HLA and nasopharyngeal carcinoma in Malays

Chan, S.; Ct, Chew; Prasad, U.; Wee, G. B.; Srinivasan, Nalini; Kunaratnam, N.

doi:10.1038/bjc.1985.52

Cited by 44 publications

(23 citation statements)

References 7 publications

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“…This may suggest the probable protective role of this allele towards DHF patients in this population. However, others have documented the risk association of HLA-B*18 in Malay patients with nasopharyngeal carcinoma [40]. Furthermore, a probable protective association of HLA-B*18 allele have been reported in breast feeding infants against HIV-1 acquisition [41].…”

Section: Discussionmentioning

confidence: 99%

Susceptible and Protective HLA Class 1 Alleles against Dengue Fever and Dengue Hemorrhagic Fever Patients in a Malaysian Population

et al. 2010

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BackgroundThe human leukocyte antigen alleles have been implicated as probable genetic markers in predicting the susceptibility and/or protection to severe manifestations of dengue virus (DENV) infection. In this present study, we aimed to investigate for the first time, the genotype variants of HLA Class 1(-A and -B) of DENV infected patients against healthy individuals in Malaysia.Methodology/Principal FindingsThis study was carried out with 92 dengue disease patients and 95 healthy controls from three different ethnic groups (Malay, Chinese and Indian) in Malaysia. All patients with clinical and laboratory confirmation of DENV infection were typed for the HLA-A and B loci, using polymerase chain reaction-sequence specific primer techniques. In our total population, a significant increase for HLA-B*53 (P = 0.042, Pc = 1.008) allele and a significant decrease for A*03 (P = 0.015, Pc = 0.18, OR = 5.23, 95% CI = 1.19–23.02) and B*18 (P = 0.017, Pc = 0.408) alleles were noted in DHF patients as compared to healthy donors. We also observed that in the Malay DHF patients, allele B*13 (P = 0.049, Pc = 1.176, OR = 0.18, 95% CI = 0.03–0.90) was present at a significantly higher frequency in this population while allele HLA-B*18 (P = 0.024, Pc = 0.576) was seen to be negatively associated with DHF.Conclusions/SignificanceThese are the first findings on genetic polymorphisms in our population and we conclude that: (1) In our total population, HLA-B*53 probably involve in disease susceptibility, while the HLA-A*03 and HLA-B*18 may confer protection from progression to severe disease; (2) In the Malay population, HLA-B*13 and B*18 are probably associated in disease susceptibility and protection, respectively. These results could furnish as a valuable predictive tool to identify ethnically different individuals at risk and/or protection from severe forms of DENV infection and would provide valuable informations for the design of future dengue vaccine.

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Section: Discussionmentioning

confidence: 99%

Susceptible and Protective HLA Class 1 Alleles against Dengue Fever and Dengue Hemorrhagic Fever Patients in a Malaysian Population

et al. 2010

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“…among Singapore Chinese. and with a stronger association subsequently reported (OR=3.36, 95%CI=1.36–8.08) among Malaysians[53]. Moreover, a highly significant association was found between HLA-B18 and prevalence of NPC (OR=4.39, 95%CI=1.93–9.84) in the same Malaysian population.…”

Section: Hla Alleles Associated With Npcmentioning

confidence: 75%

“…Moreover, an association was found between HLA-A13 and the survival of patients with NPC that was also associated with a lower risk of developing the disease (OR=0.47, P<0.02). Among a total of twelve studies done subsequently in Guangdong [55], Singapore [20, 22, 29, 31, 34, 52], Taiwan [23, 32], Thailand [33], and Malaysia [53, 56], eight confirmed a significantly negative association between HLA-A11 and prevalence of NPC with an OR ranging from 0.28 to 0.55. The remaining studies consistently indicated a trend toward a low frequency of HLA-A11 in patient with NPC (Fig.…”

Section: Hla Alleles Associated With Npcmentioning

confidence: 99%

HLA Associations with Nasopharyngeal Carcinoma

Fasano²,

Wang³

et al. 2009

CMM

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Several associations have been described between the frequency of human leukocyte antigen (HLA) class I genes in certain populations and the risk of developing nasopharyngeal carcinoma (NPC). Associations between ethnic background and geographic distribution, and relative disease incidence have been reported. . Populations in geographical areas at higher risk of developing NPC display HLA distribution patterns different and sometimes opposite from areas of low incidence, whereas populations in areas with intermediate incidence display a totally independent pattern. Two main reasons may explain this association between HLA phenotype distribution and the risk of developing NPC in various populations. First, given the fact that expression of Epstein-Barr Virus (EBV) proteins by cancer cells is tightly linked with NPC development, HLA may influence the development of NPC by modulating the expression of EBV proteins. This explanation is, however, based primarily on theoretical assumptions given that no clear definition of HLA binding pattern of EBV epitopes has been directly shown to significantly alter the recognition of EBV proteins and the risk of developing the disease. Alternatively, HLA may represent a genetic marker flagging the presence of a NPC predisposition locus in close linkage disequilibrium with the HLA class I region. A critical review of known HLA associations in various geographical areas and their interpretation will be presented in this review.

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“…Another HLA antigen which is associated with NPC is B58, which occurs in both Chinese and Malay patients with NPC [23]. Patients bearing B58 are younger ( < 30 years) than those bearing A2/B46.…”

Section: Hla Haplotypesmentioning

confidence: 99%

Human Leucocyte Antigens and Nasopharyngeal Carcinoma

Ren

Chan

1996

Clinical Science

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sperm injection (ICY) of mouse oocytes with 5mM Ca++ at different intervals. Hum Reprod 1995 10: 431-5. 13. Lee KO, Oh Y, Giudice LC, Cohen P, Peehl DM, Rosenfeld RG. Identification of insulin-like growth factor binding protein (IGFBPt.3 fragments, and IGFBP-5 proteolytic activity in human seminal plasma: a comparison of normal and vasectomized patients. J Clin Endocrinol Metab 1994; 79 1367-72. 14. Homburg R, Erhel A, Abdalla HI, Jacobs HS. Growth hormone facilitates ovulation induction by gonadotrophins. Clin Endocrinol 1988; 29 113-17. 15. Lee KO, Ng SC, Lee PS, et al. The effect of growth hormone therapy on men

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HLA and nasopharyngeal carcinoma in Malays

Cited by 44 publications

References 7 publications

Susceptible and Protective HLA Class 1 Alleles against Dengue Fever and Dengue Hemorrhagic Fever Patients in a Malaysian Population

Susceptible and Protective HLA Class 1 Alleles against Dengue Fever and Dengue Hemorrhagic Fever Patients in a Malaysian Population

HLA Associations with Nasopharyngeal Carcinoma

Human Leucocyte Antigens and Nasopharyngeal Carcinoma

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