2002
DOI: 10.1590/s0074-02762002000200001
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HIV-1 Polymorphism: a Challenge for Vaccine Development - A Review

Abstract: The perspective for the development of anti-HIV/AIDS vaccines became a target sought by several research groups and pharmaceutical companies. However, the complex virus biology in addition to a striking genetic variability and the limited understanding of the immunological correlates of protection have made this an enormous scientific challenge not overcome so far. In this review we presented an updating of HIV-1 subtypes and recombinant viruses circulating in South American countries, focusing mainly on Brazi… Show more

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Cited by 35 publications
(42 citation statements)
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“…We found a predominance of subtype B (94%), which is similar to those found in previous evaluations of samples from the Southeast and Northeast regions of Brazil (reviewed by Morgado et al 2002). In the present study we identified the presence of HIV-1 subtype F (2.7%) and B/ F (2.7%) in Ceará for the first time.…”
Section: Discussionsupporting
confidence: 91%
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“…We found a predominance of subtype B (94%), which is similar to those found in previous evaluations of samples from the Southeast and Northeast regions of Brazil (reviewed by Morgado et al 2002). In the present study we identified the presence of HIV-1 subtype F (2.7%) and B/ F (2.7%) in Ceará for the first time.…”
Section: Discussionsupporting
confidence: 91%
“…In addition, subtype C was not detected in any of our patients, which shows that the distribution of the HIV-1 genetic subtypes assumes currently different patterns in different regions of the country (Morgado et al 2002).…”
Section: Discussionmentioning
confidence: 55%
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“…Recently however, the number of non-B and recombinant HIV isolates reported increased significantly (reviewed by Morgado et al 2002). Most studies conducted in Brazil to evaluate the HIV diversity have been carried out using samples from the Southeastern region, mainly from the states of Rio de Janeiro and São Paulo.…”
mentioning
confidence: 99%