HLA Antigens in Mucocutaneous Lymph Node Syndrome

A genomewide linkage analysis of Kawasaki disease: evidence for linkage to chromosome 12

“…The association between HLA and development of KD remains controversial (Barron et al 1992;Fildes et al 1992;Kaslow et al 1985;Krensky et al 1981Krensky et al , 1983Matsuda et al 1977). No evidence of linkage was observed in the 6p21 region in the present study, which might indicate that HLA does not play a major role in terms of KD susceptibility.…”

HLA Bw51 is increased in mucocutaneous lymph node syndrome in Israeli patients

“…It may be worth mentioning that patients G.S., though H L A Bw51 negative, had an HLA identical sib who contracted the disease at the age of 60 months. Matsuda et al, in 1977, did not notice a significant increase in any of the antigens they examined in their 32 Kawasaki patients. It was in contrast to Kato et al who in 1978 found a significant increase in Bw22 among 205 Japanese patients (Kato et al 1978).…”

A sibship with recurrent Kawasaki disease and coronary artery lesion

“…In our familial study on HLA phenotype, we found that the three affected siblings had a common haplotype (A2; Bw46; Cwll; DRw8) inherited from the father. Previous reports of HLA haplotypes in Japanese patients with K D have suggested a weak association with HLA-B22 (11,12). Studies from the USA (13,14) and Israel (15) have found an association between HLA-Bw5 1 and KD.…”