HIV, TB, inflammation and other correlates of serum phosphate: A cross-sectional study

Friis, Henrik; Range, Nyagosya; Changalucha, John; PrayGod, George; Jeremiah, Kidola; Faurholt‐Jepsen, Daniel; Krarup, Henrik; Andersen, Anita Sylvest; Kæstel, Pernille; Filteau, Suzanne

doi:10.1016/j.clnesp.2018.07.003

Cited by 4 publications

(1 citation statement)

References 19 publications

(21 reference statements)

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“…After the mid-1990s, many patients with dual infection of MTB and human immunodeficiency virus appeared in all countries in the world. Therefore, the normalized prevention and control of TB combined with HIV dual infection (TB/HIV) must be carried out seriously (8,9).…”

Section: Introductionmentioning

confidence: 99%

Influence of Dexmedetomidine on Cognitive Function and Inflammatory Factors in Rats and Analysis of Its Molecular Mechanism after Cardiac Surgery under Cardiopulmonary Bypass

Yang

Zheng

Zhang

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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The study aimed to explore the influence of Dexmedetomidine (Dex) on cognitive function and inflammatory factors in rats after cardiac surgery under cardiopulmonary bypass (CPB). For this purpose, 30 healthy male SD rats were reared in a quiet and clean environment with alternating light for 12 hours. They were rolled randomly into 3 groups, each with 10 rats, namely the control (Ctrl) group, the experimental group, and the Dex group. The rats in the Ctrl were not treated, and the rats in the experimental group were intraperitoneally injected with 50μg/kg saline. After that, cardiac surgery was performed under CPB. Rats in the Dex group were injected with 50 μg/kg Dex intraperitoneally and underwent cardiac surgery under CPB. The Morris water maze (MWM) experiment was performed to test the learning and memory abilities and spatial positioning abilities of SD rats. Enzyme-linked immunosorbent assay (ELISA method) was adopted to detect the contents of TNF-α, IL-6, and IL-1β. Fluorescence quantitative PCR was applied to determine the mRNA expression levels of TNF-α, IL-6, and IL-1β in the hippocampus. Results showed that in the MWM experiment, in contrast with the Ctrl, the escape latency of the experimental group and the Dex group after surgery were prolonged (P<0.05), and the times they crossed platforms reduced (P<0.05). In contrast with the experimental group, the escape latency of the Dex group shortened, and the times they crossed platforms increased. ELISA suggested that in contrast with the experimental group, the concentrations of TNF-α, IL-6, and IL-1β in the Ctrl decreased (P<0.05), and those in the Dex group decreased slightly. In the fluorescence quantitative PCR experiment, in contrast with the experimental group, the mRNA expression levels of TNF-α, IL-6, and IL-1β in the Ctrl increased, and those in the Dex group decreased slightly. Then Dex can improve the cognitive dysfunction of rats undergoing cardiac surgery under CPB, and its molecular mechanism may be to reduce the inflammation around the heart and hippocampus.

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Section: Introductionmentioning

confidence: 99%

Influence of Dexmedetomidine on Cognitive Function and Inflammatory Factors in Rats and Analysis of Its Molecular Mechanism after Cardiac Surgery under Cardiopulmonary Bypass

Yang

Zheng

Zhang

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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Refeeding syndrome occurs among older adults regardless of refeeding rates: A systematic review

et al. 2021

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Serum calcium and phosphorus levels in patients of HIV positive under the treatment

Kiran¹,

Kanth²,

Satyannarayana³

et al. 2020

IJCBR

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The abnormal levels of serum calcium and phosphorus are mostly seen in diseases of bone, kidney, tuberculosis, parathyroid diseases etc. The present study is aimed to measure the serum total calcium and phosphorous levels in HIV infected patients and in healthy controls. This cross sectional case-control study was conducted at Department of Biochemistry, NRI Medical College and General Hospital, Chinnakakani, Guntur, AndhraPradesh. A total of 90 HIV positive patients were taken as cases and 90 healthy subjects served as controls. Patients with congestive heart failure, liver diseases, diabetes and hypertension were excluded from the study. Seropositivity of all 90 HIV patients was confirmed by HIV TRI-DOT test. 5 ml of venous blood sample was collected after taking aseptic precautions from the study subjects. Serum was used for theestimation of Calciumby O-Cresolphthalein complexone method and Phosphorus by Fiske and Subbarow Method.In this study, HIV positive patients had significantly reduced mean serum calcium (8.02±0.86 mg/dl) and phosphorous (2.68±0.65 mg/dl) levels compared with healthy subjects. The present study may conclude that serum levels of calcium and phosphorus were decreased in HIV positive patients, suggesting that the levels of calcium and phosphorous should be closely monitored.

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HIV, TB, inflammation and other correlates of serum phosphate: A cross-sectional study

Abstract: While HIV and TB are associated with higher serum phosphate, our data suggest that TB treatment is followed by transient reductions in serum phosphate, which may reflect hypophosphataemia in some patients.

Cited by 4 publications

References 19 publications

Influence of Dexmedetomidine on Cognitive Function and Inflammatory Factors in Rats and Analysis of Its Molecular Mechanism after Cardiac Surgery under Cardiopulmonary Bypass

Influence of Dexmedetomidine on Cognitive Function and Inflammatory Factors in Rats and Analysis of Its Molecular Mechanism after Cardiac Surgery under Cardiopulmonary Bypass

Refeeding syndrome occurs among older adults regardless of refeeding rates: A systematic review

Serum calcium and phosphorus levels in patients of HIV positive under the treatment

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