78% of Brazilian patients. In our study the frequency of HLA-B27 was 71% in 570 patients in the LA group and 83% in the EU groups.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Clinical Expression of Patients with Ankylosing Spondylitis from Europe and Latin America

Mariana

Muñoz-Gomáriz²,

Font³

et al. 2012

J Rheumatol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of the Clinical Expression of Patients with Ankylosing Spondylitis from Europe and Latin America

Mariana

Muñoz-Gomáriz²,

Font³

et al. 2012

J Rheumatol

View full text Add to dashboard Cite

show abstract

“…Thus several groups have reported DR1, 7 DR4, 8 B60, 9 and A9 (A*2402) 10 associations with AS and a contradictory association with DR8. 11 Apart from HLA-B27, 12 13 particularly B*2705, 14 AS and other SpA in Mexicans have been associated with HLA-B39, FC31, DR8, and LMP2. 15 17 However, owing to the small number of patients included in those studies and the tissue type techniques used in some of them, the association of such alleles with disease needs to be confirmed.…”

mentioning

confidence: 97%

Effect of HLA-B and HLA-DR genes on susceptibility to and severity of spondyloarthropathies in Mexican patients

Vargas‐Alarcón

Londoño²,

Hernández-Pacheco³

et al. 2002

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

Objective: To investigate the role of HLA-B and HLA-DR genes as contributors to genetic susceptibility and clinical expression of the spondyloarthropathies (SpA) , OR=28.7), HLA-DR1 (pC=0.045, OR=2.77), and HLA-B15 (p=0.034, pC=NS, OR=2.04) alleles in the whole group were found. HLA-B27 strength of association (OR) was 41.4 in AS; 20.9 in undifferentiated SpA; 27.2 in reactive arthritis. HLA-DR1 and HLA-B15 were increased in undifferentiated SpA (pC=0.045, OR=2.98 and p=0.004, pC=NS, OR=2.75). By analysing 58 HLA-B27 negative patients it was found that HLA-B15 and HLA-DR1 associations with SpA were independent of HLA-B27; increased frequencies of HLA-B15 were found in the whole SpA group and in patients with undifferentiated SpA (pC=0.03, OR=3.09 and pC<0.01, OR=3.77) and of HLA-DR1 in the latter (p=0.04, pC=NS, OR=3.15). HLA-B27 positive patients were younger than HLA-B27 negative patients at onset (p=0.03), but HLA-DR1 positive patients were older than HLA-DR1 negative patients (p=0.03). Bath indices for disease activity and functioning were higher in HLA-B27 positive patients (p=0.006 and p=0.004 v HLA-B27 negative patients). In contrast, neither HLA-DR1 nor HLA-B15 influenced these indices. Conclusion: Apart from HLA-B27, there is a significant association of HLA-DR1 and HLA-B15 with SpA in Mexicans which is independent of B27. HLA-B27 is associated with younger age at onset and increased disease severity and HLA-DR1 with older age at onset. The strength of HLA-B15, HLA-B27, and HLA-DR1 associations varied in different forms of SpA.T he spondyloarthropathies (SpA) are a heterogeneous group of diseases characterised by axial as well as peripheral enthesitis and arthritis and less commonly by a range of extra-articular manifestations. SpA are strongly linked to genetic factors and in some patients to infections with arthritogenic bacteria. Their presentation and clinical course seem, additionally, influenced by ethnicity, age at onset, and sex.

show abstract

“…De la misma manera, Londoño, et al, encontraron, también, en una serie de 139 pacientes, que la frecuencia de positivos para el HLA-B27 era de 60 % para el grupo general (6). En latitudes similares, como en Brasil, el HLA-B27 en espondilitis anquilosante es positivo en 78 % (7) y, en México, en 68 % de los casos (8). Estos datos, en general, contrastan con la gran frecuencia de HLA-B27 en países nórdicos y de Europa oriental (mayor de 90 %) (9).…”

Section: Alelos De Clase Iunclassified

Frequency of HLA alleles class I and II in a cohort of northwestern Colombian patients with spondyloarthritis

Velásquez¹,

Quintero²,

Aristizábal³

et al. 2011

biomedica

View full text Add to dashboard Cite

Objective. The frequency of HLA class I and II was determined in a population of patients with spondyloarthritis with respect to detection in the clinical setting and by radiology. Materials and methods. A descriptive, observational, cross-sectional, retrospective and prospective study was conducted in 56 patients from northwestern Colombia. Each was diagnosed with spondyloarthritis between 2005 and 2008. In each case, alleles were identified for the loci HLA class I and II (HLA-B; HLADQB1 and HLADRB). The frequency of these alleles in the axial, peripheral, extraarticular and radiological manifestations. Results.The frequency of HLA-B27 was 50% overall, and it was the most frequent allele. The two other alleles were HLA.DRB4*01 at 35.7% and HLA-DQB1*0501 at 28.6%, as detected in each of the clinical and radiological manifestations. A high frequency of HLA-B27 and HLA-DRB4*01 (64.3%) was noted in patients with dactylitis. Conclusion.The alleles HLA-B27, HLA-DRB4*01 and HLA-DQB1*0501 were common in the different subtypes of spondyloarthritis and were frequent in the specific clinical axial, peripheral and extraarticular clinical manifestations, as well as radiological sacroiliitis.

show abstract

Hla‐b27 in mexican patients with ankylosing spondylitis

Abstract: REFERENCES

Cited by 17 publications

References 2 publications

Comparison of the Clinical Expression of Patients with Ankylosing Spondylitis from Europe and Latin America

Comparison of the Clinical Expression of Patients with Ankylosing Spondylitis from Europe and Latin America

Effect of HLA-B and HLA-DR genes on susceptibility to and severity of spondyloarthropathies in Mexican patients

Frequency of HLA alleles class I and II in a cohort of northwestern Colombian patients with spondyloarthritis

Contact Info

Product

Resources

About