HLA alleles, IFN-γ responses to HPV-11 E6, and disease severity in patients with recurrent respiratory papillomatosis

Bonagura, Vincent R.; Vambutas, Andrea; DeVoti, James; Rosenthal, David W.; Steinberg, Bettie M.; Abramson, Allan L.; Shikowitz, Mark J.; Gjertson, David W.; Reed, Elaine F.

doi:10.1016/j.humimm.2004.05.014

Cited by 55 publications

(83 citation statements)

References 33 publications

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“…Patients were genotyped for HLA-DRB1 using polymerase chain reaction (PCR) techniques followed by hybridization with sequence-specific oligonucleotide probes using reagents purchased from One Lambda (Canoga Park, CA). High-resolution typing of DRB1 was accomplished using a typing strategy of group-specific amplification of exon 2, followed by direct sequencing of PCR products, as previously described (51). PCR products were purified using ExoSAP-IT (USB, Cleveland, OH) treatment and were used as a template for direct sequencing.…”

Section: Methodsmentioning

confidence: 99%

“…Sequence analysis was performed using Matchmaker allele identification software (Applied Biosystems). Ambiguous allele combinations were resolved using 3Ј amplification primers specific for the dimorphic sequences at codon 86 (GTG/GGT), followed by sequence-based typing as previously described (51). The SE was defined as the presence of any 1 of the following: DRB1*0101, *0102, *0401, *0404, *0405, *0408, *0410, *1001, *1402, or *1406.…”

Section: Methodsmentioning

confidence: 99%

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Association of tumor necrosis factor α polymorphism, but not the shared epitope, with increased radiographic progression in a seropositive rheumatoid arthritis inception cohort

Khanna

Park

et al. 2006

Arthritis & Rheumatism

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Objective. To determine whether the tumor necrosis factor ␣ (TNFA) -308 guanine-to-adenosine polymorphism and/or the shared epitope (SE) is associated with radiographic damage in patients with early rheumatoid arthritis (RA).Methods. The cohort consisted of 189 patients with early seropositive RA (median 5.6 months since symptom onset) who had active disease, no previous disease-modifying antirheumatic drug treatment, and >2 sets of scored radiographs of the hands/wrists and forefeet. TNFA -308 polymorphism was analyzed by polymerase chain reaction pyrosequencing. The SE was defined as presence of any 1 of the following HLA-DRB1 alleles: *0101, *0102, *0401, *0404, *0405, *0408, *0410, *1001, *1402, or *1406. Radiographic progression was assessed by the total Sharp score.Results. Using a weighted least-squares regression analysis, patients with the -308 TNFA AA plus AG genotypes (n ‫؍‬ 49) had significantly higher rates of progression in erosion scores (median 0.84 versus 0.48 units/year), joint space narrowing (JSN) scores (0.42 versus 0.04), and total Sharp scores (1.70 versus 0.61) compared with patients with the TNFA GG genotype (n ‫؍‬ 140). Presence of the SE (n ‫؍‬ 137) was associated with significantly lower progression rates (per year) for total Sharp scores (median 0.9 versus 1.25 units/year) and JSN scores (0.04 versus 0.41), but not for erosion scores (0.50 versus 0.61) compared with patients without the SE (n ‫؍‬ 52). In a least-squares multiple linear regression model, the presence of the AA plus AG genotypes was associated with a significantly higher progression rate after adjusting for the presence of the SE, interaction between the SE and the AA plus AG genotypes, baseline log C-reactive protein level, Health Assessment Questionnaire Disability Index, total Sharp score, swollen joint count, and presence of osteophytes (osteoarthritis). There was a strong linkage disequili-

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Association of tumor necrosis factor α polymorphism, but not the shared epitope, with increased radiographic progression in a seropositive rheumatoid arthritis inception cohort

Khanna

Park

et al. 2006

Arthritis & Rheumatism

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“…This same study found preliminary evidences for an HLA-DRB1*14 association in juvenileonset disease and a HLA-B*27 association in adult-onset disease [135] . Another study confirmed the association between HLA-DRB1*03: 01 and the severity of the disease in Caucasian patients and found also a positive association with DRB1*01: 02, DQB1*02: 01 and DQB1*02: 02 and a protective effect for DQB1*06: 02 [136] . In Korean patients HLA-DRB1*11: 01 and -DQB1*03: 01, together with DRB1*11: 01-DQB1*03: 01 haplotype, were strongly associated to severe RRP [137] .…”

Section: Recurrent Respiratory Papillomatosismentioning

confidence: 62%

HLA Loci and Respiratory Infectious Diseases

Spínola

2016

Journal of Respiratory Research

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The HLA system harbour a wide set of genes that plays an important role in the regulation and action of the immune system against invading pathogens, making them natural candidates for research on the genetic susceptibility for respiratory infections. Thus, along past decades, this topic has been subject to intense research and, consequently, several alleles of those loci have been implicated in the ability, more or less effective, to tackle and control invading pathogens in the respiratory system. Current editorial introduce, revise, summarize and comment the major advances in the role of HLA genes for the development of, and protection against, respiratory infectious disease. A general picture is drawn and new challenges on the field are relocated, especially those that might enlighten respiratory diseases aetiology and, thus, contribute in advances for diagnosis and treatment.

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“…On the other hand, the HLA-DQB1*0602 allele was more frequent in controls than in Caucasians with severe disease, suggesting a control effect of the severity by that allele. While DQB1*0602 was absent, the DQB1*0201 and DQB1*0202 alleles showed increased frequency in African Americans 9 . More recently, only results indicating a potential protective role for DQB1*0602 could be replicated by Rodier C. et al (eleven).…”

Section: Discussionmentioning

confidence: 89%

“…However, it is still unclear whether HPV causes this alteration in immunity or if children with impaired immunity develop RRP. As well as the susceptibility to cervical cancer caused by HPV has been related to some specific HLA alleles, similarly it has been seen that this association is fulfilled in patients with RRP, where certain alleles influence the course of the disease, favoring the severity [8][9][10] or, on the contrary, fulfilling a protective role 11,12 .…”

Section: Introductionmentioning

confidence: 88%

Papilomatosis respiratoria recurrente en paciente pediátrico: reporte de un caso

Benavente

Contreras

Perferi

et al. 2017

Rev. chil. pediatr.

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Introduction: Genetic variability related to the host immune system has been proposed as one of the most influential factors in the development of diseases caused by HPV. Clinical case: We report the case of a 5-year-old child in whom chronic laryngeal papillomatosis, probably acquired vertically during labor, was detected. The diagnosis of laryngeal papillomatosis was confirmed with a biopsy after a first surgery to remove the papillomas. The Derkay classification system was used to assess the severity of papillomatosis. Biopsy genotyping was performed by demonstrating HPV-6. Later, HLAD-QA1*0505, -DQB1*0301, -DRB1*1101 alleles were homozygous for HLA allele typing. Conclusions: Further studies are needed to identify the most prevalent HLA alleles in the Latino population and their potential association with genetic susceptibility in Recurrent Respiratory Papillomatosis.

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HLA alleles, IFN-γ responses to HPV-11 E6, and disease severity in patients with recurrent respiratory papillomatosis

Cited by 55 publications

References 33 publications

Association of tumor necrosis factor α polymorphism, but not the shared epitope, with increased radiographic progression in a seropositive rheumatoid arthritis inception cohort

Association of tumor necrosis factor α polymorphism, but not the shared epitope, with increased radiographic progression in a seropositive rheumatoid arthritis inception cohort

HLA Loci and Respiratory Infectious Diseases

Papilomatosis respiratoria recurrente en paciente pediátrico: reporte de un caso

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