HLA antigens in alopecia areata

Kuntz, B. M.

doi:10.1001/archderm.113.12.1717b

Cited by 14 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Certain haplotypes seem to be associated with predisposal of the individual towards autoimmunity. AA may have MHC class II restriction (61)(62)(63)(64)(65)(66)(67). Recently, AA has been shown to be associated with several MHC class II antigens, HLA-DQ3, DR4, and DR11.…”

Section: Circumstantial Evidence That Aa Is An Autoimmune Inflammatormentioning

confidence: 99%

Alopecia areata: an autoimmune disease?

McElwee

Tobin

Bystryn

et al. 1999

Experimental Dermatology

100

View full text Add to dashboard Cite

Section: Circumstantial Evidence That Aa Is An Autoimmune Inflammatormentioning

confidence: 99%

Alopecia areata: an autoimmune disease?

McElwee

Tobin

Bystryn

et al. 1999

Experimental Dermatology

100

View full text Add to dashboard Cite

“…The triggers for the onset of AA are unknown, but the resistance of the AA lesion to treatment, its persistence and regression, and its extent over the body may be influenced by the presence and interaction of several genes. The focus in human AA has been on HLA-D as the most likely region for genes that regulate susceptibility or resistance to disease, on the assumption that AA has an autoimmune basis [70,[86][87][88][89][90][91][92][93].…”

Section: Genetics In Aamentioning

confidence: 99%

Comparison of Alopecia areata in Human and Nonhuman Mammalian Species

et al. 1998

View full text Add to dashboard Cite

Alopecia areata (AA) is a nonscarring form of inflammatory hair loss in humans. AA-like hair loss has also been observed in other species. In recent years the Dundee experimental bald rat and the C3H/HeJ mouse have been put forward as models for human AA. AA in all species presents with a wide range of clinical features from focal, locally extensive, diffuse hair loss, to near universal alopecia. Histologically, all species have dystrophic anagen stage hair follicles associated with a peri- and intrafollicular inflammatory cell infiltrate. Autoantibodies directed against anagen stage hair follicle structures are a consistent finding. Observations on AA pathogenesis suggest nonhuman species can provide excellent models for the human disease. Ultimately, animal models will be used to determine the genetic basis of AA, potential endogenous and/or environmental trigger(s), mechanism(s) of disease initiation and progression, and allow rapid evaluation of new and improved disease treatments.

show abstract

“…In agreement with a previous report (Kianto et al, 1977) the present investigation showed no statistically significant difference with regard to HLA-A and -B frequencies between patients with alopecia areata totalis or universalis, and controls. Increased frequency of HLA-B12 reported by Kianto et al (1977) in focal alopecia areata, a less severe form of the disease, was however not confirmed by other authors (Kuntz et aL, 1977).…”

Section: Discussionmentioning

confidence: 63%

A study of HLA antigens and immune response to DNCB in alopecia areata

Vanneste¹,

Szapiro

Breuillard

et al. 1980

Clin Exp Dermatol

View full text Add to dashboard Cite

Summary The frequencies of 10 HLA‐A and 14 HLA‐B antigens were determined in thirty patients with alopecia areata. Distribution of HLA antigens was studied according to patient's response to a single immunizing dose of 2 mg of 1‐chloro‐2: 4‐dinitrobenzene (DNCB). HLA‐A3 was associated with defective immune response. Segregation of patients with alopecia areata into ‘high‐responders’ and ‘low‐responders’ to DNCB suggests that acquired disturbances of the immune‐response may be modulated by genes linked to the major histocompatibility complex.

show abstract

HLA antigens in alopecia areata

Cited by 14 publications

References 0 publications

Alopecia areata: an autoimmune disease?

Alopecia areata: an autoimmune disease?

Comparison of Alopecia areata in Human and Nonhuman Mammalian Species

A study of HLA antigens and immune response to DNCB in alopecia areata

Contact Info

Product

Resources

About