Histórico das hepatites virais

Fonseca, José Carlos Ferraz da

doi:10.1590/s0037-86822010000300022

Cited by 41 publications

(43 citation statements)

References 58 publications

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“…Lower rates of prevalence (< 2%) are often reported in North America, Western Europe and Australia (Abbas and Siddiqui, 2011; Bertolini et al , 2012; Fonseca, 2010). This may be influenced by several aspects, including the presence of certain viral genotypes, which are also correlated to the ethnic groups living in a given geographic region (Bertolini et al , 2012; Reis et al , 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Although precise data are scarce on the prevalence of anti-HCV antibodies at population levels, studies based on samples from blood donors showed prevalence rates ranging from 1% in the United Kingdom and New Zealand to 14% in Egypt (Ferreira and Silveira, 2004; Fonseca, 2010; Ortiz et al , 2006). Reports suggest a prevalence of 1% to 2% in Brazil, the same was observed on this study, in which it was observed a seropositivity of 1.4% (Ferreira and Silveira, 2004; Tonial et al , 2011).…”

Section: Discussionmentioning

confidence: 99%

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Seroprevalence of Hepatitis B and C markers at the population level in the municipality of Caxias do Sul, southern Brazil

Menegol¹,

Spilki²

2013

Braz. J. Microbiol.

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Chronic viral hepatitis are main public health problems worldwide. Data about the seroprevalence to Hepatitis B and C viruses (HBV e HCV) at the population level are scarce on Brazil and especially for the Southern region of the country. The seroprevalence to HBV and HBC antigens was evaluated on a large portion of the population of the municipality of Caxias do Sul (427,858 inhabitants), Brazil. A total of 60,604 individual serum samples collected from 2008 to 2011 were screened for HBV surface antigen (HBsAg) and for antibodies against HBsAg; anti HCV antibodies were measured by ELISA (Enzyme Linked Immunosorbent Assay). Overall, 1.63% of the individuals were positive for HBsAg and 1.43% showed seropositivity to HCV. From the total, 31,749 samples were analyzed for HBsAg and 28,855 for HCV. For HBsAg, 519 samples showed positive (1.63%) while the results for 37 patients (0.12%) remained inconclusive. For the anti-HCV test, 412 individuals (1.43%) showed positive. From the positive samples for HBsAg 216 (50.6%) were from male individuals whereas for anti-HCV the seroprevalence was slightly higher for females 216 (52.4%). The higher prevalence for both hepatitis viruses were found among individuals at the age group of 40 to 59 years and the lower levels of positivity for both HBV and HBC were among children and teenagers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Hepatitis B and C markers at the population level in the municipality of Caxias do Sul, southern Brazil

Menegol¹,

Spilki²

2013

Braz. J. Microbiol.

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“…Although epidemics of jaundice, most likely attributed to viral hepatitis, date back thousands of years to ancient China (Fonseca, 2010), the five viruses (named hepatitis A to E viruses) that are responsible for the majority of the world’s cases of acute and chronic hepatitis were discovered only in the past 60 years (Table 1). Combined, they cause a wide spectrum of disease ranging from inapparent to fulminant hepatitis in acute infection and from mild necroinflammatory liver disease to cirrhosis and hepatocellular carcinoma in chronic infection.…”

Section: Introductionmentioning

confidence: 99%

Immune Responses to HCV and Other Hepatitis Viruses

2014

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Summary Five human hepatitis viruses cause most acute and chronic liver disease worldwide. Over the past 25 years hepatitis C virus (HCV) in particular has received much interest because of its ability to persist in most immunocompetent adults and the lack of a protective vaccine. Here we examine innate and adaptive immune responses to HCV infection. Although HCV activates an innate immune response, it employs an elaborate set of mechanisms to evade interferon (IFN)-based antiviral immunity. By comparing innate and adaptive immune responses to HCV with those to hepatitis A and B viruses, we suggest that prolonged innate immune activation impairs the development of successful adaptive immune responses. Comparative immunology furthermore provides insights into the maintenance of immune protection. We conclude by discussing prospects for an HCV vaccine and future research needs for the hepatitis viruses.

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“…(4,8,11) Dating back to the mid-18th century, historical accounts record deaths of members of the French Royal Academy of Science by a disease described acute icteric fever, during an expedition through the Amazon River, in Brazil. (12) During the second half of the 20th century, studies describe a serious icteric condition, of rapid evolution and with death records of five days after the initial symptoms in the city of Lábrea, in the interior of the state of Amazonas. The condition was initially named as Labrea black fever, (13) but the cases were investigated and in 1987 it was confirmed that the Labrea black fever was, in fact, fulminant hepatitis caused by infection of the HDV in patients with HBV.…”

Section: Introductionmentioning

confidence: 99%

Evidências científicas sobre a hepatite Delta no Brasil: revisão integrativa da literatura

et al. 2017

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Objective: Describe the level of scientific evidence on infections by the hepatitis Delta virus (HDV) in Brazil. Methods: Integrative literature review, with research in the databases of the Medical Literature Analysis and Retrieval System Online, Latin American and Caribbean Center on Health Sciences Information, Scientific Eletronic Library Online and Scopus, with analysis focusing on the leveling of the methodological rigor according to the model of Melnyk and Fineout-Overholt. Results: The search revealed an average of two publications a year between 1987 and 2017. We selected 33 articles, the majority (91%) presented level of evidence VI. The publications were concentrated in the area of tropical medicine (46%) and virology (15%). The authors of 85% of the studies were medical professionals and the most common design was the descriptive/cross-sectional (69.6%). Conclusion: Scientific literature on HDV infections in Brazil is focused on prevalence studies, showing incipiency regarding the production of studies with stricter guidelines, such as clinical trials. ResumoObjetivo: Descrever o nível de evidência científica sobre a infecção por vírus da hepatite Delta (VHD) no Brasil. Métodos: Revisão integrativa da literatura, com buscas realizadas nas bases de dados do Medical Literature Analysis and Retrieval System Online, Literatura Latino-americana e do Caribe em Ciências da Saúde, Scientific Eletronic Library Online e Scopus, com análise centrada no nivelamento do rigor metodológico de acordo com o modelo de Melnyk e Fineout-Overholt. Resultados: A busca revelou uma média de duas publicações por ano no intervalo entre 1987 e 2017. Foram selecionados 33 artigos, tendo a maioria (91%) apresentado nível de evidência VI. As publicações ficaram concentradas em periódicos da área de medicina tropical (46%) e virologia (15%). Dos trabalhos, 85% tinha profissional médico com autor e o delineamento mais encontrado foi o descritivo/transversal (69,6%). Conclusão: A produção científica sobre a infecção por VHD no Brasil está centrada em estudos de prevalência, mostrando-se incipiente quanto à produção de estudos com delineamentos mais rígidos como ensaios clínicos.

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Histórico das hepatites virais

Cited by 41 publications

References 58 publications

Seroprevalence of Hepatitis B and C markers at the population level in the municipality of Caxias do Sul, southern Brazil

Seroprevalence of Hepatitis B and C markers at the population level in the municipality of Caxias do Sul, southern Brazil

Immune Responses to HCV and Other Hepatitis Viruses

Evidências científicas sobre a hepatite Delta no Brasil: revisão integrativa da literatura

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