HLA-B*58:01 for Allopurinol-Induced Cutaneous Adverse Drug Reactions: Implication for Clinical Interpretation in Thailand

Sukasem, Chonlaphat; Jantararoungtong, Thawinee; Kuntawong, P.; Puangpetch, Apichaya; Koomdee, Napatrupron; Satapornpong, Patompong; Supapsophon, Patcharin; Klaewsongkram, Jettanong; Rerkpattanapipat, Ticha

doi:10.3389/fphar.2016.00186

Cited by 60 publications

(45 citation statements)

References 31 publications

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“…Association of HLA-A 31:01 with carbamazepine – induced SJS have been reported in children [60]. A study in Thailand concluded that there is an association between HLAB (*) 58:01 and allopurinol-induced SJS-TEN in a Thai population [61]. Similar findings were obtained in Korean cases [62].…”

Section: Discussionmentioning

confidence: 57%

Bibliometric analysis of literature on toxic epidermal necrolysis and Stevens-Johnson syndrome: 1940 – 2015

Sweileh

2017

Orphanet J Rare Dis

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BackgroundStevens Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but fatal adverse skin reactions that affect all age groups. In order to better understand literature on this topic, we conducted a bibliometric study using Scopus database to shed light on number and growth of publications, most active countries, institutions, journals and authors involved in publishing articles in this field, citation analysis, top cited articles, international collaboration, role of medications and genetic association. Bibliometric analysis will enrich the literature on these rare conditions and will provide baseline data for future comparison.ResultsThree thousand eight hundred fifty-six journal articles were retrieved. The h-index of retrieved documents was 95. Growth rates of publications were highest from 1966 to 1975 and from 2006 to 2015. The United States of America (n = 640; 16.57%) was the leading country in number of publications. However, French and Japanese researchers and institutions were most active in publishing articles on SJS and TEN. International collaboration among active countries was relatively low and ranges from 32.5% for Swiss researchers and 1.47% for Spanish researchers. The most frequently mentioned medication in retrieved articles was carbamazepine (n = 146) followed by phenytoin (n = 114) and allopurinol (n = 112). Mycoplasma infection was mentioned in 111 articles. Most documents on SJS and TEN were published in dermatology journals, specifically Archives of Dermatology. However, in the last decade, top cited articles appeared in dermatology and pharmacogenetic journals. Carbamazepine was frequently encountered with Han Chinese and HLA-B 1502 terms while allopurinol was frequently encountered with HLA-B 5801 and Japanese terms.ConclusionBibliometric analysis reveals that research publications on SJS and TEN have been increasing since the l940s, with relatively low international collaboration. Documents are being published, not only in dermatology journals, but also in genetic, public health and general medicine journals. Research on SJS and TEN can be helpful to clinicians and researchers not only to document complications and fatal outcomes, but also to identify potential causative agents and potential ethnic variations to note gaps in research.

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Section: Discussionmentioning

confidence: 57%

Bibliometric analysis of literature on toxic epidermal necrolysis and Stevens-Johnson syndrome: 1940 – 2015

Sweileh

2017

Orphanet J Rare Dis

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“…These patients were admitted to the hospital for treatment of CTX-induced SCARs between 2014 and 2017 and were prospectively enrolled in our study. The patients recruited in the present study are different from those previously reported by Kongpan et al 13 The RegiSCAR criteria were used to diagnose and classify SCARs, 18,19 and a dermatologist and allergist confirmed the diagnoses based on the photographs, pathological slides, clinical morphology, and medical records. SJS was defined as a mucocutaneous disorder characterized by skin rash and skin detachment affecting < 10% of the body surface area.…”

Section: Patient Recruitmentmentioning

confidence: 85%

Genetic Association of Co‐Trimoxazole‐Induced Severe Cutaneous Adverse Reactions Is Phenotype‐Specific: HLA Class I Genotypes and Haplotypes

Sukasem

Pratoomwun

Satapornpong

et al. 2020

Clin Pharma and Therapeutics

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Co-trimoxazole (CTX) causes various forms of severe cutaneous adverse reactions (SCARs). This case-control study was conducted to investigate the involvement between genetic variants of human leukocyte antigen (HLA) and CYP2C9 in CTX-induced SCARs, including Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS) in Thai patients. Thirty cases of CTX-induced SCARs were enrolled and compared with 91 CTX-tolerant controls and 150 people from the general Thai population. Cases comprised 18 SJS/TEN and 12 DRESS patients. This study demonstrated that genetic association of CTX-induced SCARs was phenotype-specific. HLA-B*15:02 and HLA-C*08:01 alleles were significantly associated with CTXinduced SJS/TEN, whereas the HLA-B*13:01 allele was significantly associated with CTX-induced DRESS. In addition, a significant higher frequency of HLA-A*11:01-B*15:02 and HLA-B*13:01-C*03:04 haplotypes were detected in the group of CTX-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and DRESS cases, respectively. Genetic association of CTX-induced SCARs is phenotype-specific. Interestingly, these association was observed only in HIV-infected patients but not in non-HIV-infected patients.

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“…HLA-DQB1, human leukocyte antigen-DQB1; AF, allele frequency; CF, carrier frequency; HW, Hardy-Weinberg equilibrium; Significantly different p-value < 0.05. (Cristallo et al, 2011;Sukasem et al, 2014;Su et al, 2016;Sukasem et al, 2016) HLA-C*03:02 SJS/TEN 7.77 7.50 6.00 10.00 9.00 5.71 0.7394 (Cristallo et al, 2011;Li et al, (Chantarangsu et al, 2009;Sukasem et (Continued) ( Tables 7, 8A). Moreover, co-trimoxazole-induced SJS/TEN associated with HLA-B*15:02 (7.66%) and -C*08:01 (10.32%) alleles was higher within Thai population than that of African Americans, Caucasians, Hispanics, and North American.…”

Section: Distribution Of Pharmacogenetics Markersmentioning

confidence: 99%

Genetic Diversity of HLA Class I and Class II Alleles in Thai Populations: Contribution to Genotype-Guided Therapeutics

et al. 2020

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alleles from Thai population with HLA alleles from both European and Asian countries, the distribution landscape of HLA-associated drug hypersensitivity across many countries could be observed. Consequently, this pharmacogenetics database offers a comprehensive view of pharmacogenetics marker distribution in Thailand that could be used as a reference for other Southeast Asian countries to validate the feasibility of their future pharmacogenetics deployment.

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HLA-B*58:01 for Allopurinol-Induced Cutaneous Adverse Drug Reactions: Implication for Clinical Interpretation in Thailand

Cited by 60 publications

References 31 publications

Bibliometric analysis of literature on toxic epidermal necrolysis and Stevens-Johnson syndrome: 1940 – 2015

Bibliometric analysis of literature on toxic epidermal necrolysis and Stevens-Johnson syndrome: 1940 – 2015

Genetic Association of Co‐Trimoxazole‐Induced Severe Cutaneous Adverse Reactions Is Phenotype‐Specific: HLA Class I Genotypes and Haplotypes

Genetic Diversity of HLA Class I and Class II Alleles in Thai Populations: Contribution to Genotype-Guided Therapeutics

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