HLA antigens in keloids and hypertrophic scars

Laurentaci, G.

doi:10.1001/archderm.113.12.1726

Cited by 15 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These phenotypic features are indicative of a delayed-type immune reaction and support the hypothesis that immunological mechanisms are involved in the pathogenesis of pathologic scars, and that cell-mediated, major histocompatibility complex (MHC)-class IIrestricted immune responses may play an important role in HS and K [5,13,15,18,25,26]. Both in vivo and in vitro studies have demonstrated that T lymphocytes and macrophages possess the capacity to regulate essential steps in the process of wound healing and exert a regulatory influence over fibroblast activity [3,8,21].…”

Section: Discussionmentioning

confidence: 64%

Keloids and hypertrophic scars of Caucasians show distinctive morphologic and immunophenotypic profiles

et al. 2000

View full text Add to dashboard Cite

The aim of this study was to identify possible morpho-phenotypic differences between keloids (K) and hypertrophic scars (HS) in a Caucasian population. Young HS (< or =1 year of age) presented a high number of diffusely distributed spindle-shaped cells (alpha-smooth-muscle actin+ and fibronectin+). Fully developed HS (> 1 year of age and <3 years of age) were characterized by the frequent presence of distinct collagenous cellular nodules (cells: alpha-smooth-muscle actin+ and fibronectin+). Old HS (> or =3 years of age) showed widespread collagenization phenomena. The histological profile of K was not related to the age of the lesion and was characterized by the almost constant presence of abnormally thick, hyalinized collagen fibers, the presence of collagenous cellular nodules, and variable--albeit lower than in HS-- expression of alpha-smooth-muscle actin and fibronectin. Ultrastructurally, myofibroblasts were the predominant cell type in young and fully developed HS and in K. The immune-cell infiltrate was composed of CD3+, CD45RO+, CD4+, human lymphocyte antigen (HLA)-DR+, and lymphocyte function associated antigen (LFA)-1+ T lymphocytes, strictly associated with CD1a+/ CD36+, HLA-DR+, and intercellular adhesion molecule (ICAM)-1+ dendritic cells, both in HS and K. However, different amounts of immune cells were observed in relation to the type and age of the lesion, and these findings support the hypothesis that cell-mediated, major histocompatibility complex (MHC)-class II-restricted immune responses play an important role in the development of HS and K.

show abstract

Section: Discussionmentioning

confidence: 64%

Keloids and hypertrophic scars of Caucasians show distinctive morphologic and immunophenotypic profiles

et al. 2000

View full text Add to dashboard Cite

show abstract

“…However, these hypotheses still need to be confirmed by further investigations. In other studies, in 1977 Laurentaci and Dioguardi [21] found HLA-B14 and BW16 antigens associated with keloids. …”

Section: Discussionmentioning

confidence: 85%

Association of HLA-DQA1 and DQB1 alleles with keloids in Chinese Hans

Wang

Yang

et al. 2008

Journal of Dermatological Science

View full text Add to dashboard Cite

“…However, these hypotheses still need to be confirmed by further investigations. In 1977, Laurentaci and Dioguardi [26] observed HLA-B14 and B16 antigens associated with keloids. Later, Rossi and Bozzi [27] noted that HLA-B21 and DQw3 antigens associated with keloids also.…”

Section: Discussionmentioning

confidence: 99%

Association of HLA class I alleles with keloids in Chinese Han individuals

Lu¹,

Cai²,

Wang³

et al. 2010

Human Immunology

View full text Add to dashboard Cite

Keloids are benign fibroproliferative dermal tumors of unknown etiology. Some studies have suggested that human HLA status might potentiate development of keloids phenotype. No report has been published about HLA class I alleles associated with keloids in Chinese Han individuals. To investigate the etiology of keloids, the polymerase chain reaction-sequence-specific primer (PCR-SSP) method was used to analyze the distribution of HLA class I alleles in 192 patients with keloids and 252 healthy controls in a Chinese Han population. The frequencies of HLA-A*03 (6.77% vs 0%, p(c) < 10(-7)), A*25 (10.16% vs 4.56%, p(c) = 0.0111), B*07 (7.81% vs 2.58%, p(c) = 0.0080), and Cw*0802 (19.79% vs 10.32%, p(c) = 0.0004) were significantly increased in keloid patients, whereas the frequency of HLA-A*01 (18.75% vs 38.10%, p(c) < 10(-7)) was highly decreased, compared with that in healthy controls. The A*03-B*07, A*25-B*07, A*03-Cw*0802, A*25-Cw*0802, and B*07-Cw*0802 were found as high-risk haplotypes in developing keloids in this study. No extended haplotype was found to be significantly related to keloids. Through stratified analysis, the association of subgroups (single site/multiple site, severity, and family history) of keloid patients with specific HLA alleles was identified. Our data suggest these alleles may be keloids susceptibility genes or may be in close linkage with the susceptibility genes.

show abstract

HLA antigens in keloids and hypertrophic scars

Cited by 15 publications

References 0 publications

Keloids and hypertrophic scars of Caucasians show distinctive morphologic and immunophenotypic profiles

Keloids and hypertrophic scars of Caucasians show distinctive morphologic and immunophenotypic profiles

Association of HLA-DQA1 and DQB1 alleles with keloids in Chinese Hans

Association of HLA class I alleles with keloids in Chinese Han individuals

Contact Info

Product

Resources

About