HLA-A, -B, -DR and -DQ allele and haplotype frequencies in the Moroccan population: a general population study

Brick, C.; Bennani, N.; Atouf, O.; Essakalli, M.

doi:10.1016/j.tracli.2006.12.003

Cited by 21 publications

(29 citation statements)

References 16 publications

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“…Distribution of alleles and haplotypes observed in our controls are in accordance with previous Moroccan studies (Brick et al, 2006;Oumhani et al, 2002;Canosi at al., 2010). Our data confirm the well-known positive association between T1D and HLA-DRB1*03 and -DRB*04.…”

Section: Discussionsupporting

confidence: 92%

Human leukocyte antigen (HLA) polymorphism and type 1 diabetes in the Moroccan population

Benseffaj¹,

Brick²,

Atouf³

et al. 2012

Afr. J. Biotechnol.

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Insulin-dependent diabetes mellitus or type 1 diabetes is an autoimmune multifactorial disease which has a great socio-economic impact. In Morocco, less is known about the contribution of Human leukocyte antigen (HLA) alleles to type 1 diabetes susceptibility. Our study focused on evaluating the distribution of class II HLA genes among Moroccan patients presenting type 1 diabetes coming from different regions of the country. A total of 76 patients diagnosed with type I diabetes were compared to a group of 248 healthy controls matched by age, sex, and ethnic origin. The HLA class II (DR and DQ) typing of patients and controls was performed using polymerase chain reaction sequence-specific primers (PCR-SSP). Ambiguous typings were reanalyzed by Luminex technology. We found a significant association between HLA-DRB1*03 (p = 0.0001), DRB1*04 (p = 0.0001), DQB1*02 (p = 0.0001, OR = 4.4) and DQB1*03 (p = 0.002) alleles frequencies and the susceptibility to diabetes. The HLA-DQB1*06 allele was significantly decreased in patients (p = 0.008). DRB1*03-DQB1*02, DRB1*04-DQB1*03 and DRB1*04-DQB1*02 haplotypes induce susceptibility to type 1 diabetes while DRB1*13-DQB1*06 and DRB1*15-DQB1*06 haplotypes seems to confer a protective effect in our population. These data highlights that Moroccans diabetic patients do share a series of traits with diabetics of other origins but also have specific characteristics.

show abstract

Section: Discussionsupporting

confidence: 92%

Human leukocyte antigen (HLA) polymorphism and type 1 diabetes in the Moroccan population

Benseffaj¹,

Brick²,

Atouf³

et al. 2012

Afr. J. Biotechnol.

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show abstract

“…This value is also highest in other Mediterranean and African populations [12,13,23,[24][25][26][27][28][29][30]. HLA-A ⁄ 01 (11.4%) has a similar distribution to those reported in Moroccan (12.1%) [12,31,32], and Algerian (11.9%) [14] and other populations [32] and Tunisians (17.5%) [34] but lower than those reported for Tunisian Berbers (24.8%) [39]. Similar frequencies were also found for the allele HLA-A ⁄ 01:01:01:01 (11.4%) in Tunisians (11.2%) [34] and Moroccans (12.8%) [32].…”

Section: Hla Allele Frequenciesmentioning

confidence: 66%

“…The highest frequencies of HLA-B alleles was found in allelic group HLA-B ⁄ 50 (16.1%) followed by B ⁄ 51 (11.0%) and B ⁄ 35 (10.2%). HLA-B ⁄ 50 showed higher frequencies compared to other Mediterranean populations [12,14,23,27,31,40]; this allele is commonly observed in Arab populations [14,23,31], and in Tunisian Berbers (15.7%) [39]. HLA-B ⁄ 51, common in Mediterranean populations [23,33], is significantly higher in the Cyrenaica population (p < 0.05) than Tunisian Berbers (2.9%) [39].…”

Section: Hla Allele Frequenciesmentioning

confidence: 79%

“…For HLA-A/HLA-B, two haplotypes presented a frequency higher than 2%: A ⁄ 02:01:01:01-B ⁄ 07:02:01 and A ⁄ 23: 01:01-B ⁄ 50:01:01 (both 2.97%). These haplotypes were found to be most frequent in Moroccans (HF: 1.59%) [12] and Tunisians (HF: 6.7%) [33].…”

Section: Hla-a -B and -Drb1 Haplotype Frequencymentioning

confidence: 96%

“…HLA polymorphism in the Libyan population has not been investigated previously. Until recently, HLA class I and II allele distributions in North Africa were available only for Tunisia, Algeria and Morocco [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

HLA-A, -B and -DRB1 allele frequencies in Cyrenaica population (Libya) and genetic relationships with other populations

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Association of HLA-DR/DQ polymorphism with myasthenia gravis in Tunisian patients

Fekih-Mrissa

Klai

Zaouali

et al. 2013

Clinical Neurology and Neurosurgery

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HLA-A, -B, -DR and -DQ allele and haplotype frequencies in the Moroccan population: a general population study

Cited by 21 publications

References 16 publications

Human leukocyte antigen (HLA) polymorphism and type 1 diabetes in the Moroccan population

Human leukocyte antigen (HLA) polymorphism and type 1 diabetes in the Moroccan population

HLA-A, -B and -DRB1 allele frequencies in Cyrenaica population (Libya) and genetic relationships with other populations

Association of HLA-DR/DQ polymorphism with myasthenia gravis in Tunisian patients

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