History of vascular reactivity models and their involvement in                     hypertension pathogenesis

Conceição-Vertamatti, Ana Gabriela; Borghi, Filipy; Canova, Fernando; Kassisse, Dora Maria Grassi

doi:10.1024/0301-1526/a000659

Cited by 7 publications

(7 citation statements)

References 57 publications

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“…[5][6][7] Animal models are critical to advancements in medical research and provide valuable information regarding many aspects of the disease. [8][9][10] Classically, there are two well established models of sympathetic overactivity: the NG-monomethyl-L-arginine methyl ester (L-NAME)-induced hypertension and the spontaneously hypertensive rats (SHR). 10 Hypertensive condition can lead to abnormalities in cardiac structure, and consequent dysfunction in cardiac electrical activity.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] Classically, there are two well established models of sympathetic overactivity: the NG-monomethyl-L-arginine methyl ester (L-NAME)-induced hypertension and the spontaneously hypertensive rats (SHR). 10 Hypertensive condition can lead to abnormalities in cardiac structure, and consequent dysfunction in cardiac electrical activity. 11,12 The electrocardiogram (ECG) is a recording of the electrical activity of the heart and widely used to diagnose and detect heart problems.…”

Section: Introductionmentioning

confidence: 99%

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Electrocardiographic Abnormalities in Hypertension Models

Conceição-Vertamatti

Borghi

Ishizu

et al. 2019

IJCS

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Background: Hypertensive condition can lead to abnormalities in heart structure and electrical activity. The electrocardiogram (ECG) is a recording of the electrical activity of the heart and widely used to diagnose and detect heart problem. Objective: We conducted a comparative ECG analysis between two hypertension models (L-NAME and SHR) and their controls (Wistar and Wistar-Kyoto) at six and 15 th week of age. Methods: Blood pressure was measured at the end of the 15 th week, and electrocardiography was performed at six and 15 weeks of age in anaesthetized rats. Data normality was confirmed by Kolmogorov-Smirnov test followed by unpaired Student's t-test and the Mann-Whitney for parametric and non-parametric data, respectively. Results are expressed as mean ± SD. The accepted level of significance was set at p < 0.05. Results: L-NAME exhibited prolongation of JT and QT intervals and SHR showed a decrease in heart rate when compared to Wistar-Kyoto and L-NAME. Wistar-Kyoto exhibited short PR interval with increased QRS complex, and only QT prolongation at 15 weeks compared to Wistar. Conclusions: All the hypertension models used in this study featured an increase in blood pressure. However, while SHR showed cardiac dysfunction, L-NAME exhibited changes in ventricular performance. These results may guide future studies on different types and models of hypertension.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrocardiographic Abnormalities in Hypertension Models

Conceição-Vertamatti

Borghi

Ishizu

et al. 2019

IJCS

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“…Complex mechanisms are involved in the pathogenesis of HT. In the light of studies performed to date, neurohormonal mechanisms, such as sympathetic nervous system activation and renin‐angiotensin‐aldosterone symptom activation, together with vascular reactivity and insulin resistance, have been implicated in the pathogenesis of primary HT . There has also been a recent increase in studies involving the genetics of primary HT, and abnormal expression of some genes has been linked to its development.…”

Section: Introductionmentioning

confidence: 99%

Down‐regulation of miRNA 145 and up‐regulation of miRNA 4516 may be associated with primary hypertension

Özkan

Ulusoy

Geyik³

et al. 2019

J of Clinical Hypertension

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Complex mechanisms including genetic factors have been proposed in the pathogenesis of primary hypertension (HT). Micro RNAs (miRNAs) are single‐stranded RNA molecules that are not converted into protein products. However, it has been established that genes regulate conversion into protein products. The primary aim of this study was to investigate the roles of miRNA 4516, miRNA 145, miRNA 24, and miRNA 181a in the pathogenesis of HT. The secondary aim was to investigate the relation between these miRNAs and renin, aldosterone, norepinephrine, renalase, and NOS. Fifty‐two hypertensive and 51 control normotensive individuals under observation in the Cappadocia cohort were included in the study. miRNA 4516, miRNA 181a, miRNA 24, and miRNA 145 levels were measured using the ddPCR method. miRNA 4516 and norepinephrine levels were significantly higher in the HT group (P < .005 for both), while miRNA 145 levels were significantly lower (<.05). miRNA 4516 up‐regulation (P < .05) and miRNA 145 down‐regulation (P < .05) were identified as independent predictors of HT. Renalase exhibited negative correlation with miRNA 4516 and positive correlation with miRNA 145 in the patient and control group. In addition, negative correlation was present between miRNA 24 and NE and NOS and between miRNA 181a and NOS in the patient group. Our study identified, for the first time in the literature, miRNA 4516 up‐regulation and miRNA 145 down‐regulation as independent determinants of HT. Further studies performed in the light of our findings may lead to a better understanding of the pathogenesis and new therapeutic possibilities.

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“…The in vivo study of the hypotensive properties of mousse samples was performed on 14-week-old male spontaneously hypertensive rats (SHRs) [30] (Puschino Kennel of Laboratory Animals, Pushchino, Russia). At the beginning of the experiment, the rats' body weight was 280 ± 20 g. The systolic blood pressure (SBP) and the diastolic blood pressure (DBP) were 184 ± 15 mmHg and 112 ± 14 mmHg, respectively, which corresponds to the typical SBP and DBP in SHRs of this age group [31].…”

Section: Assay Of Antihypertensive Effect In Spontaneously Hypertensimentioning

confidence: 96%

“…One of the most useful animal models currently used to evaluate the antihypertensive effect in vivo is SHRs. For many years, SHRs were used as an animal model of essential (primary) hypertension and cardiovascular diseases [31].…”

Section: In Vivo Hypotensive Properties Of Mousse Samplesmentioning

confidence: 99%

Whey Protein Hydrolysate and Pumpkin Pectin as Nutraceutical and Prebiotic Components in a Functional Mousse with Antihypertensive and Bifidogenic Properties

et al. 2019

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Systematical consumption of functional products has a significant positive effect on health and can reduce the risk of diseases. The aim of this study was to investigate the possibility of using whey protein hydrolysate (WPH) and pumpkin pectin as ingredients in a functional mousse, to evaluate the mousse’s antioxidant and hypotensive activities in vitro, and to evaluate the effect of the long-term intake of mousse samples on the progression of hypertension in spontaneously hypertensive rats (SHRs) and on the microbiome status in Wistar rats with antibiotic-induced dysbiosis. The experimental mousse’s in vitro antioxidant activity (oxygen radical absorbance capacity) increased by 1.2 times. The hypotensive (angiotensin-1-converting enzyme inhibitory) activity increased by 6 times in comparison with a commercial mousse. Moreover, the addition of pectin allowed the elimination of the bitter aftertaste of WPH. In vivo testing confirmed the hypotensive properties of the experimental mousse. The systolic blood pressure in SHRs decreased by 18 mmHg and diastolic blood pressure by 12 mmHg. The experimental mousse also showed a pronounced bifidogenic effect. The Bifidobacterium spp. population increased by 3.7 times in rats orally administered with the experimental mousse. The results of these studies confirm that WPH and pumpkin pectin are prospective ingredients for the development of functional mousses.

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History of vascular reactivity models and their involvement in hypertension pathogenesis

Cited by 7 publications

References 57 publications

Electrocardiographic Abnormalities in Hypertension Models

Electrocardiographic Abnormalities in Hypertension Models

Down‐regulation of miRNA 145 and up‐regulation of miRNA 4516 may be associated with primary hypertension

Whey Protein Hydrolysate and Pumpkin Pectin as Nutraceutical and Prebiotic Components in a Functional Mousse with Antihypertensive and Bifidogenic Properties

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