2019
DOI: 10.1038/s41392-019-0063-8
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Abstract: Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its main pathological features are cerebral atrophy, amyloid plaques, and neurofibrillary tangles in the brains of patients. There are various descriptive hypotheses regarding the causes of AD, including the cholinergic hypothesis, amyloid hypothesis, tau propagation hypothesis, mitochondrial cascade hypothesis, calcium homeostasis hypo… Show more

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Cited by 398 publications
(314 citation statements)
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References 459 publications
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“…Among the different forms of dementia, Alzheimer's disease (AD) is the most common (60-70% of cases) and currently affects 47 million people worldwide [5][6][7]. Its prevalence rises exponentially with age and, due to increasing lifespan, it has been predicted to double every 20 years, causing a huge burden on healthcare costs [5,8]. AD is characterized by irreversible and progressive brain atrophy, loss of memory, and cognition.…”
Section: Introductionmentioning
confidence: 99%
“…Among the different forms of dementia, Alzheimer's disease (AD) is the most common (60-70% of cases) and currently affects 47 million people worldwide [5][6][7]. Its prevalence rises exponentially with age and, due to increasing lifespan, it has been predicted to double every 20 years, causing a huge burden on healthcare costs [5,8]. AD is characterized by irreversible and progressive brain atrophy, loss of memory, and cognition.…”
Section: Introductionmentioning
confidence: 99%
“…Amyloid-β plaque deposition, albeit slight controversy, is still to this day considered the main pathology of AD [3,[71][72][73]. Reduction in Aβ plaques in transgenic mouse models were regarded as an endpoint for the studies of AD [74,75].…”
Section: Discussionmentioning
confidence: 99%
“…Many hypotheses have been proposed to underlie the development of AD, including i) amyloid beta aggregation, ii) tau hyperphosphorylation, iii) neuroinflammation, iv) neurotransmitter dysfunction, v) mitochondria dysfunction, vi) glucose metabolism, vii) vascular dysfunction and viii) viral infection [214][215][216][217] . These hypotheses have generated many new compounds, none of which showed efficacy in slowing cognitive decline or improving global functioning 214,216 . Arc appears a good therapeutic candidate for AD, because of its involvement in amyloid beta production, tau phosphorylation, neuroinflammation and neurotransmission.…”
Section: Arc Controls Synaptic Plasticity and Intrinsic Excitabilitymentioning
confidence: 99%