HIV Related High Risk Behaviors and Willingness to Participate in HIV Vaccine Trials among China MSM by Computer Assisted Self-Interviewing Survey

Abstract

Background. The number of new HIV infections among MSM of China is rapidly increasing in recent years and behavioral interventions have had limited effectiveness. To control the HIV pandemic may lie in an HIV vaccine. This study examined the factors associated with willingness to participate (WTP) in HIV vaccine clinical trials among China MSM. Methods. A cross-sectional survey was carried out among MSM from three cities in northeast China. Questionnaires pertaining to MSM risk behavior and WTP in HIV vaccine trials were administered through computer assisted self-interviewing (CASI). Results. A total of 626 MSM participated in this survey. 54.8% had occasional male partners and 52.2% always used condoms with male sex partners. HIV prevalence was 5.0%. 76.7% were WTP in a preventive HIV vaccine clinical trial. Results showed that HIV vaccination is a means of protection for spouses and family; family support to participate in vaccine trials and desire for economic incentives were significantly associated with WTP. Conclusions. There was a high proportion of WTP in HIV vaccine trials among Chinese MSM. The high HIV prevalence and high proportion of risky sexual behavior indicate that Liaoning MSM are potential candidates for HIV vaccine trials.

The willingness to participate in biomedical research involving human beings in low‐ and middle‐income countries: a systematic review

“…Additional reasons for participation mentioned were: ability to withdraw , advice from physician , community involvement , cultural acceptability , creating a feeling of community , low pressure decision , need for treatment , research involving a non‐invasive procedure , peer enrolment , low perception of risk , result availability , guarantee of confidentiality , being unaware of voluntariness of participation , research outcome, and finally seeing research participation as motivation to avoid risky behaviour .…”

“…Additional reasons for participation mentioned were: ability to withdraw [91], advice from physician [20,27,77,85], community involvement [34,[61][62][63]66], cultural acceptability [63,91], creating a feeling of community [44], low pressure decision [75], need for treatment [77], research involving a non-invasive procedure [46,81], peer enrolment [33,44,84], low perception of risk [54,70], result availability [20], guarantee of confidentiality [23,33,34,62], being unaware of voluntariness of participation [46], research outcome, [60,62,66,84] and finally seeing research participation as motivation to avoid risky behaviour [59]. The most important reasons for non-participation were safety concerns, inconvenience, stigmatisation, lack of social support, confidentiality concerns, physical pain, efficacy concerns and distrust.…”

“…Despite being ranked third overall, stigmatisation was consistently ranked higher for HIV research, specifically in Sub-Saharan Africa and Asia, among non-patients, and female participants. Stigmatisation was in fact only mentioned once in relation to non-HIV research, suggesting that despite being mentioned 20 times overall [22,23,31,32,36,37,41,42,47,50,52,53,68,69,75,86,93,94,98,107], being ranked in the top 35 times [23,32,41,50,94], and as the top reasons thrice [23,41,50], it is not one of the more important reasons for non-participation when looking at human subjects research in general.…”

Patient-Centered Practices for Engaging Transgender and Gender Diverse Patients in Clinical Research Studies

“…Research into barriers and facilitators to participating in research has been conducted in other marginalized populations, such as people living with HIV (27)(28)(29), men who have sex with men (MSM) (30)(31)(32)(33)(34)(35) racial and ethnic minorities (32,36,37) and people who use drugs (32,37). Common barriers to participating in research for these groups have included: 1.…”

“…Believing the research could bene t participants and/or society/ altruism (31,32,37,39,42,43,45), 3. Financial incentive (31,32,34,37,39,46), 4. Opportunity to build and/or be part of a community (32), 5.…”