HLA and hypertrophic Hashimoto's thyroiditis in Shanghai Chinese

Wang, F. W.; Yu, Zicheng; Xy, Jin; Wang, X. L.; Zhang, D. Q.; Chen, J. L.

doi:10.1111/j.1399-0039.1988.tb01661.x

Cited by 25 publications

(17 citation statements)

References 5 publications

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“…Naito et al [29] and Onuma et al [30] reported increased allele frequencies of HLA-B46 in Japanese patients with GD, and Ito et al [31] reported increased allele frequencies of HLA-B46 in Japanese patients with HD. Similarly, Wang et al [32] and Hawkins et al [33,34] also reported an association of HLA-B46 with HD in Shanghai Chinese, Southern Chinese and Hong Kong Chinese. Chan et al [35] also reported that there is an increased allele frequency of the HLA-B46 allele in Chinese GD patients.…”

Section: Discussionmentioning

confidence: 99%

Association of HLA Alleles with Autoimmune Thyroid Disease in Korean Children

et al. 2011

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Backgrounds: Data regarding genetics of Hashimoto’s disease (HD) and Graves’ disease (GD) in Korean children are lacking. Methods: 73 patients with autoimmune thyroid disease (AITD; HD 32, GD 41) were recruited. We analyzed human leukocyte antigen (HLA) class I and HLA-DRB1 by PCR-SSP, and compared them with those of 159 controls. Results: In AITD, the allele frequencies of HLA-A*02, -B*46, -Cw*01 and -DRB1*08 were higher and those of HLA-A*30, -B*07, -Cw*07 and -DRB1*01 were lower than in controls. In HD, those of HLA-B*46 and -Cw*01 were higher and those of HLA-DRB1*01 and -Cw*07 were lower than in controls. In GD, those of HLA-A*02, -B*46, -Cw*01 and -DRB1*08 were higher and those of HLA-DRB1*07 and -Cw*07 were lower than in controls. Between HD and GD, there were no significant differences in allele frequencies. The risk of AITD in the presence of both HLA-B*46 and -Cw*01 is higher than in the presence of either allele alone. Conclusion: The susceptible and protectable alleles in HD are similar to those in GD. Coexistence of HLA-B*46 and -Cw*01 may be a genetic gene marker for early-onset AITD in Koreans.

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Section: Discussionmentioning

confidence: 99%

Association of HLA Alleles with Autoimmune Thyroid Disease in Korean Children

et al. 2011

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“…HLA-DR3, -DR4, -DR5, HLA-DQA1*0301, -DQB1*0201, and -DQB1*0301 in numerous studies of Caucasians indicate significant linkage with HT (22,26,29,(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50). In non-Caucasian ethnic groups, the reported HLA associations predisposing to HT vary distinguishingly, specifically DR9 is disease associated in Chinese (51,52), DRB1*0901-DQA1*0302-DQB1*0303 haplotype in Japanese (53,54), and DR8 in Koreans (55).…”

Section: Discussionmentioning

confidence: 99%

Major histocompatibility complex class II (DRB1, DQA1, and DQB1) and DRB104 subtypes’ associations of Hashimoto’s thyroiditis in a Greek population

et al. 2009

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Hashimoto's thyroiditis (HT) is an autoimmune disease resulting from complex interactions between genetic and environmental factors. The disease is associated with certain human leukocyte antigen (HLA) class II alleles in various populations. We aimed to determine in this study, for the first time in a Greek population, the association of HLA-DRB1*, -DQA1*, and -DQB1* alleles with HT. HLA-DRB1*, -DQA1*, and -DQB1* alleles' and -DRB1*04 subtypes' distribution was evaluated in 125 patients with HT and in 500 healthy control individuals by using a DNA-based sequence-specific primer method. Chi(_)squared tests and Bonferroni correction method were applied in the statistical analysis of the data. Significantly higher frequency of DRB1*04 (24.8% vs 7.7%, P < 0.0001) was observed in HT patients, while HLA-DRB1*07 was significantly decreased (2.8% vs 7.9%, P < 0.05). HLA-DRB1*04 subtyping showed a significant increase of DRB1*0405 (21% vs 7.8%, P < 0.0001) in HT patients. Also significant high frequencies of DQB1*0201 (14.8% vs 8.2%, P < 0.001), DQB1*0302 (18.8% vs 7.0%, P < 0.0001), and DQA1*0301 (25.6% vs 7.8%, P < 0.0001) were recorded in the patient group. Conducting the first research of this kind in a Greek population, our study tries to provide an evaluation of the prevalence of HT relating to HLA-DRB1*0405, and we report a relative risk of 2.7 for HT in a Greek population.

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“…HLA-Bw46 and -DR9 are associated with HT in Chinese patients, while the supertypic specificity HLA-DRw53 is associated in Japanese, the relative risk conferred by HLA-DR9 being much less (129)(130)(131). HLA-Bw46 and -DR9 are associated with HT in Chinese patients, while the supertypic specificity HLA-DRw53 is associated in Japanese, the relative risk conferred by HLA-DR9 being much less (129)(130)(131).…”

Section: Immunogeneticsmentioning

confidence: 96%

Autoimmune Thyroid Disease: Further Developments in Our Understanding*

1994

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The revolution in molecular techniques has allowed dissection of the autoimmune response in a way impossible to imagine 10 yr ago. There have been spectacular advances in our understanding of self-tolerance mechanisms and how these may fail, combined with a detailed comprehension of antigen presentation, functional T cell subsets, and TCR utilization in autoimmunity, albeit usually in animal models that resemble, but do not exactly duplicate, human diseases. More gradually, these findings are being translated to thyroid autoimmunity, where the major achievement of the last decade has been the molecular characterization of the three main thyroid autoantigens. This in turn has allowed epitope identification, although again the only clear data so far have come from animal models of EAT. Another advance has been the recognition that the thyrocyte is not a helpless target of autoaggression, being capable of expressing a wide array of immunologically active molecules, which may exacerbate or diminish the autoimmune response. In 1983, there was considerable excitement at the discovery of the first of these phenomena, namely MHC class II expression, but its possible role in autoantigen presentation remains to be defined. By analogy with pancreatic beta-cells, and based on our own data, we believe that class II-expressing thyrocytes have little, if any, such role and suspect that instead this may be a mechanism for inducing peripheral tolerance. Defining the contribution of thyrocytes to the intrathyroidal autoimmune response, whether from released cytokines or surface-bound molecules, will be crucial to our future understanding, as well as holding the promise that these thyroid-derived products might be therapeutic targets. Despite molecular developments in HLA analysis, there have been no really major improvements in our understanding of the immunogenetics of thyroid autoimmunity, equivalent to those made in type 1 diabetes mellitus. The available data suggest strongly that non-MHC genes play an important role in susceptibility, and novel approaches will be required to identify these. On the other hand, we know more about the importance of environmental and endogenous (most probably hormonal) factors in thyroid autoimmunity. Understanding the basic immunological changes in the postpartum period is still poor, however, as most studies to date have concentrated on epidemiology and clinical delineation. As PPTD undergoes spontaneous remission, elucidation of these mechanisms has clear implications for treatment.(ABSTRACT TRUNCATED AT 400 WORDS)

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HLA and hypertrophic Hashimoto's thyroiditis in Shanghai Chinese

Cited by 25 publications

References 5 publications

Association of HLA Alleles with Autoimmune Thyroid Disease in Korean Children

Association of HLA Alleles with Autoimmune Thyroid Disease in Korean Children

Major histocompatibility complex class II (DRB1, DQA1, and DQB1) and DRB104 subtypes’ associations of Hashimoto’s thyroiditis in a Greek population

Autoimmune Thyroid Disease: Further Developments in Our Understanding*

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HLA and hypertrophic Hashimoto's thyroiditis in Shanghai Chinese

Cited by 25 publications

References 5 publications

Association of HLA Alleles with Autoimmune Thyroid Disease in Korean Children

Association of HLA Alleles with Autoimmune Thyroid Disease in Korean Children

Major histocompatibility complex class II (DRB1*, DQA1*, and DQB1*) and DRB1*04 subtypes’ associations of Hashimoto’s thyroiditis in a Greek population

Autoimmune Thyroid Disease: Further Developments in Our Understanding*

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Major histocompatibility complex class II (DRB1, DQA1, and DQB1) and DRB104 subtypes’ associations of Hashimoto’s thyroiditis in a Greek population